Ethnomedicinal use and phytochemical analysis of medicinal plants used to treat gastrointestinal conditions by Awambo people in Iikokola Village, Namibia

Shatri, Albertina Mn; Mumbengegwi, Davis R.

doi:10.1016/j.sciaf.2022.e01428

Cited by 7 publications

(9 citation statements)

References 19 publications

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“…Medicinal plants contain various bioactive compounds which have therapeutic properties and can be used for treating common ailments like colds, coughs, digestive disorders, skin conditions, and pain relief, [22] while other medicinal plants have shown potential in managing chronic diseases such as diabetes, cardiovascular disorders, and cancer. [23,24] Due to their fewer side effects and ability to effectively eradicate diseases at the root level, medicinal plants are in exponentially greater demand worldwide.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India

Anbhule

Moyo

Jagadhane

et al. 2023

Chemistry & Biodiversity

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The present study shows the chemical profile, antimicrobial, antiproliferative, and apoptotic effects of Stemodia viscosa extracts. Thirteen bioactive compounds were identified in the 80 % ethanolic extract by GC/MS analysis. The acetone extract exhibited a higher content of flavonoids and phenols of 805.10 μg QE/mg DW and 89.31 μg GAE/mg DW extracts, respectively. Furthermore, the acetone extract possessed the highest antioxidant activity (IC50=9.96 μg/mL). The 80 % ethanolic extract exhibited significant antimicrobial activity; the highest activity was observed against Staphylococcus aureus with a zone of inhibition of 25±0.51 mm, MIC value of 4 mg/mL, and MBC value of 8 mg/mL. The antiproliferative results revealed the presence of anticancer activity with an IC50=91.562 and 74.362 μg/mL against the B16F10 skin and COLO205 colon cancer cells, respectively. The flow cytometric analysis shows that the plant extracts cause cancer cell death through the induction of apoptosis. Our findings confirmed that Stemodia viscosa is a potential source of biologically active compounds.

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Section: Resultsmentioning

confidence: 99%

Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India

Anbhule

Moyo

Jagadhane

et al. 2023

Chemistry & Biodiversity

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“…In order to analyze the biological potential of any plant species, the preparation of different extracts from the plant is essential. According to previous research, organic extracts prepared employing methanol, ethanol, and ethyl acetate have more significant concentrations of phytochemical components with strong antibacterial and antidiarrheal activities in vitro and in vivo . Following that, spectrometric and chromatographic screening of the extracts from medicinal plants offers fundamental details of their biochemical and pharmacological activity.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening, In Silico Molecular Docking, ADME Properties, and In Vitro Antioxidant, Anticancer, and Antidiabetic Activity of Marine Halophyte Suaeda maritima (L.) Dumort

Manojkumar,

Thandeeswaran,

Thangavel

et al. 2024

ACS Omega

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Medicinally valuable components derived from natural resources are highly desirable as prospective alternatives to synthetic drugs to treat fatal diseases, such as cancer and diabetes mellitus. Suaeda maritima (L.) Dumort (Amaranthaceae) (S. maritima) is a halophyte plant that can thrive in saline environments and possesses excellent medicinal properties. Hence, for the present investigation, S. maritima has been chosen, and its phytochemical constituents have been extracted utilizing various solvents, including hexane, acetone, and methanol, and identified by GC-MS, LC-MS, and HPLC analyses. The antioxidant activity of the compounds using DPPH, ABTS, and reducing power assays demonstrated that all three extracts of S. maritima possessed significant radical scavenging activity comparable to standard ascorbic acid with lower IC50 values (69.20–95.58 μg/mL). In addition, the evaluation of antidiabetic activity by α-amylase inhibition and α-glucosidase inhibition methods revealed that the acetone extract of S. maritima (SMAE) displayed equipotent activity of standard acarbose with an IC50 of 32.6 μg/mL. Advantageously, SMAE also exhibited better inhibition activity against the growth of lung cancer cells with an IC50 of 78.19. μg/mL and less toxicity on the noncancerous HUVEC cells with a high IC50 of 300 μg/mL. In addition, the cancer cell death mechanism via the apoptotic pathway induced by SMAE was confirmed by DAPI staining and ROS analysis. The analysis of ADME properties, including absorption, distribution, metabolism, and excretion, witnessed that the physicochemical and druglikeness factors were best catered by stigmasterol, γ-sitosterol, and vitamin E. Further, the key phytochemicals identified from SMAE were docked with CtBP1 and SOX2 bound to importin-α target proteins associated with carcinogenic pathways using Schrodinger software. The results showed that the phytochemicals, scilicet, stigmasterol, γ-sitosterol, octadecadienoic acid, and vitamin E, showed a good binding affinity with Glide scores in the range −2.845–4.018 kcal/mol. Overall, the findings support that the least investigated traditional edible medicinal mangrove-related S. maritima is high in pharmacologically active constituents and might be one of the finest sources of naturally derived molecules for drug development and delivery systems.

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“…Corchorus tridens L., also known as Thelele in Sepedi (South Africa), is a wild edible plant species [ 6 , 7 ] widely distributed in 29 African countries, [ 8 ] including Zimbabwe [ 9 ], Senegal [ 10 ] and South Africa [ 11 ], where the leaves are consumed as vegetables. This leafy vegetable has several uses in ethnomedicine, including being used as feed for livestock [ 12 , 13 ], and for treating sexually transmitted infections [ 14 ], diarrhoea and stomach complaints [ 15 ], back pain [ 16 ], fever [ 17 ], and inflammation [ 8 ]. Although limited, the documented in vitro pharmacological evaluation studies of this plant have revealed several biological activities, including anti-oxidant [ 18 ], anti-microbial [ 19 , 20 ], and pesticidal properties [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…The genus is reported to contain approximately 100 species, which are widely distributed in tropical and subtropical regions, with some being the source of fibre for jute production [ 25 ]. Most of the species are consumed as vegetables; however, roughly half of the species are found in Africa [ 15 , 16 , 17 ], mostly in the eastern to southern parts of the continent [ 26 ], with most species occurring in South Africa [ 8 ]. Cultivated species include Corchorus olitorius L. [ 27 ], Corchorus capsularis [ 24 ], and Corchorus incifolious [ 28 ], with C. olitorius and C. capsularis being widely used for commercial purposes [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Corchorus tridens L.: A Review of Its Botany, Phytochemistry, Nutritional Content and Pharmacological Properties

Kudumela,

Ramadwa,

Mametja

et al. 2024

Plants

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Phytotherapy is a cost-effective alternative that continues to evolve. This has sparked significant research interest in naturally occurring compounds found in edible plants that possess antibacterial, antioxidant, and anticancer properties. Corchorus tridens L. is a wild edible plant widely recognised for its edible leaves, which are used for vegetable and animal feed. The plant is widely distributed across the African continent and is utilised in numerous countries for treating fever, pain, inflammation, and sexually transmitted diseases. Extracts from various parts of this plant exhibit antimicrobial, antioxidant, and pesticidal properties. This plant is a rich source of amino acids, vitamins, essential fatty acids, proteins, and minerals, as well as secondary metabolites such as alkaloids, flavonoids, quinines, steroids, terpenoids, phenols, and tannins. Additional studies are still needed to determine other biological activities, such as anti-inflammatory activity, involvement in the treatment of measles, prevention of anaemia, and pain-relieving properties. The current review aims to provide information on the characteristics, distribution, nutritional content, bioactive compounds, traditional uses, and biological activities of the edible plant species C. tridens L. to stimulate further research interest to address the existing literature gaps concerning this plant.

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Ethnomedicinal use and phytochemical analysis of medicinal plants used to treat gastrointestinal conditions by Awambo people in Iikokola Village, Namibia

Cited by 7 publications

References 19 publications

Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India

Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India

Phytochemical Screening, In Silico Molecular Docking, ADME Properties, and In Vitro Antioxidant, Anticancer, and Antidiabetic Activity of Marine Halophyte Suaeda maritima (L.) Dumort

Corchorus tridens L.: A Review of Its Botany, Phytochemistry, Nutritional Content and Pharmacological Properties

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