This study was aimed at evaluating the effect of Uvaria chamae extract in protecting against Naja nigricollis envenomations. Uvaria chamae is a well-known medicinal plant in Nigeria traditional medicine for the management of snakebite. Freshly collected Uvaria chamae leaves and stems were air-dried, powdered and extracted in methanol. The median lethal dose of the extract was determined and further fractionated with n-hexane, n-butanol and ethyl acetate. Each fraction was tested for neutralizing effect against venom-induced haemolytic, fibrinolytic, hemorrhagic, and cytotoxic activities. The result obtained showed significant (p<0.05) antihaemolytic activity of Uvaria chamae in n-butanol 31.40%, aqueous residue 39.60% and ethyl acetate 40.70% fractions when compared to positive controls, but in n-hexane, the activity 33% was not significantly (p>0.05) increased. Antifibrinolytic activity was significantly (p<0.05) increase in n-hexane 73.88%, n-butanol 72.22% and aqueous residue 72.22% fractions. Antihaemorrhagic significant (p<0.05) increase in all the concentrations of each fraction except for n-butanol and aqueous residues at 400 mg/kg; antihaemorrhagic effect was more at 100 and 200 mg/mL concentration following experimental envenomation. Uvaria chamae fractions were found to possess a high level of protection against Naja nigricollis venoms-induced lethality, compared to positive controls. The results apparently provide the pharmacological rationale for the use of the leaves of Uvaria chamae in the management of snakebite envenomation.