Ethnomedicinal Plants Used for the Treatment of Cardiovascular Diseases by Healers in the Southwestern State of Paraná, Brazil, and Their Validation Based on Scientific Pharmacological Data

Menetrier, Jacqueline Vergutz; Bonkoski, Viviane Risso; Medeiros, Kamila Aparecida; Estevan, Daniela Aparecida; Palozi, Rhanany Alan Calloi; Lívero, Francislaine Aparecida dos Reis; Velasquez, Leonardo Garcia; Lourenço, Emerson Luiz Botelho; Gasparotto, Arquimedes

doi:10.1007/s10943-019-00960-1

Cited by 8 publications

(5 citation statements)

References 102 publications

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“…The use of B. roxburghii against diabetes and blood purification among the Adi, Nocte and Nyishi (Tangjang et al 2011), E. officinalis against diabetes and heart disease by the Apatani (Khongsai et al 2015) and M. charantia against diabetes and blood pressure among the Galo, Monpa, Nyishi and Tagin tribes (Murtem & Chaudhry 2016 were found. The use report of Centella asiatica, M. charantia, and Clerodendrum glandulosum in the treatment of cardiovascular ailments have also been found in other parts of the world (Maruthupandian et al 2011, Menetrier et al 2020, Sharma et al 2001, Uddin et al 2019.…”

Section: Cardiovascular Disordersmentioning

confidence: 89%

Ethnomedicinal plants used by the indigenous tribal communities of Arunachal Pradesh, India: a review

Bushi

Bam

Mahato

et al. 2021

Ethnobot. Res. App.

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Section: Cardiovascular Disordersmentioning

confidence: 89%

Ethnomedicinal plants used by the indigenous tribal communities of Arunachal Pradesh, India: a review

Bushi

Bam

Mahato

et al. 2021

Ethnobot. Res. App.

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“…One of the most studied folk medicinal Cuphea species is C. carthagenensis , known as Colombian waxweed. Whole plants or aerial parts are commonly used as antihypertensives [ 76 , 103 , 111 ]. The species is also an antinociceptive, antiviral, antimicrobial, anti-inflammatory, and weight-reducing agent [ 112 ].…”

Section: Pharmacological Activity Of Cuphea Plants...mentioning

confidence: 99%

The Genus Cuphea P. Browne as a Source of Biologically Active Phytochemicals for Pharmaceutical Application and Beyond—A Review

Sobolewska

Michalska

Wróbel‐Biedrawa

et al. 2023

IJMS

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Cuphea P. Browne (Lythraceae) is a monophyletic taxon comprising some 240–260 species that grow wild in the warm, temperate, and tropical regions of South and Central America and the southern part of North America. They have been valued as traditional medicinal remedies for numerous indications, including treating wounds, parasitic infections, hypertension, digestive disorders, cough, rheumatism, and pain. Modern pharmacological research provides data that support many of these traditional uses. Such a wide array of medicinal applications may be due to the exceptionally rich phytochemical profile of these plants, which includes bioactive compounds classified into various metabolite groups, such as polyphenols, triterpenes, alkaloids, and coumarins. Furthermore, Cuphea seed oils, containing medium-chain fatty acids, are of increasing interest in various industries as potential substitutes for coconut and palm oils. This review aims to summarize the results of phytochemical and pharmacological studies on Cuphea plants, with a particular focus on the therapeutic potential and molecular mechanisms of the action of polyphenolic compounds (especially flavonoids and tannins), which have been the subject of many recently published articles.

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“…Tis tropical plant is a valuable resource in traditional medicine due to its numerous therapeutic benefts. Its leaves are traditionally used for dietary supplementation (due to their rich protein content) and for their antioxidant, antitumor, anti-infammatory, lipid-lowering, antidiabetic, and hypotensive efects [18][19][20][21][22]. However, pharmacological research into its efectiveness in treating liver disorders remains lacking.…”

Section: Introductionmentioning

confidence: 99%

Bridging the Gap: Exploring the Preclinical Potential of Pereskia grandifolia in Metabolic‐Associated Fatty Liver Disease

Rodrigues Albuquerque,

Ratti da Silva,

de Abreu Braga

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Metabolic-associated fatty liver disease (MAFLD) is a complex condition characterized by steatosis and metabolic disturbances. Risk factors such as diabetes, cigarette smoking, and dyslipidaemia contribute to its development and progression. Effective and safe therapies for MAFLD are urgently needed. Pereskia grandifolia has shown potential as an alternative treatment, but its effectiveness against liver disease remains unexplored. This research aims to determine the hepatoprotective properties of P. grandifolia using a model of MAFLD. The study was carried out through various phases to assess the safety and efficacy of the ethanol-soluble fraction of P. grandifolia. Initially, an in vitro assay was performed to assess cell viability. This was followed by an acute toxicity test conducted in rats to determine the safety profile of the extract. Subsequently, the anti-inflammatory properties of P. grandifolia were examined in macrophages. For the MAFLD study, diabetic Wistar rats were made diabetic and exposed to a high fat diet and cigarette smoke, for 4 weeks. During the last 2 weeks, the rats were orally given either the vehicle (negative control group; C-), P. grandifolia (30, 100, and 300 mg/kg), or insulin in addition to simvastatin. A basal group of rats not exposed to these risk factors was also assessed. Blood samples were collected to measure cholesterol, triglycerides, glucose, ALT, and AST levels. Liver was assessed for lipid and oxidative markers, and liver histopathology was examined. P. grandifolia showed no signs of toxicity. It demonstrated anti-inflammatory effects by inhibiting phagocytosis and macrophage spreading. The MAFLD model induced liver abnormalities, including increased AST, ALT, disrupted lipid profile, oxidative stress, and significant hepatic damage. However, P. grandifolia effectively reversed these changes, highlighting its potential as a therapeutic agent. These findings emphasize the significance of P. grandifolia in mitigating hepatic consequences associated with various risk factors.

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Ethnomedicinal Plants Used for the Treatment of Cardiovascular Diseases by Healers in the Southwestern State of Paraná, Brazil, and Their Validation Based on Scientific Pharmacological Data

Cited by 8 publications

References 102 publications

Ethnomedicinal plants used by the indigenous tribal communities of Arunachal Pradesh, India: a review

Ethnomedicinal plants used by the indigenous tribal communities of Arunachal Pradesh, India: a review

The Genus Cuphea P. Browne as a Source of Biologically Active Phytochemicals for Pharmaceutical Application and Beyond—A Review

Bridging the Gap: Exploring the Preclinical Potential of Pereskia grandifolia in Metabolic‐Associated Fatty Liver Disease

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