BJP
IntroductionAndaman and Nicobar Islands, a union territory of India, has been historically known for high malaria transmission. The tropical climate prevailing throughout the year provides an ideal environment for mosquito proliferation and breeding in Nicobar group of islands (Manimunda et al., 2011). Entire land mass in the island has a network of creeks which results in ideal brackish water habitats for the breeding of Anopheles sundaicus, the predominant vector of malaria in Andaman and Nicobar Islands (Krishnamoorthy et al., 2005).Malaria prevalence has increased alarmingly in past few years due to the development of drug resistance by Plasmodium falciparum (Parzy et al., 1997). Therefore, new and more effective therapeutic agents are urgently required to overcome the problem of malaria.The Karen tribe is a lesser-known community in these Islands, settled in Mayabunder, North and Middle Andaman District. Karen derives from the word 'Kavin'as British called them, while they called themselves as Pwakanyaw, the quiet and easy going people, hailing from Henzada, Pathe and Nachaon areas of Pegu district in Western Myanmar (Oberai, 2000). Presently they inhabit three villages depending on agriculture and fishing for livelihood. Most of them depend on traditional medicine, though modern medicine had increased rapidly during recent times (Chander et al., 2015). As a part of the ongoing studies documented their traditional treatment practices and collected plants which were reported to be efficacious in the treatment of traditional medicine system.In the present study, nine of these plants were subjected to in vitro antimalarial activity against P. falciparum chloroquine-sensitive (MRC-2) isolate.
Materials and Methods
Plant materialsNine plants were selected for evaluation on the basis of their ethnomedicinal histories. The names of these
AbstractThe aim of this study was to assess the antimalarial activity of nine medicinal plants used by Karens of Andaman and Nicobar Islands, against Plasmodium falciparum chloroquine-sensitive MRC-2 isolate. The methanol extracts were obtained by cold percolation method and in vitro antimalarial activity was assessed using M-III method. The results indicated that out of nine plant species tested, four plants, viz., Z. spectabilis, S. wallichiana, C. pulcherrima and Amomum sp. demonstrated significant antimalarial activity (50% inhibitory concentration values were 5.5 ± 0.7, 12.0 ± 2.5, 14.6 ± 1.3 and 37.3 ± 2.5 μg/mL respectively) with no toxicity effect on erythrocytes.Article Info