Ethnomedicinal use, phytochemistry, pharmacology, and food benefits of Thymus capitatus

Bouyahya, Abdelhakim; Chamkhi, Imane; Guaouguaou, Fatima-Ezzahrae; Benali, Taoufiq; Balahbib, Abdelaali; Omari, Nasreddine El; Taha, Douae; El-Shazly, Mohamed; Menyiy, Naoual El

doi:10.1016/j.jep.2020.112925

Cited by 39 publications

(32 citation statements)

References 68 publications

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“…As regards the effect of carvacrol against N. solani, the MIC was 0.21 mg/mL. Moreover, earlier works reported closer MIC value For M. nivale treated with essential oils contained carvacrol [38][39][40][41]. The difference in MICs can be due to the use of different methods, in particular, the concentration of spore inoculum, effects of incubation temperature, time of reading on broth dilution, the use of detergents or solvents for carvacrol dispersion, which affect the antifungal activity [26,42].…”

Section: Discussionmentioning

confidence: 83%

Carvacrol: A Promising Environmentally Friendly Agent to Fight Seeds Damping-Off Diseases Induced by Fungal Species

et al. 2021

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Background: Gramineae damping-off disease is a growing problem worldwide, which affects a large range of seedlings in nurseries, glasshouses, gardens, crops, forests and untimely generates a heavy economic impact on the agriculture and related sectors. Objectives: The present study was conducted to evaluate the preventive potential of carvacrol on germination of Fusarium oxysporum, Neocosmospora solani, and Microdochium nivale spores as responsible agents for Lolium perenne seeds damping-off disease. Material and methods: Macrodilution method in agar medium, spore germination, spore destruction, and preventive treatment bioassays were used to achieve this goal. Results: The minimum inhibitory concentration (MIC) of carvacrol vs. tested strains existed in the range of 0.25–0.5 mg/mL. Carvacrol used in concentrations ranging from 0.2 to 0.4 mg/mL inhibited the germination of all fungal spores in a dose-dependent manner. Carvacrol showed a very strong sporicidal effect against all studied fungal strains, and this effect was well confirmed by microscopic observations. The percentage of growth inhibition was found to be strictly correlated to carvacrol dose up vs. all strains. Carvacrol increased the emergence of L. perenne seeds when compared to both uninfested and infested seeds. Conclusion: Based on the results obtained, carvacrol fulfills the requirement for being a natural alternative agent to fight Gramineae seedlings’ damping-off caused by fungal species without adverse effects on the plants.

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Section: Discussionmentioning

confidence: 83%

Carvacrol: A Promising Environmentally Friendly Agent to Fight Seeds Damping-Off Diseases Induced by Fungal Species

et al. 2021

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“…Searching for bioactive compounds from medicinal plants is not a new African research initiative. Even so, in previous studies, two key components were lacking in our view: (i) Most of the studies have only been national or regional (e.g., Bouyahya et al ., 2020; Kamau et al ., 2016; Okot et al ., 2020; Oladeji et al ., 2020; Patrick et al ., 2015; Spiegler., 2020; Twilley et al ., 2020). To achieve the same effect and coverage as the traditional Chinese medicine effort, a continental coverage is needed.…”

Section: Conclusion and The Way Forwardmentioning

confidence: 99%

Plant genomics in Africa: present and prospects

et al. 2021

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Plants are the world's most consumed goods. They are of high economic value and bring many health benefits. In most countries in Africa, the supply and quality of food will rise to meet the growing population's increasing demand. Genomics and other biotechnology tools offer the opportunity to improve subsistence crops and medicinal herbs in the continent. Significant advances have been made in plant genomics, which have enhanced our knowledge of the molecular processes underlying both plant quality and yield. The sequencing of complex genomes of African plant species, facilitated by the continuously evolving nextgeneration sequencing technologies and advanced bioinformatics approaches, has provided new opportunities for crop improvement. This review summarizes the achievements of genome sequencing projects of endemic African plants in the last two decades. We also present perspectives and challenges for future plant genomic studies that will accelerate important plant breeding programs for African communities. These challenges include a lack of basic facilities, a lack of sequencing and bioinformatics facilities, and a lack of skills to design genomics studies. However, it is imperative to state that African countries have become key players in the plant genome revolution and genome derived-biotechnology. Therefore, African governments should invest in public plant genomics research and applications, establish bioinformatics platforms and training programs, and stimulate university and industry partnerships to fully deploy plant genomics, particularly in the fields of agriculture and medicine.

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“…Thymol (2-isopropyl-5-methylphenol), a natural phenolic monoterpenoid obtained mainly from the Thymus species ( Trachyspermum ammi L. Sprague) [ 145 ], has been used in folk medicine to treat various ailments such as diabetes and respiratory disorders [ 147 ]. Thymol is a potent antioxidant and scavenger for hydroxyl radicals and superoxide anions [ 148 ].…”

Section: Monoterpenes In Diabetesmentioning

confidence: 99%

In Vitro and In Vivo Antidiabetic Potential of Monoterpenoids: An Update

et al. 2021

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Diabetes mellitus (DM) is a chronic metabolic condition characterized by persistent hyperglycemia due to insufficient insulin levels or insulin resistance. Despite the availability of several oral and injectable hypoglycemic agents, their use is associated with a wide range of side effects. Monoterpenes are compounds extracted from different plants including herbs, vegetables, and fruits and they contribute to their aroma and flavor. Based on their chemical structure, monoterpenes are classified into acyclic, monocyclic, and bicyclic monoterpenes. They have been found to exhibit numerous biological and medicinal effects such as antipruritic, antioxidant, anti-inflammatory, and analgesic activities. Therefore, monoterpenes emerged as promising molecules that can be used therapeutically to treat a vast range of diseases. Additionally, monoterpenes were found to modulate enzymes and proteins that contribute to insulin resistance and other pathological events caused by DM. In this review, we highlight the different mechanisms by which monoterpenes can be used in the pharmacological intervention of DM via the alteration of certain enzymes, proteins, and pathways involved in the pathophysiology of DM. Based on the fact that monoterpenes have multiple mechanisms of action on different targets in in vitro and in vivo studies, they can be considered as lead compounds for developing effective hypoglycemic agents. Incorporating these compounds in clinical trials is needed to investigate their actions in diabetic patients in order to confirm their ability in controlling hyperglycemia.

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Ethnomedicinal use, phytochemistry, pharmacology, and food benefits of Thymus capitatus

Cited by 39 publications

References 68 publications

Carvacrol: A Promising Environmentally Friendly Agent to Fight Seeds Damping-Off Diseases Induced by Fungal Species

Carvacrol: A Promising Environmentally Friendly Agent to Fight Seeds Damping-Off Diseases Induced by Fungal Species

Plant genomics in Africa: present and prospects

In Vitro and In Vivo Antidiabetic Potential of Monoterpenoids: An Update

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