Ethnomedicinal, phytochemical and pharmacological profile of a mangrove plant Ceriops Decandra GriffDin Hou.

Mahmud, Imran; Shahria, Naznin; Yeasmin, Sabina; Iqbal, Asif; Mukul, Emdadul Hasan; Gain, Sudipta; Shilpi, Jamil A.; Islam, Md. Khirul

doi:10.1515/jcim-2017-0129

Cited by 15 publications

(10 citation statements)

References 96 publications

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“…Ceriops decandra, a mangrove plant, exhibits diverse therapeutic activities as supported by its traditional medicinal uses and phytochemical studies. Different plant parts are utilized for treating diarrhea, dysentery, skin diseases, ulcers, rheumatism, and inflammatory conditions [ 16 , 17 ]. Extracts and isolated compounds from C. decandra have demonstrated antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activities [ 17 , 18 ], validating its ethnomedicinal applications.…”

Section: Resultsmentioning

confidence: 99%

Molecular docking analysis of marine compounds with voltage gated calcium channel for potential anti-epileptic molecules

Sheokand,

Grewal,

Kumar

et al. 2024

Bioinformation

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Epileptic seizures are directly linked with an anomalous influx of extracellular calcium or sodium anions through voltage-gated channels disturb the chemical and electrical gradients, resulting in seizures or jerking moments. Voltage-gated calcium channel (VGCC) subunit α2δ-1 is the binding site for gabapentinoids used to treat epilepsy and neuropathic pain. However, this class of drugs showed severe side effects associated with CNS and respiratory depression. Hence, we screened a total of 2583 phytochemicals from the Comprehensive Marine Natural Products Database for their drug likeliness and pharmacokinetics (ADME/T) properties. The selected phytochemicals were docked with the VGCC α2δ-1 protein target and the marketed AED Pregabalin is used as standard. The docking results helped to select 45 docked compounds with better binding affinity, among which Acanthiline A showed the maximum binding affinity with the binding energy of -11.9 kcal/mol, thus reflecting its potential anti-epileptic activity.

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Section: Resultsmentioning

confidence: 99%

Molecular docking analysis of marine compounds with voltage gated calcium channel for potential anti-epileptic molecules

Sheokand,

Grewal,

Kumar

et al. 2024

Bioinformation

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“…PGPR supplementation under salt stress increased the accumulation of secondary metabolites but decreased glucosinolate content. Brassica is rich in various bioactive phytochemicals such as glucosinolates and phenolic compounds, including phenols, flavonoids, and carotenoids [ 124 , 125 , 126 ]. These phenolic compounds have a crucial role in absorbing and neutralizing free radicals, quenching singlet oxygen, and detoxifying peroxides [ 59 , 127 ].…”

Section: Discussionmentioning

confidence: 99%

Palliating Salt Stress in Mustard through Plant-Growth-Promoting Rhizobacteria: Regulation of Secondary Metabolites, Osmolytes, Antioxidative Enzymes and Stress Ethylene

Khan

Umar

Iqbal

2023

Plants

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The severity of salt stress is alarming for crop growth and production and it threatens food security. Strategies employed for the reduction in stress are not always eco-friendly or sustainable. Plant-growth-promoting rhizobacteria (PGPR) could provide an alternative sustainable stress reduction strategy owning to its role in various metabolic processes. In this study, we have used two strains of PGPR, Pseudomonas fluorescens (NAIMCC-B-00340) and Azotobacter chroococcum Beijerinck 1901 (MCC 2351), either singly or in combination, and studied their effect in the amelioration of salt toxicity in mustard cultivar Pusa Jagannath via its influence on plants’ antioxidants’ metabolism, photosynthesis and growth. Individually, the impact of Pseudomonas fluorescens was better in reducing stress ethylene, oxidative stress, photosynthesis and growth but maximal alleviation was observed with their combined application. MDA and H2O2 content as indicator of oxidative stress decreased by 27.86% and 45.18% and osmolytes content (proline and glycine-betaine) increased by 38.8% and 26.3%, respectively, while antioxidative enzymes (SOD, CAT, APX and GR) increased by 58.40, 25.65, 81.081 and 55.914%, respectively, over salt-treated plants through the application of Pseudomonas fluorescens. The combined application maximally resulted in more cell viability and less damage to the leaf with lesser superoxide generation due to higher antioxidative enzymes and reduced glutathione formation (GSH). Considering the obtained results, we can supplement the PGPR in combination to plants subjected to salt stress, prevent photosynthetic and growth reduction, and increase the yield of plants.

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“…Most of the compounds have been isolated from the aerial parts, with coumarins and alkaloids being the main compounds. The other plant parts such as roots, stembarks, and fruits deserve to be explored (47,48). In fact, the phytochemical composition of RM plant varies depending on different factors, especially the development stage, harvest season, extraction solvent, plant's part used, plant's origin, storage conditions, and analytical method used (38).…”

Section: Crude Extractsmentioning

confidence: 99%

Ruta montana(L.) L.: An insight into its medicinal value, phytochemistry, biological properties, and toxicity

Benkhaira¹,

Koraichi²,

Fikri-Benbrahim³

2022

J Herbmed Pharmacol

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Ruta montana (RM) is a medicinal and aromatic plant (MAP) used in folk medicine, especially in North Africa, to treat digestive, infectious, respiratory, neurological, gynecological, and diabetic diseases. The current work aims to review the scientifically validated ethno-medicinal usage, bioactivities and phytochemistry of RM, in order to provide data support for further investigations. Data were procured from PubMed, Scopus, Google Scholar, Web of Science, ScienceDirect, and PubChem. The present study revealed that RM could be used to manage many diseases involved in public health problems, such as diabetes, hypertension, neurological disorders, infections, reproductive system disorders, and cancer. It might also replace chemical insecticides and fungicides since it exhibits antifungal, insecticidal, and larvicidal properties. RM extracts also contain mainly coumarins and alkaloids. The volatile oil of RM is characterized by an abundance of ketone compounds and 2-undecanone as major constituents. In the case of a high-dose administration, RM infusion can cause poisoning through the oral path. Thus, in-depth in vivo pharmacological studies and clinical trials are needed to transmute the traditional applications of RM into scientific-based information.

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Ethnomedicinal, phytochemical and pharmacological profile of a mangrove plant Ceriops Decandra GriffDin Hou.

Cited by 15 publications

References 96 publications

Molecular docking analysis of marine compounds with voltage gated calcium channel for potential anti-epileptic molecules

Molecular docking analysis of marine compounds with voltage gated calcium channel for potential anti-epileptic molecules

Palliating Salt Stress in Mustard through Plant-Growth-Promoting Rhizobacteria: Regulation of Secondary Metabolites, Osmolytes, Antioxidative Enzymes and Stress Ethylene

Ruta montana(L.) L.: An insight into its medicinal value, phytochemistry, biological properties, and toxicity

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