Ethnomedicinal uses, phytochemistry, and biological activities of plants of the genus Gynura

Bari, Md. Sazzadul; Khandokar, Labony; Haque, Ehfazul; Romano, Barbara; Capasso, Raffaele; Seidel, Véronique; Haque, Md. Areeful; Rashid, Mohammad A.

doi:10.1016/j.jep.2021.113834

Cited by 58 publications

(36 citation statements)

References 101 publications

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“…However, due to the side effects from long-term application [ 112 ], anthraquinone drugs are not recommended as the first choice for constipation clinically. The genus Gynura was also reported to treat constipation [ 114 ]. Except single herbal medicines, many herbal formulas also alleviate constipation.…”

Section: Microbial-associated Treatments and Research Strategies In Fcmentioning

confidence: 99%

Roles of Gut Microbiota and Metabolites in Pathogenesis of Functional Constipation

Wang

Yao

2021

Evidence-Based Complementary and Alternative Medicine

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Functional constipation (FC), a condition characterized by heterogeneous symptoms (infrequent bowel movements, hard stools, excessive straining, or a sense of incomplete evacuation), is prevalent over the world. It is a multifactorial disorder and can be categorized into four subgroups according to different pathological mechanisms: normal transit constipation (NTC), slow transit constipation (STC), defecatory disorders (DD), and mixed type. Recently, growing evidence from human and animals has pointed that there was a strong association between gut microbiota and FC based on the brain-gut-microbiome axis. Studies have reported that the main characteristics of gut microbiota in FC patients were the relative decrease of beneficial bacteria such as Lactobacillus and Bifidobacterium, the relative increase of potential pathogens, and the reduced species richness. Gut microbiota can modulate gut functions through the metabolites of bacterial fermentation, among which short-chain fatty acids (SCFAs), secondary bile salts (BAs), and methane occupied more important positions and could trigger the release of gut hormones from enteroendocrine cells (EECs), such as 5-hydroxytryptamine (5-HT), peptide YY (PYY), and glucagon-like peptide-1 (GLP-1). Subsequently, these gut hormones can influence gut sensation, secretion, and motility, primarily through activating specific receptors distributed on smooth muscle cells, enteric neurons, and epithelial cells. However, research findings were inconsistent and even conflicting, which may be partially due to various confounding factors. Future studies should take the associated confounders into consideration and adopt multiomics research strategies to obtain more complete conclusions and to provide reliable theoretical support for exploring new therapeutic targets.

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Section: Microbial-associated Treatments and Research Strategies In Fcmentioning

confidence: 99%

Roles of Gut Microbiota and Metabolites in Pathogenesis of Functional Constipation

Wang

Yao

2021

Evidence-Based Complementary and Alternative Medicine

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“…Quercetin is a naturally occurring phenolic of vegetables, fruits, and Gynura plants that may protect against a number of diseases of aging including osteoporosis and heart disease [ 115 , 116 ]. Wang et al [ 117 ] showed that quercetin activated the SIRT1 autophagy signalling pathway and reduced TBHP-induced ROS production, thereby inhibiting NP cell apoptosis and matrix catabolism.…”

Section: Natural Pharmacological Productsmentioning

confidence: 99%

Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration

Chen

Zhang

Liu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Intervertebral disc degeneration (IDD) is one of the main causes of low back pain (LBP), which severely reduces the quality of life and imposes a heavy financial burden on the families of affected individuals. Current research suggests that IDD is a complex cell-mediated process. Inflammation, oxidative stress, mitochondrial dysfunction, abnormal mechanical load, telomere shortening, DNA damage, and nutrient deprivation contribute to intervertebral disc cell senescence and changes in matrix metabolism, ultimately causing IDD. Natural products are widespread, structurally diverse, afford unique advantages, and exhibit great potential in terms of IDD treatment. In recent years, increasing numbers of natural ingredients have been shown to inhibit the degeneration of nucleus pulposus cells through various modes of action. Here, we review the pharmacological effects of natural products on nucleus pulposus cells and the mechanisms involved. An improved understanding of how natural products target signalling pathways will aid the development of anti-IDD drugs. This review focuses on potential IDD drugs.

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“…Globally, many studies have been conducted to check their effectiveness, with some of the results leading to plant‐based medicines (Goni et al., 2021; Hossen et al., 2021; Sofowora et al., 2013). The growing global burden of cancer requires a new treatment option, while herbal medicine presents a potential alternative to western medicine for cancer treatment (Ahmed et al., 2020; Bari et al., 2021; de Carvalho et al., 2020). A large number of plant species are now being used in cancer treatment or prevention.…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative and antioxidant potentials of bioactive edible vegetable fraction of Achyranthes ferruginea Roxb. in cancer cell line

Reza

Haque

Sarker

et al. 2021

Food Science & Nutrition

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In the present study, the aerial parts of Achyranthes ferruginea underwent investigation of their in vitro antioxidant and free radical‐scavenging activities in cell‐free conditions, their phytoconstituents using gas chromatography‐mass spectrometry (GC‐MS), and their cytotoxic activity in HeLa cells. A. ferruginea was extracted with 80% methanol and successively fractionated with solvents to yield petroleum ether (PEF), chloroform (CHF), ethyl acetate (EAF), and aqueous (AQF) fractions. GC‐MS analysis revealed that CHF contained ten phytoconstituents, including different forms of octadecanoic acid methyl esters. The total antioxidant and ferric‐reducing antioxidant capacities of the extracts and the standard catechin (CA) were as follows: CA >CHF >PEF >CME (crude methanolic extract) >EAF >AQF, and CA >CHF >EAF >PEF >AQF >CME, respectively. CHF showed the highest DPPH‐free radical‐scavenging activity, with a median inhibitory concentration of 10.5 ± 0.28 µg/ml, which was slightly higher than that of the standard butylated hydroxytoluene (12.0 ± 0.09 µg/ml). In the hydroxyl radical‐scavenging assay, CHF showed identical scavenging activity (9.25 ± 0.73 µg/ml) when compared to CA (10.50 ± 1.06 µg/ml). Moreover, CHF showed strong cytotoxic activity (19.95 ± 1.18 µg/ml) in HeLa cells, which was alike to that of the standards vincristine sulfate and 5‐fluorouracil (15.84 ± 1.64 µg/ml and 12.59 ± 1.75 µg/ml, respectively). The in silico study revealed that identified compounds were significantly linked to the targets of various cancer cells and oxidative enzymes. However, online prediction by SwissADME, admetSAR, and PASS showed that it has drug‐like, nontoxic, and potential pharmacological actions.

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Ethnomedicinal uses, phytochemistry, and biological activities of plants of the genus Gynura

Cited by 58 publications

References 101 publications

Roles of Gut Microbiota and Metabolites in Pathogenesis of Functional Constipation

Roles of Gut Microbiota and Metabolites in Pathogenesis of Functional Constipation

Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration

Antiproliferative and antioxidant potentials of bioactive edible vegetable fraction of Achyranthes ferruginea Roxb. in cancer cell line

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