Ethnopharmacological study of the genus Coffea and compounds of biological importance

Gallardo-Ignacio, J.; Nicasio-Torres, P.; Santibáñez, A.; Cabrera-Hilerio, S.L.; Cruz-Sosa, F.

doi:10.24275/rmiq/bio2856

Cited by 2 publications

(9 citation statements)

References 52 publications

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“…These compounds are related to the cup quality of the coffee drink, which gives it astringency and flavor [15,17]. The 1 H and 13 C nuclear magnetic resonance (NMR) analysis of the compound isolated from the MRC infusion validated that it corresponds to CGA; chemical displacements and coupling constants (Table 2) correspond to those reported in the literature for this compound [18]. Among the green beans of C. arabica varieties analyzed (Table 3), the Typica variety has the lowest contents of CGA (36.81 mg/g) and caffeine (1.16 mg/g).…”

Section: Chemical Analysismentioning

confidence: 99%

“…caffeine, although other compounds that influence antioxidant properties, such epicatechin, catechin, and anthocyanins, have also been reported. Oxidative stress i trigger for chronic degenerative diseases such as arthritis, diabetes mellitus, and canc Important pharmacological effects such as anti-inflammatory, regulation of glucose a lipid metabolisms, and anticancer have been reported for coffee beverages and CG [13,15,40,43]. Caffeine exerts physiological effects associated with the functions of t central nervous system [44].…”

Section: Biological Materialsmentioning

confidence: 99%

“…The MRC extract (2 g) was fractionated by open column chromatography (2.7 cm diameter × 44 cm high), packed with 20 g of RP-18 silica gel (Supelco, Germany), and eluted with a gradient system of H 2 O: CH 3 CN. Aliquots of 10 mL were collected with an initial system of 100% H 2 O (1-10) and polarity changes from CH 3 CN at 5% (11)(12)(13)(14)(15), CH 3 CN at 50% (16)(17), and CH 3 OH at 100% (18). The fractions were analyzed by reverse-phasethin layer chromatography with an elution system of 90:10 H 2 O:CH 3 CN and displayed in a UV lamp (UVP UVGL-58) at λ = 254 nm and λ = 365 nm.…”

Section: Chemical Fractionation Of Mrc Infusionmentioning

confidence: 99%

“…The fractions were analyzed by reverse-phasethin layer chromatography with an elution system of 90:10 H 2 O:CH 3 CN and displayed in a UV lamp (UVP UVGL-58) at λ = 254 nm and λ = 365 nm. Aliquots with a similar chromatographic profile (13)(14)(15) were grouped and diluted in dimethyl sulfoxide to be analyzed by NMR of 1 H and 13 C spectra at 100 MHz, 2-dimensional (2-D) correlated spectroscopy (COSY), heteronuclear simple quantum coherence (HSQC), and heteronuclear multiple bond coherence (HMBC) at 400 MHz on Varian INOVA-400 equipment.…”

Section: Chemical Fractionation Of Mrc Infusionmentioning

confidence: 99%

“…1 H (400 MHz) and13 C NMR (100 MHz) Spectroscopic Data of Chlorogenic Acid (MeOH-d 4 , δ, ppm, J/Hz).…”

mentioning

confidence: 99%

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Chemical and Biological Characterization of Green and Processed Coffee Beans from Coffea arabica Varieties

et al. 2023

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Coffee is one of the most consumed beverages in the world; its production is based mainly on varieties of the Coffea arabica species. Mexico stands out for its specialty and organic coffee. In Guerrero, the production is done by small indigenous community cooperatives that market their product as raw material. Official Mexico Standards stipulate the requirements for its commercialization within the national territory. In this work, the physical, chemical, and biological characterizations of green, medium, and dark roasted beans from C. arabica varieties were carried out. Analysis by HPLC showed higher chlorogenic acid (55 mg/g) and caffeine (1.8 mg/g) contents in the green beans of the Bourbon and Oro Azteca varieties. The caffeine (3.88 mg/g) and melanoidin (97 and 29 mg/g) contents increased according to the level of roasting; a dissimilar effect was found in the chlorogenic acid content (14.5 mg/g). The adequate nutritional content and the sensory evaluation allowed the classification of dark-roasted coffee as premium coffee (84.25 points) and medium-roasted coffee as specialty coffee (86.25 points). The roasted coffees presented antioxidant activity without cytotoxic effects; the presence of CGA and caffeine supports the beneficial effects of drinking coffee. The results obtained will serve as a basis for making decisions on improvements to the coffees analyzed.

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Section: Chemical Analysismentioning

confidence: 99%

Section: Biological Materialsmentioning

confidence: 99%

Section: Chemical Fractionation Of Mrc Infusionmentioning

confidence: 99%

Section: Chemical Fractionation Of Mrc Infusionmentioning

confidence: 99%

“…1 H (400 MHz) and13 C NMR (100 MHz) Spectroscopic Data of Chlorogenic Acid (MeOH-d 4 , δ, ppm, J/Hz).…”

mentioning

confidence: 99%

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Chemical and Biological Characterization of Green and Processed Coffee Beans from Coffea arabica Varieties

et al. 2023

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Molecular Simulation of Coffee Beans’ Natural Products as Lead Compounds for Stroke Remedy

Rubani,

Parikesit

2024

Engineering Headway

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The consumption of coffee has its health benefits and its risks, one of the risks is mostly related to cardiovascular diseases. One of the diseases is hypertension which is considered “the silent killer” as it is a serious condition which promotes other complications and typically has no symptoms for a period of time until it has done significant damage. Acute hypertension can lead to a stroke. It is a very serious medical condition where the blood flow to the brain is poor, causing the death of cells within the brain. Some medications, surgeries and other healthcare programs are capable of controlling stroke, but stroke still remains to be the main cause of death and disability in Indonesia. However, provided that the consumption is restrained, multiple studies show that coffee consumption actually can reduce the risk of getting a stroke, by consuming between 2 to 4 cups of coffee per day. Additionally, coffee can reduce the likelihood of blood clots from forming and is likely to alter the blood vessel physiology. Therefore, the current project will explore the possibility of utilization of bioactive compounds other than caffeine from coffee beans that can be implemented in a form of supplements to help in treating patients both with stroke symptoms and during the recovery phase. Protein docking analysis is an alternative way to search and predict for drug discovery. Through protein docking analysis we can gain information on the bioactive compounds and their respective interactions with the target. Based on the virtual screening pipeline, it is predicted that Dehydrokahweol could elicit possible lead for the anti-stroke activity.

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Ethnopharmacological study of the genus Coffea and compounds of biological importance

Abstract: totales del petróleo intemperizados en suelos y sedimentos (Biodegradation modeling of sludge bioreactors of total petroleum hydrocarbons weathering in soil and sediments)

Cited by 2 publications

References 52 publications

Chemical and Biological Characterization of Green and Processed Coffee Beans from Coffea arabica Varieties

Chemical and Biological Characterization of Green and Processed Coffee Beans from Coffea arabica Varieties

Molecular Simulation of Coffee Beans’ Natural Products as Lead Compounds for Stroke Remedy

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