Ethnomedicinal use, phytochemistry, pharmacology, and toxicology of Ajuga iva (L.,) schreb

Bouyahya, Abdelhakim; Omari, Nasreddine El; Elmenyiy, Nawal; Guaouguaou, Fatima-Ezzahrae; Balahbib, Abdelaali; El-Shazly, Mohamed; Chamkhi, Imane

doi:10.1016/j.jep.2020.112875

Cited by 31 publications

(29 citation statements)

References 79 publications

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Section: Introductionmentioning

confidence: 99%

“…Currently, the identification of novel bioactive molecules with pharmacological effects is a promising strategy of research to combat several pathologies 1‐3 . Medicinal plants biosynthesize numerous bioactive compounds including terpenoids, flavonoids and alkaloids as secondary metabolites 1,4 . These metabolites in particularly essential oils (Eos) are endowed with important biological activities including anticancer, antimicrobial, antioxidant, anti‐parasitic, anti‐inflammatory and antidiabetic properties 3,5‐11 …”

Section: Introductionmentioning

confidence: 99%

“…Ajuga genus contains several medicinal plants which are used in traditional plants worldwide 14‐16 . Amongst these plants, Ajuga iva (L.,) Schreb, known in Morocco by its vernacular name of “ Chendgoura” , is a medicinal plant which belong to Lamiaceae family 1 . This species has been used traditionally in Morocco to treat several illnesses such as diabetes mellitus 17,18 .…”

Section: Introductionmentioning

confidence: 99%

“…Biological investigations of A iva extracts showed that this plant exhibited antimicrobial, 19 anti‐parasitic, 20 antidiabetic, 21 anticancer, antioxidant, anti‐hypertension 22 and anti‐inflammatory 23 effects. Moreover, volatile compounds of A iva essential oils (AIEO) have also shown antibacterial, antioxidant, hepatoprotective and antiviral activities against adenovirus type 5, coxsackievirus type B‐3, respiratory syncytial virus type B and herpes simplex virus type 2 1,24‐26 …”

Section: Introductionmentioning

confidence: 99%

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Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Bouyahya

Omari

Belmehdi

et al. 2020

Flavour & Fragrance J

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Ajuga iva (A iva) is a medicinal plant used mainly in traditional medicine. This study was aimed to identify the volatile compounds of A iva essential oils (AIEO) at three developmental periods, and to evaluate their pharmacological properties. Chemical volatile compounds were identified by GC/MS analysis. Twenty‐eight volatile components were identified, belonging mainly to oxygenated monoterpenes and hydrocarbons monoterpenes. Carvacrol, octadecane, methyl chavicol were the major volatile components of AIEO at the three phenological stages. FRAP, DPPH and ABTS assays were adopted to estimate the antioxidant effects. AIEO at the vegetative stage exhibited important antioxidant effects with IC50 = 52.43 μg/mL (DPPH), IC50 = 115.22 μg/mL (FRAP), and, IC50 = 143.40 μg/mL (ABTS). The antidiabetic activity was evaluated in vitro by the inhibition of α‐amylase and α‐glucosidase. AIEO at the vegetative stage was the most active as an enzyme inhibitor of α‐amylase (IC50 = 101.727 μg/mL) and α‐glucosidase (IC50 = 86.93 μg/mL). The dermatoprotective effect was investigated by the in vitro inhibition of tyrosinase and elastase activities. AIEO at the vegetative stage showed the lowest IC50 inhibition values against tyrosinase (IC50 = 87.49 μg/mL) and elastase (IC50 = 192.21 μg/mL). Antifungal properties of AIEO were investigated on Trichophyton violaceum, T tonsurans and T mentagrophytes. The three EOs of A iva exhibited important inhibitions of the tested dermatophytes. The findings of this work showed that phenological stages affect significantly the volatile compounds of A iva, and these fluctuations influence mainly the biological properties. Moreover, further investigations concerning in vivo pharmacodynamic and pharmacokinetic investigations as well as clinical trials of these identified compounds could develop antidiabetic, dermatoprotective and anti‐dermatophyte drugs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Bouyahya

Omari

Belmehdi

et al. 2020

Flavour & Fragrance J

Self Cite

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“…One of the many beneficial effects of flavonoids is their antiatherogenic effect [ 94 ]. Numerous studies have been conducted in order to explain this protective effect of flavonoids [ 95 , 96 , 97 , 98 ].…”

Section: The Flavonoid’s Mechanism Of Action In Different Pathologmentioning

confidence: 99%

The Effects of Flavonoids in Cardiovascular Diseases

et al. 2020

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Flavonoids are metabolites of plants and fungus. Flavonoid research has been paid special attention to in recent times after the observation of their beneficial effects on the cardiovascular system. These favorable effects are exerted by flavonoids mainly due to their antioxidant properties, which result from the ability to decrease the oxidation of low-density lipoproteins, thus improving the lipid profiles. The other positive effect exerted on the cardiovascular system is the ability of flavonoids to produce vasodilation and regulate the apoptotic processes in the endothelium. Researchers suggested that these effects, including their anti-inflammatory function, are consequences of flavonoids’ potent antioxidant properties, but recent studies have shown multiple signaling pathways linked to them, thus suggesting that there are more mechanisms involved in the beneficial effect of the flavonoids on the human body. This review aims to present the latest data on the classification of these substances, their main mechanisms of action in the human body, and the beneficial effects on the physiological and pathological status of the cardiovascular system.

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Identification of Ajuga Iva Extracts as Potential Candidates for Antidysmenorrhea Targeting Human COX2 and PGE2S‐1 through In Vitro and In Silico Drug Repurposing Approach

Djelti,

Berkane,

Alharbi

et al. 2024

ChemistrySelect

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Ajuga Iva, renowned in ethnomedicine, possesses various pharmacological properties, attributed to its diverse phytochemical profile. Despite its therapeutic potential, little research has examined the efficacy of Ajuga Iva in the treatment of dysmenorrhea, a prevalent inflammatory disorder that affects a significant number of adult women around the world, This study aims to explore the anti‐inflammatory properties of Ajuga Iva in the context of treating dysmenorrhea through a combined in vitro and in silico drug repurposing approach. In vitro assays evaluated the anti‐inflammatory efficacy of the plant extracts, revealing significant activity in inhibiting protein denaturation and heat‐induced haemolysis. Molecular docking studies identified potential bioactive phytochemicals, including Apigenin, Luteolin, Naringenin, and Quercetin, interacting with COX‐2 and PGES‐1, key enzymes in dysmenorrhea‐associated inflammatory pathways. Molecular dynamics simulations supported these interactions. Ajuga Iva methanolic extract exhibited significant anti‐inflammatory activity, as shown by its ability to inhibit protein denaturation by 80.68% at 1000 (μg/m) and heat induced haemolysis by 83.41% at 2000 (μg/m). Ajuga Iva bioactive phytochemicals showed promising interactions with COX‐2 and PGES‐1, suggesting their role in the plant's anti‐inflammatory mechanism. This research underscores the promising anti‐inflammatory activities of Ajuga Iva by inhibiting COX‐2 and PGE2S‐1, offering valuable insights for future therapeutic applications.

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Ethnomedicinal use, phytochemistry, pharmacology, and toxicology of Ajuga iva (L.,) schreb

Cited by 31 publications

References 79 publications

Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

The Effects of Flavonoids in Cardiovascular Diseases

Identification of Ajuga Iva Extracts as Potential Candidates for Antidysmenorrhea Targeting Human COX2 and PGE2S‐1 through In Vitro and In Silico Drug Repurposing Approach

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