Ethnopharmacology of Ogliastra (Villagrande Strisaili, Sardinia, Italy)

Loi, Michele

doi:10.1016/s0367-326x(04)00047-4

Cited by 10 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…R. acetosa, R. acetosella, R. confertus, R. crispus, R. hydrolapathum and R. obtusifolius are commonly used in different kind of diseases treatments [2][3][4]. Preparations from the Rumex, especially due to their anti-inflammatory and antimicrobial activities, are useful in dermatology for skin infections [5][6][7][8][9], in inflammation of the gastrointestinal tract and digestive disorders [5,7,10,11], as laxative or antidiarrheal agents [7,[11][12][13][14] and as a treatment for upper respiratory tract diseases (nasal sinuses and throat) [15]. In the 70's decoctions from the fruits of R. crispus were especially accepted in the pediatric hospitals for their bacteriostatic and gentle antidiarrheal action [16,17].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of the extracts from fruits of Rumex L. species

et al. 2011

View full text Add to dashboard Cite

This study was designed primarily to investigate the antibacterial and antifungal activity of the extracts from fruits of six Rumex L. species: R. acetosa L., R. acetosella L., R. confertus Willd., R. crispus L., R. hydrolapathum Huds. and R. obtusifolius L. The 7 Grampositive and 7 Gram-negative bacteria strains and 5 fungal ones were tested by agar and broth dilution method. Determination of minimal inhibitory concentration (MIC) revealed that the extracts from R. confertus, R. crispus, R. hydrolapathum and R. obtusifolius exerted differential inhibitory effect on the growth of Gram-positive bacteria — staphylococci (MIC=62.5–125 µg/mL) and Gramnegative bacteria — Escherichia coli ATCC 3521, Proteus mirabilis, Pseudomonas aeruginosa (MIC=125→500 µg/mL); MIC values determined by agar dilution method were somewhat higher. The same extracts inhibited also the growth of fungi — Candida spp. or Trichophyton mentagrophytes ATCC 9533 (MIC=250–500 µg/mL), as found by agar dilution method. The total content of polyphenols (11.66–78.36 mg/g), anthracene derivatives (0.26–12.93 mg/g) and tannins (4.00–11.16%) was also determined.

show abstract

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of the extracts from fruits of Rumex L. species

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Doxorubin hydrochloride was used as a reference compound and was purchased from SIGMA. Individual wells of a 96-well tissue culture microtiter plate (Falcon BD) were inoculated with 100 ml of complete medium containing 8ϫ10 3 leukemia and/or LoVo cells. The plates were incubated at 37°C for 18 h prior to the experiments.…”

Section: Methodsmentioning

confidence: 99%

“…Compounds (3)(4)(5) are known sesquiterpene lactones and were identified as dehydrocostuslactone (3), 21) artremorin (4) 22) and costunolide (5) 13,18) respectively, by comparison of their spectral data with those in the literature.…”

mentioning

confidence: 99%

“…

…”

mentioning

confidence: 99%

See 1 more Smart Citation

Two New Sesquiterpene Lactones from the Leaves of Laurus nobilis

Dall’Acqua

Viola

Giorgetti

et al. 2006

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

Laurus nobilis L. (Lauraceae) is an evergreen tree widespread in the Mediterranean area and Europe, and as a folk medicine, the decoction or tea of bay leaves is often used as a carminative, intestinal and gastric antispasmodic, against diarrhea, for rheumatic pains, in diseases of the respiratory tract, as a cough sedative, to treat asthma and cardiac diseases, [1][2][3] and in cases of dysmenorrhea (pers. comm.). Previous phytochemical investigations have led to the isolation of several classes of secondary metabolites of laurel leaves, particularly sesquiterpene lactones, 4,5) alkaloids, 5,6) monoterpene and germacrane alcohols, 5,7,8) catechin and procyanidine derivatives, 5,9) glycosylated flavonoids, 10) and megastigmane glucosides.11) As well as sesquiterpene lactones, laurenobiolide 12) and costunolide 13) have been identified as the major compounds of L. nobilis. Many of these lactone derivatives have been shown to possess various pharmacological effects, with antimicrobial, 14,15) immunomodulating 16) and cytotoxic activities. 17) Three costunolide and germacranolide derivatives, isolated from L. nobilis, were recently shown to be able to induce apoptotic chromatin condensation in leukemia cells (HL-60), 18,19) indicating their possibility as leads in the development of new classes of antileukemic drugs. For this reason, we considered this plant in our ongoing studies on antiproliferative agents from vegetal sources. Sequential extracts were prepared using solvents in increasing polarity (petroleum ether, chloroform and methanol), and residues were used to perform preliminary cytotoxic tests against two different cell lines. Activity against Jurkart cell line was established in petroleum ether (PEE) and chloroform extracts, with an IC 50 of 9.1 and 10.2 mg/ml respectively. Only PEE was active against LoVo with an IC 50 of 15.1 mg/ml. Fractionation of the extracts led to the isolation of five sesquiterpene lactones, two of which (1, 2) are new natural products.Compound 1 was obtained as colorless needles. The high resolution (HR)-MS [atmospheric pressure ionization-time of flight (API-TOF)] spectrum showed a protonated molecular ion [MϩH] ϩ at m/z 233.1524, corresponding to a molecular formula of C 15 H 20 O 2 . The IR spectrum showed the presence of a g-lactone ring (1765 cm As a part of our ongoing interest in new bioactive compounds from natural sources, we studied Laurus nobilis (Lauraceae). This plant is widespread in the Mediterranean area and is used for medicinal and economic purposes. Chromatographic separations on active extracts led to the isolation of two new sesquiterpene lactones, 5a,9-dimethyl-3-methylene-3,3a,4,5,5a,6,7,8-octahydro-1-oxacyclopenta[c]azulen-2-one (1) and 3b b-chlorodehydrocostuslactone (2). The structures of the new compounds were identified by 1D and 2D NMR experiments, as well as high resolution mass spectrometry. The cytotoxic activity was also evaluated against three different tumor cell lines of human origin.

show abstract

“…They also contain calories, fiber, carbohydrates, proteins and vitamins (Matsuda, 2002;Dadalioglu, 2004). So the laurel increases digestive juices, activates the liver, helps to break down food such as meat, lowers blood cholesterol, regulates menstrual pain, relieves muscle ache, strengthens skin, cleanses urinary tracts, kills germs, strengthens nerves and hair and reduce blood sugar (Loi, 2004).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Study of Laurus Nobilis in Syria

Mansour¹,

Darwish²,

Ismail³

et al. 2018

JCHPS

View full text Add to dashboard Cite

This study was made to recognize the microscopic formation of Lauraus Nobilis leaves, which were collected from different places from Tartous, Syria. And the results showed: fibres and sclereids, oil cells, vessels, stomata and epidermis.Later, six extracts were obtained by using six different solvents: ethanol, methanol, n-hexan, acetic acid, chlorophorm, dichloromethane, these extracts were used for TLC analysis which showed that the L.nobilis contain: limonien, 1,8 cineol, linalool, terpinol.A part of the extracts were used for the chemical tests by using the suitable reagents that resulted the presence of Flavonoids, Alkolids and Tannins .

show abstract

Ethnopharmacology of Ogliastra (Villagrande Strisaili, Sardinia, Italy)

Cited by 10 publications

References 0 publications

Antimicrobial activity of the extracts from fruits of Rumex L. species

Antimicrobial activity of the extracts from fruits of Rumex L. species

Two New Sesquiterpene Lactones from the Leaves of Laurus nobilis

Phytochemical Study of Laurus Nobilis in Syria

Contact Info

Product

Resources

About