Ethnomedicinal knowledge, belief and self-reported practice of local inhabitants on traditional antimalarial plants and phytotherapy

Karunamoorthi, Kaliyaperumal; Tsehaye, Endrias

doi:10.1016/j.jep.2012.02.012

Cited by 52 publications

(41 citation statements)

References 20 publications

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“…Plants are the major resource for the treatment of malaria infections in sub-Saharan Africa, where health care facilities are limited [77]. Ethnomedicinal plants have played a pivotal role in the treatment of malarial for centuries [78,79].…”

Section: Ethnologic Antimalarial Compoundsmentioning

confidence: 99%

Antimalarial Activity of Plant Metabolites

Pan¹,

Xu²,

Shi³

et al. 2018

Preprint

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Malaria, as a major global health problem, continues to affect a large number of people each year, especially those in the developing countries. Effective drug discovery is still one of the main efforts to control malaria. As natural products are still considered as a key source for discovery and development of therapeutic agents, we have evaluated more than 2,000 plant extracts against Plasmodium falciparum. As a result, we discovered dozens of plant leads that displayed antimalarial activity. Our phytochemical study of some of these plant extracts led to identification of several potent antimalarial compounds. The prior comprehensive review article entitled "Antimalarial activity of plant metabolites" by Schwikkard and Van Heerden (2002) reported structures of plant-derived compounds with antiplasmodial activity and covered literature up to the year 2000. As a continuation of this effort, the present review covers the antimalarial compounds isolated from plants, including marine plants, reported in the literatures from 2001 to the end of 2017. During the span of the last 17 years, 175 antiplasmodial compounds were discovered from plants. These active compounds are organized in our review article according to their plant families. In addition, we also include ethnobotanical information of the antimalarial plants discussed.

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Section: Ethnologic Antimalarial Compoundsmentioning

confidence: 99%

Antimalarial Activity of Plant Metabolites

Pan¹,

Xu²,

Shi³

et al. 2018

Preprint

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“…9 The plant showed iron chelating activity revealing it may act by reducing the accumulation of iron during the treatment. B. abyssinica is traditionally used for the treatment of malaria, 21 cancer, ulcer, rheumatism, wounds 22 and diabetes. 23 Free radicals are involved in the genesis of most of these diseases.…”

Section: Discussionmentioning

confidence: 99%

Iron Reducing and Radical Scavenging Activities of 13 Medicinal Plants From Côte d’Ivoire

Ehouman¹,

Witabouna²,

Bakayoko³

et al. 2015

Phcog J

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Objective: Oxidative stress has been involved in the development of varied human diseases. The aim of this study was to evaluate the iron reducing power and the antiradical activity of 13 plants traditionally used as medicinal plants in Côte d'Ivoire. Materials and Methods: FRAP (ferric reducing antioxidant power) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) assays were used to assess the antioxidant property of 80% methanol extracts prepared from the 13 plants. Results: A high iron reducing activity was exhibited by extracts from leaves of Leea guineensis (42.76 ± 28.54 mg of TE/gdry extract) and Bersama abyssinica (39.77 ± 31.29 mg of TE/g dry extract). Smeathmannia pubescens (% ABTS = 92.44 ± 12.93%), L. guineensis (%ABTS = 89.73 ± 15.10%), Keetia venosa (% ABTS = 88.78 ± 17.36 %) and Sapium ellipticum (%ABTS = 85.86 ± 25.10%), showed promising antiradical activity with IC 50 values of 4.50, 5.00, 5.40 and 5.70 µg/mL respectively. These values are (p < 0.05) close to those of Trolox (CI 50 = 4.10 µg/mL) and ascorbic acid (CI 50 = 4.90 µg/mL). Conclusion: Our findings confirm the traditional use of the studied plants in treatment of various ailments. The results obtained provide promising baseline information for using these medicinal plants for improving the health status of the population.

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“…Since malaria is a major public health issue in the resource-limited settings, where there is a fragile health care system, it quite often fails to meet the expectation of needy poor people. The existing potent antimalarial ACTs has been often unaffordable, inaccessible and the recent reports indicate the emergence of multi-drug resistance strains against ACTs too (Karunamoorthi and Tsehaye, et al, 2012). As a result, in order to address the antimalarial drug resistance catastrophe, a keen interest has been observed among the researches towards TSM to explore the possibilities of identifying the new affordable, accessible and potential antimalarial drugs from our age-old TSM.…”

Section: Antiplasmodial Activitymentioning

confidence: 99%

“…Moreover, Ngemenya et al (2004) has also recorded the antiplasmodial activity of the leaves and seeds of C. papaya with IC 50 of about 60 µg/ml. In Ethiopia, Karunamoorthi and Tsehaye (2012) reported that the local residents are consuming the powder of the papaya seeds by mixing with honey orally as an antimalarial agent. A study was carried out evaluate the antimalarial activity of the methanolic seed extract of C. papaya on Plasmodium berghei infected mice.…”

Section: Antiplasmodial Activitymentioning

confidence: 99%

“…However, so far there is no comprehensive report on the phyto-chemistry and mode of action of papaya with reference to its antiplasmodial activity. Therefore, further pharmacological and phytochemical investigations on papaya are required to be warranted to authenticate the claims or beliefs on the efficacy and safety concerns (Karunamoorthi and Tsehaye et al, 2012).…”

Section: Antiplasmodial Activitymentioning

confidence: 99%

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Papaya: A gifted nutraceutical plant - a critical review of recent human health research

Karunamoorthi¹,

Kim²,

Jegajeevanram³

et al. 2014

TANG [HUMANITAS MEDICINE]

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The plant kingdom is considered to be a repository of modern medicine, attributable to their rich source of bio-active molecules and secondary metabolites. It is indeed the Nutraceuticals that enhance immunity and ensure a healthier life because of their prophylactic and therapeutic values. Over centuries, papaya [Caricaceae; (Carica papaya Linn.)] is a renowned nutritious and medicinal plant. Each part of the papaya like root, stem, leaf, flower, fruit, seed, rinds, and latex has its own nutraceutical properties. It serves as food, cooking aid, and Ethnomedicine to prevent and treat wide-range of diseases and disorders. It has also been traditionally used as appetite enhancer, meat tenderizer, purgative, medicinal acne, abortifacient and vermifuge. Over decades, a series of scientific attempts were made to authenticate the nutraceutical properties of papaya. These studies validated that the papaya has antiplasmodial, antitrichochramal, antitrichomonal, antidengue, and anti-cancer activities. They have also exhibited that papaya possesses antiseptic, antiparasitic, anti-inflammatory, antidiabetic, and contraceptive features, and it helps in the management of sickle-cell anaemia, HIV, heart diseases and digestional disorders too. Nevertheless, the responsible bio-active molecules and their mode of actions remain indistinct and imprecise, and this calls for further pharmacological and clinical research on them. Conclusively, papaya is one of the naturally gifted plants; though its nutraceutical properties as a food or as a quasi-drug are poorly understood or undervalued by people. Accordingly, this scrutiny, demand for instigation of public health awareness campaigns to promote papaya consumption, so that the society shall acquire optimal benefits of papaya and in turn prevent and alleviate various diseases and illness.

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Ethnomedicinal knowledge, belief and self-reported practice of local inhabitants on traditional antimalarial plants and phytotherapy

Cited by 52 publications

References 20 publications

Antimalarial Activity of Plant Metabolites

Antimalarial Activity of Plant Metabolites

Iron Reducing and Radical Scavenging Activities of 13 Medicinal Plants From Côte d’Ivoire

Papaya: A gifted nutraceutical plant - a critical review of recent human health research

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