Ethnomedical information and in vitro screening for angiotensin-converting enzyme inhibition of plants utilized as traditional medicines in Gujarat, Rajasthan and Kerala (India)

Nyman, Ulf; Joshi, Pravin Kumar; Madsen, L.B; Pedersen, T.B; Pinstrup, M; Rajasekharan, S.; George, V. Cijo; Pushpangadan, P.

doi:10.1016/s0378-8741(97)00158-x

Cited by 74 publications

(41 citation statements)

References 7 publications

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“…Whole plant Gout, cuts, [24,25] Leaves Hypertension [26] Rajasthan Vanhaakal, Sakad, Budu, Padu Whole plant Paste applied on chest for curing swelling, pulmonary inflammation and intense burning sensation; rheumatism [27][28][29]31] Stem Juice for curing inflammation [30] Mizoram Lenpat Whole plant Wounds [33] West Bengal and North-east region Mandala, Gula, Santali Stem and whole plant…”

Section: Traditional Usesmentioning

confidence: 99%

Viscum articulatum Burm. f.: a review on its phytochemistry, pharmacology and traditional uses

Patel

Singh

2018

Journal of Pharmacy and Pharmacology

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Objectives The aim of this study was to review and highlight traditional and ethnobotanical uses, phytochemical constituents, IP status, biological activity and pharmacological activity of Viscum articulatum. Methods Thorough literature searches were performed on Viscum articulatum, and data were analysed for reported traditional uses, pharmacological activity, phytochemicals present and patents filed. Scientific and patent databases such as PubMed, Science Direct, Google Scholar, Google patents, USPTO and Espacenet were searched using different keywords. Key findings Viscum articulatum has been traditionally used in different parts of the world for treatment of various ailments. Almost all the parts such as leaves, root, stem and bark are having medicinal values and are reported for their uses in Ayurvedic and Chinese system of medicine for the management of various diseases. Modern scientific studies demonstrate efficacy of this plant against hypertension, ulcer, epilepsy, inflammation, wound, nephrotoxicity, HIV, cancer, etc. Major bioactive phytochemicals include oleanolic acid, betulinic acid, eriodictyol, naringenin, b-amyrin acetate, visartisides, etc. Conclusions Side effects of allopathic medicines have created a global opportunity, acceptance and demand for phytomedicines. Viscum articulatum could be an excellent source of effective and safe phytomedicine for various ailments if focused translational efforts are undertaken by integrating the existing outcomes of researches.

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Section: Traditional Usesmentioning

confidence: 99%

Viscum articulatum Burm. f.: a review on its phytochemistry, pharmacology and traditional uses

Patel

Singh

2018

Journal of Pharmacy and Pharmacology

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“…A number of screening studies on plants (Anderson and Anderson, 1997;Nyman et al, 1998;Duncan et al, 1999;Oh et al, 2002) and a natural class of compounds such as alkaloids (Oh et al, 2003), xanthones (Chen and Lin, 1992), terpenoids (Morigiwa et al, 1986;Hansen et al, 1996), fatty acids (Morota et al, 1987), peptides , hydrolysable tannins (Ueno et al, 1988), proanthocyanidins , flavonoids (Kameda et al, 1987;Actis-Goretta et al, 2003;Oh et al, 2004) have been reported to exert ACE inhibition activity.…”

mentioning

confidence: 99%

Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae)

Loizzo

Said

Tundis

et al. 2006

Phytotherapy Research

172

115

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“…The presence of total polyphenols, including tannins, on the extracts might be related to this not specific in vitro inhibition. Nyman et al (1998), observed that only four species, from the thirteen considered active in the ACE assay, remained presenting dose-dependent inhibitory ACE activity after tannins were removed. Polyphenols, distinctly from flavonoids, might be related to the inhibitory ACE activity of B. capillaris species.…”

Section: Resultsmentioning

confidence: 99%

In vivo hypotensive effect and in vitro inhibitory activity of some Cyperaceae species

Martins

Pacheco

Perini

et al. 2013

Braz. J. Pharm. Sci.

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In 1820, French naturalist August Saint Hillaire, during a visit in Espírito Santo (ES), a state in southeastern Brazil, reported a popular use of Cyperaceae species as antidote to snake bites. The plant may even have a hypotensive effect, though it was never properly researched. The in vitro inhibitory of the angiotensin converting enzyme (ACE) activity of eigth ethanolic extracts of Cyperaceae was evaluated by colorimetric assay. Total phenolic and flavonoids were determined using colorimetric assay. The hypotensive effect of the active specie (Rhychonospora exaltata, ERE) and the in vivo ACE assay was measured in vivo using male Wistar Kyoto (ERE, 0.01-100mg/kg), with acetylcholine (ACh) as positive control (5 µg/kg, i.v.). The evaluation of ACE in vivo inhibitory effect was performed comparing the mean arterial pressure before and after ERE (10 mg/kg) in animals which received injection of angiotensin I (ANG I; 0,03, 03 and 300 µg/kg, i.v.). Captopril (30 mg/kg) was used as positive control. Bulbostylis capillaris (86.89 ± 15.20%) and ERE (74.89 ± 11.95%, ERE) were considered active in the in vitro ACE inhibition assay, at 100 µg/mL concentration. ACh lead to a hypotensive effect before and after ERE's curve (-40±5% and -41±3%). ERE showed a dose-dependent hypotensive effect and a in vivo ACE inhibitory effect. Cyperaceae species showed an inhibitory activity of ACE, in vitro, as well as high content of total phenolic and flavonoids. ERE exhibited an inhibitory effect on both in vitro and in vivo ACE. The selection of species used in popular medicine as antidotes, along with the in vitro assay of ACE inhibition, might be a biomonitoring method for the screening of new medicinal plants with hypotensive properties.Uniterms: Cyperaceae/species/pharmacognosy. Cyperaceae/species/in vitro inhibitory activity. Cyperaceae/species/in vivo hypotensive effect. Angiotensin converting enzyme/in vitro inhibitory. Flavonoids/determination. Em 1820, o naturalista francês August Saint Hillaire, durante uma visita ao Espírito Santo (ES), Estado do sudeste do Brasil, relatou o uso popular de espécies de Cyperaceae como antídoto para picadas de cobra. As espécies podem possuir efeito hipotensor, embora nunca tenham sido devidamente pesquisadas. A inibição in vitro da atividade da enzima conversora da angiotensina (ECA) de oito extratos etanólicos de Cyperaceae foi avaliada por ensaio colorimétrico. Totais de fenólicos e flavonóides foram determinados utilizando ensaio colorimétrico. O efeito hipotensor da espécie ativa (Rhychonospora exaltata, ERE) no ensaio de ECA in vitro foi avaliada in vivo utilizando-se machos Wistar Kyoto (ERE, 0.01-100 mg/kg), com a acetilcolina (ACh), como controle positivo (5 µg/kg, iv). A avaliação do efeito inibidor da ECA in vivo foi realizado comparando-se a pressão arterial média, antes e após ERE (10 mg/kg) nos animais que receberam injeção de angiotensina I (Ang I, 0,03, 03 e 300 µg/kg, iv). Captopril (30 mg/kg) foi utilizado como controle positivo. Bulbostylis capillaris (86,89±15,20%) e ERE (7...

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Ethnomedical information and in vitro screening for angiotensin-converting enzyme inhibition of plants utilized as traditional medicines in Gujarat, Rajasthan and Kerala (India)

Cited by 74 publications

References 7 publications

Viscum articulatum Burm. f.: a review on its phytochemistry, pharmacology and traditional uses

Viscum articulatum Burm. f.: a review on its phytochemistry, pharmacology and traditional uses

Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae)

In vivo hypotensive effect and in vitro inhibitory activity of some Cyperaceae species

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