Ethnomedicinal use, phytochemistry, pharmacology, and toxicology of Daphne gnidium: A review

Khouchlaa, Aya; Menyiy, Naoual El; Guaouguaou, Fatima-Ezzahrae; Baaboua, Aicha El; Charfi, Saoulajan; Lakhdar, Fatima; Omari, Nasreddine El; Taha, Douae; Shariati, Mohammad Ali; Rebezov, Мaksim; El-Shazly, Mohamed; Bouyahya, Abdelhakim

doi:10.1016/j.jep.2021.114124

Cited by 21 publications

(10 citation statements)

References 81 publications

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“…The anti-inflammatory properties of D. microcarpum aqueous extracts, which contain polyphenolic compounds such as vanillic acid, gallic acid, and protocatechuic acid, imply that they are promising herbal remedies for pain and inflammation management [ 107 ]. Increased blood flow, increased cellular metabolism, vasodilatation, release of soluble mediators, extravasation of fluids, and cellular influx are all common symptoms of inflammation, and these mechanisms are the same and are independent of the triggering cause [ 108 ]. Arachidonic acid and inflammatory mediators such as cytokines, serotonin, histamine, prostaglandins, and leukotrienes are released from cells in response to the inflammatory agent, which also increases vascular permeability and facilitates leukocyte migration to the site of inflammation [ 108 ].…”

Section: Resultsmentioning

confidence: 99%

Biological Activity and Chemical Composition of Detarium microcarpum Guill. and Perr—A Systematic Review

Abdulrahman

2022

Advances in Pharmacological and Pharmaceutical Sciences

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Historically, natural products have been the principal source of medications for the treatment of human diseases. Traditional medical practitioners employ Detarium microcarpum as a treatment for diabetes, malaria, wounds, inflammation, and even cancer. This study emphasizes the importance of harmonizing D. microcarpum research so that results from various sources may be directly compared to reach a scientific conclusion. We searched Google Scholar, Science Direct, Google.com, Wiley, PubMed, Hindawi, and Springer for research papers on Detarium microcarpum. This analysis excludes untrustworthy online data, thesis papers, and review publications on D. microcarpum. The leaves and stem bark were shown to have high antioxidant, anti-inflammatory, antibacterial, antidiabetic, and anticancer properties. The study also discovered that too much consumption is harmful. Polyphenols and flavonoids were the most commonly reported compounds. However, human safety and efficacy are yet to be fully evaluated, and further well-designed clinical trials are needed to confirm preclinical findings. The leaves and stem bark extracts and isolated compound mechanism of action should be investigated. It is necessary to set a standard dose and ensure its safety.

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Section: Resultsmentioning

confidence: 99%

Biological Activity and Chemical Composition of Detarium microcarpum Guill. and Perr—A Systematic Review

Abdulrahman

2022

Advances in Pharmacological and Pharmaceutical Sciences

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“…It is used in different countries, especially in Morocco, to treat several disorders in humans. It is also used as an insecticidal and anti-parasitic ( 114 ).…”

Section: Resultsmentioning

confidence: 99%

Ethnoveterinary Medicine and Ethnopharmacology in the Main Transhumance Areas of Castilla-La Mancha (Spain)

et al. 2022

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In this study, we document the practices of ethnoveterinary medicine and ethnopharmacology in the context of traditional transhumance routes that cross Castilla La Mancha from north to south. Transhumance is a type of grazing system that allows advantage to be taken of winter pastures (wintering places) and summer pastures by seasonal movement, twice a year, of cattle and their shepherds. Our study is based on over 200 interviews (from 1994 to 2021) conducted in 86 localities along eight major transhumance routes “cañadas reales” and 25 other minor transhumance routes, and involved 210 informants, 89 single and 121 groups, and 562 individuals, of which the majority were men. Sixty-three recorded pathologies and their treatments are discussed. Two hundred and two species and substances, belonging to 92 different families, have been recorded from the interviews, of which most are plants. Amid the toxic plant species, the most cited in the interviews are Erophaca baetica (L.) Boiss., Lupinus angustifolius L., and Oenanthe crocata L. Some of the species reported as toxic were reservoirs of pathogens or markers for dangerous areas. One of the fields most widely covered in our study is that of prevention, protection, and control of endo- and ectoparasites. This control is carried out mainly by means of aromatic plants. As a polyvalent species, Daphne gnidium L. is outstanding, and it contributes one-tenth of the records of our study. Among the species of fundamentally therapeutic use, Cistus ladanifer L. stands out by far. Principal Coordinate Analysis (PCoA) based on the repertories of ingredients, separates the routes whose most important sections run through siliceous terrain with its characteristic flora, especially in the provinces of Ciudad Real and Toledo, from the routes that run through the limestone terrain of Albacete and Cuenca, and link the Eastern Mancha and the “Serranía de Cuenca” with Andalusia and the Spanish Levant.

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“…[23][24][25] In different Morocco regions, the leaves of D. gnidium are used for hair care. [26] In their study, Fahem et al [27] evaluated the efficacy of methanolic extract obtained from D. gnidium against biocorrosion caused by sulfate-reducing bacteria (SRB) on mild steel in SRB consortium. The authors found that the extract exhibited a significant inhibition efficacy against SRB-induced corrosion, making it a promising candidate for use as a natural inhibitor in industries that use mild steel.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical evaluation of Daphne gnidium extract's antioxidant capacity and its potential for mild steel corrosion protection in NaCl medium

Zarki,

Elmourabit,

Ben Seddik

et al. 2023

Materials & Corrosion

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In this study, the leaf extract of the plant Daphne gnidium L. (Thymemeacea) was used as a corrosion inhibitor for mild steel in 0.1 M NaCl. The content of total polyphenols was evaluated by UV visible spectrophotometry and with cyclic voltammetry. The results show that the extract contains a high content of total phenols estimated at 90.26 (mg GAE/g). Besides this, the plant extract was characterized via Fourier transform infrared spectroscopy. Electrochemical impedance spectroscopy and polarization techniques were used to investigate the extract's anticorrosive performance. The results indicated that the addition of 3% of the extract increased the inhibition efficiency to 90.8% after 4 h of immersion. In addition, the results of the polarization tests showed that the extract acted as a mixed‐type inhibitor, mainly affecting the anodic reaction. Scanning electron microscopy was used to study the morphology of the metal surface. The results revealed a less corrosion impact on mild steel in an inhibited solution.

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Ethnomedicinal use, phytochemistry, pharmacology, and toxicology of Daphne gnidium: A review

Cited by 21 publications

References 81 publications

Biological Activity and Chemical Composition of Detarium microcarpum Guill. and Perr—A Systematic Review

Biological Activity and Chemical Composition of Detarium microcarpum Guill. and Perr—A Systematic Review

Ethnoveterinary Medicine and Ethnopharmacology in the Main Transhumance Areas of Castilla-La Mancha (Spain)

Electrochemical evaluation of Daphne gnidium extract's antioxidant capacity and its potential for mild steel corrosion protection in NaCl medium

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