Ethnopharmacology, Chemistry and Biological Properties of Four Malian Medicinal Plants

Malterud, Karl Egil

doi:10.3390/plants6010011

Cited by 31 publications

(29 citation statements)

References 67 publications

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“…Medicinal plants represent a significant source of therapeutic remedies, being also the basis of traditional or indigenous healing systems, still widely used by the majority of populations in many countries [ 1 , 2 ]. Recently, the ethnopharmacological potentials of these plant matrices have received important consideration by both scientists and the pharmaceutical industry towards complementing or even replacing conventional pharmacotherapies [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. Moreover, many of these plants have also been highlighted for their added-food value ability, providing a dual role, i.e., food flavor and bioactive compounds [ 3 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Plants of Genus Mentha: From Farm to Food Factory

Salehi

Stojanović-Radić

Matejić

et al. 2018

Plants

133

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Genus Mentha, a member of Lamiaceae family, encompasses a series of species used on an industrial scale and with a well-described and developed culture process. Extracts of this genus are traditionally used as foods and are highly valued due to the presence of significant amounts of antioxidant phenolic compounds. Many essential oil chemotypes show distinct aromatic flavor conferred by different terpene proportions. Mint extracts and their derived essential oils exert notable effects against a broad spectrum of bacteria, fungi or yeasts, tested both in vitro or in various food matrices. Their chemical compositions are well-known, which suggest and even prompt their safe use. In this review, genus Mentha plant cultivation, phytochemical analysis and even antimicrobial activity are carefully described. Also, in consideration of its natural origin, antioxidant and antimicrobial properties, a special emphasis was given to mint-derived products as an interesting alternative to artificial preservatives towards establishing a wide range of applications for shelf-life extension of food ingredients and even foodstuffs. Mentha cultivation techniques markedly influence its phytochemical composition. Both extracts and essential oils display a broad spectrum of activity, closely related to its phytochemical composition. Therefore, industrial implementation of genus Mentha depends on its efficacy, safety and neutral taste.

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Section: Introductionmentioning

confidence: 99%

Plants of Genus Mentha: From Farm to Food Factory

Salehi

Stojanović-Radić

Matejić

et al. 2018

Plants

133

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“…Terminalia chevalieri , Myrobalanus macroptera ) widespread in West Africa from Senegal to Cameroon [ 8 ]. In Mali, T. macroptera is one of the most cited plant used in traditional medicine to treat a large variety of diseases including malaria [ 9 ]. In addition, traditional remedies allow an affordable access to anti-malarial drugs for the most deprived [ 10 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

In vivo validation of anti-malarial activity of crude extracts of Terminalia macroptera, a Malian medicinal plant

Haïdara

Haddad

Dénou

et al. 2018

Malar J

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BackgroundPlasmodium falciparum malaria is still one of the most deadly pathology worldwide. Efficient treatment is jeopardized by parasite resistance to artemisinin and its derivatives, and by poor access to treatment in endemic regions. Anti-malarial traditional remedies still offer new tracks for identifying promising antiplasmodial molecules, and a way to ensure that all people have access to care. The present study aims to validate the traditional use of Terminalia macroptera, a Malian plant used in traditional medicine.MethodsTerminalia macroptera was collected in Mali. Leaves (TML) and roots ethanolic extracts (TMR) were prepared and tested at 2000 mg/kg for in vivo acute toxicity in Albino Swiss mice. Antiplasmodial activity of the extracts was assessed against a chloroquine resistant strain P. falciparum (FcB1) in vitro. In vivo, anti-malarial efficacy was assessed by a 4-day suppressive test at 100 mg/kg in two malaria murine models of uncomplicated malaria (Plasmodium chabaudi chabaudi infection) and cerebral malaria (Plasmodium berghei strain ANKA infection). Constituents of TMR were characterized by ultra-high-performance liquid chromatography coupled to high resolution mass spectrometry. Top ranked compounds were putatively identified using plant databases and in silico fragmentation pattern.ResultsLethal dose of TML and TMR were greater than 2000 mg/kg in Albino Swiss mice. According to the OECD’s Globally Harmonized System of Classification, both extracts are non-toxic orally. Antiplasmodial activity of T. macroptera extracts was confirmed in vitro against P. falciparum FcB1 strain with IC50 values of 1.2 and 1.6 µg/mL for TML and TMR, respectively. In vivo, oral administration of TML and TMR induced significant reduction of parasitaemia (37.2 and 46.4% respectively) in P. chabaudi chabaudi infected mice at the 7th day of infection compared to untreated mice. In the cerebral malaria experimental model, mice treated with TMR and TML presented respectively 50 and 66.7% survival rates at day 9 post-infection when all untreated mice died. Eleven major compounds were found in TMR. Among them, several molecules already known could be responsible for the antiplasmodial activity of the roots extract of T. macroptera.ConclusionsThis study confirms both safety and anti-malarial activity of T. macroptera, thus validating its traditional use.

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“…Medicinal plants studied are important for the evaluation of antimicrobial, antifungal, and antiviral activity in infectious diseases. Therefore, various medicinal plants may produce effects through more than one specific mechanism [111][112][113][114]. The results of…”

Section: Discussionmentioning

confidence: 99%

The Most Important Herbs Used in the Treatment of Sexually Transmitted Infections in Traditional Medicine

Nazer

Abbaszadeh

Darvishi

et al. 2019

SJMS

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Sexually transmitted diseases (STDs) or venereal diseases are transmitted through various methods of sexual intercourse (oral, vaginal, and anal). The predisposition to this type of diseases and infections depends on the immunity system of the body, so the lower the immunity system's strength, the greater the risk of Sexually transmitted infections (STIs). The most important pathogenic causes of STIs include bacteria, viruses, and parasites. Phytochemical investigations have shown that medicinal plants are a rich source of antioxidant compounds, biologically active compounds, phenols, etc. They can have an inhibitory effect on germs and infectious viruses and are very important for a variety of parasitic diseases, microbial infections, and STIs. Some of the most important medicinal plants that produce inhibitory effects on the growth and proliferation of pathogenic agents of the STIs were reported in the present article. Based on the results obtained from the review of numerous articles indexed in the databases the Institute for Scientific Information, Scopus, PubMed, Google Scholar, etc., a number of plants have been reported to be used in the treatment and prevention of genital tract diseases and STIs, and to produce antiviral and antimicrobial effects, including have examined the therapeutic and clinical effects of medicinal plants, and the use of their active ingredients to produce herbal drugs has been addressed. The results of phytochemical investigations have shown that the most important compounds of these plants include quercetin,

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Ethnopharmacology, Chemistry and Biological Properties of Four Malian Medicinal Plants

Cited by 31 publications

References 67 publications

Plants of Genus Mentha: From Farm to Food Factory

Plants of Genus Mentha: From Farm to Food Factory

In vivo validation of anti-malarial activity of crude extracts of Terminalia macroptera, a Malian medicinal plant

The Most Important Herbs Used in the Treatment of Sexually Transmitted Infections in Traditional Medicine

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