Ethnomedicinal uses, nutritional composition, phytochemistry and potential health benefits of Carica papaya

Ugbogu, Eziuche A.; Dike, Emmanuel D.; Uche, Miracle Ebubechi; Etumnu, Lotanna R.; Okoro, Benedict C.; Ugbogu, Ositadinma C.; Adurosakin, Oluwapelumi E.; Chinma, Chiemela Enyinna; Ohaeri, Esther; Iweala, Emeka J.

doi:10.1016/j.prmcm.2023.100266

Cited by 11 publications

(4 citation statements)

References 91 publications

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“…Carica papaya demonstrates remarkable efficacy in treating various ailments, attributed to the abundance of diverse phytoconstituents found in nearly all parts of the plant. Literature review that the plant shows the following pharmacological activities [56],…”

Section: Pharmacological Properties Of Carica Papaya Linnmentioning

confidence: 99%

Therapeutic Potential of Carica papaya Linn.: A Comprehensive Review of Its Pharmacological Properties and Health Benefits, with Emphasis on Dengue Fever Healing

Fernando,

Peiris,

Senadeera

et al. 2024

APRJ

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For thousands of years, people have used various plant products, foods, spices, and herbs to treat and prevent illnesses. Sri Lankans have been using traditional and folk medicine to satisfy their basic health needs from the earliest days. Carica papaya Linn. (Caricaceae) is a commercially grown exotic plant in Sri Lanka. The entire plant, including the fruits both ripened and green, leaves, roots, peel, seed, and pulp, was used as medicine in traditional medicinal systems. Plant parts of Carica papaya Linn. were frequently used by ancient Sri Lankans to treat diabetes mellitus, hypertension, cancer, dengue fever, skin infections, renal disorders, and infections caused by bacteria, fungi, parasites, and viruses. Dengue fever is the most prevalent and significant arthropod-borne viral disease in humans, and it is extensively spread throughout Sri Lanka. Carica papaya Linn. extracts have been used to treat dengue patients to recover from its complications, which include thrombocytopenia, hemolysis, and leukopenia. Studies reveal that the papaya leaf extract can neutralize plasma with the dengue virus, reduce platelet aggregation, and increase the production of the enzyme ALOX12, which promotes platelet production. Moreover, the extract also upregulates the platelet-activating factor receptor (PTAFR) gene and inhibits serine proteases NS2B and NS3 involved in dengue virus replication. In this review, we have discussed extensively the ethnomedicinal and pharmacological properties of Carica papaya while highlighting its remarkable potency in healing dengue.

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Section: Pharmacological Properties Of Carica Papaya Linnmentioning

confidence: 99%

Therapeutic Potential of Carica papaya Linn.: A Comprehensive Review of Its Pharmacological Properties and Health Benefits, with Emphasis on Dengue Fever Healing

Fernando,

Peiris,

Senadeera

et al. 2024

APRJ

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“…rubrum rhizoma) contains essential oils and quite a variety of bioactive compounds, such as shogaols, paradols and gingerols. These compounds are quite active as antiinflammatory, anti-cancer, and antifungal (Anh et al 2020) Dila 'papaya' (Carica papaya) is rich in nutrition containing calories, carbohydrates, protein, fat, fiber, antioxidants, vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, folic acid, vitamin C, vitamin E and vitamin K. Carica papaya is beneficial for digestion, improving the immune system, nourishing heart, skin, and hair, and healing wounds (Ugbogu et al 2023).…”

Section: Cultural Practices Of Traditional Medicine By Tetun Tribementioning

confidence: 99%

The diversity, lexicon and cultural practices of family medicinal plants by Tetun Tribe in Malaka, East Nusa Tenggara, Indonesia

HESTIYANA,

TAEK,

RIANI

et al. 2023

Biodiversitas

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Abstract. Hestiyana, Taek MM, Riani, Jahdiah, Yayuk R. 2023. The diversity, lexicon and cultural practices of family medicinal plants by Tetun Tribe in Malaka, East Nusa Tenggara, Indonesia. Biodiversitas 24: 5359-5367. Medicinal plants are part of traditional culture used by humans to cure illness and improve health. The knowledge, perception and tradition of medicinal plants are unique to certain ethnic groups and therefore imbedded in the local language and passed down for generations. This study aims to describe the diversity and lexicon of family medicinal plants (TOGA) and its cultural practices by Tetun ethnic in Malaka District, East Nusa Tenggara Province, Indonesia. This study used a qualitative descriptive method with an ethnolinguistic approach and combined primary and secondary data. Primary data was collected by documenting a list of lexicons of medicinal plants in TOGA by the Tetun ethnic obtained from traditional healers, old people and community leaders through a series of interviews in the field. Secondary data was obtained from published sources related to this theme of research. The results of the study show that there are 32 lexicons of medicinal plants used by Tetun Tribe. These lexicons can be classified as basic words or monomorphemics (20 plants) and phrases (12 plants). Medicinal plant parts used include roots, rhizomes, tubers, stems, bark, leaves, flowers, fruits and seeds. Methods of preparation of medicinal plants are by boiling, grinding, then rubbing on the affected body part, chewing and brewing with hot water. The Tetun’s knowledge of health benefits of medicinal plants is in line with scientific evidences.

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“…papaya leaf extracts (Table 4). These substances have a known hypoglycaemic impact [7,9,39,49,[100][101]. papaya are listed in Table 5.…”

Section: Phytoconstituents With Antidiabetic Activitymentioning

confidence: 99%

Antidiabetic potential of Carica papaya L. and its constituents: From folkloric uses to products development

Ogunlakin,

Onifade,

Ojo

et al. 2023

BCHD

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Carica papaya L. is a plant that has a reputation for being antidiabetic. This review is focused on antidiabetic properties of Carica papaya. A comprehensive search was performed using various electronic databases including Researchgate, PubMed, Google Scholar, Biomedgrid.com and ScienceDirect. 224 publications were downloaded, out of which one 107 relevant publications were reviewed. The fruit, leaves, and seeds of this plant have been reported to possess antidiabetic properties at different dosages via in vivo, in vitro, and ex vivo studies. Fortified papaya cake, MPPB flour (containing C. papaya), and brotowali extract (fortified papaya leaves and sugarcane extracts) displayed significant hypoglycaemic effect. From a clinical trial, the fruit consumed after meals significantly reduced blood glucose level in a quasi-experimental study. Some bioactive compounds found in the plant's extracts have been linked to the antidiabetic effect of the plant. It has been discovered that the leaf extract contains hypoglycemic saponins, alkaloids, flavonoids, triterpenoids, and tannins. Few compounds with antidiabetic characteristics have been identified from the extracts of this plant's seeds, including hexadecanoic acid, methyl ester, 11-octadecenoic acid, N, N-dimethyl-, n-hexadecanoic acid, and oleic acid. Therefore, pawpaw fruit consumption might help to mitigate the symptoms of diabetes. For the development of new natural remedies for management and prevention of diabetes, additional studies, particularly those on the isolation of antidiabetic principles from various portions of C. papaya, will be crucial.Keywords:Carica papaya; Antidiabetics; Phytoconstituents; Clinical trials; Papaya products

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Ethnomedicinal uses, nutritional composition, phytochemistry and potential health benefits of Carica papaya

Cited by 11 publications

References 91 publications

Therapeutic Potential of Carica papaya Linn.: A Comprehensive Review of Its Pharmacological Properties and Health Benefits, with Emphasis on Dengue Fever Healing

Therapeutic Potential of Carica papaya Linn.: A Comprehensive Review of Its Pharmacological Properties and Health Benefits, with Emphasis on Dengue Fever Healing

The diversity, lexicon and cultural practices of family medicinal plants by Tetun Tribe in Malaka, East Nusa Tenggara, Indonesia

Antidiabetic potential of Carica papaya L. and its constituents: From folkloric uses to products development

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