Ethnopharmacology, phytochemistry and pharmacology of Tephrosia purpurea

Palbag, Satadru; Dey, Bijay Kr.; Singh, Neeti Rajan

doi:10.1016/s1875-5364(14)60001-7

Cited by 17 publications

(10 citation statements)

References 19 publications

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“…TPU_06 TEPHROSIN 114909 (Duke, 2017) 7. (Palbag, Dey, & Singh, 2014) 53. TPU_53 TEPIRINDOLE 68915 (Palbag et al, 2014) 54.…”

Section: Phytochemical Dataset Preparationmentioning

confidence: 99%

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Deciphering the multi-scale mechanisms ofTephrosia purpureaagainst polycystic ovarian syndrome (PCOS) and its major psychiatric comorbidities: studies from network-pharmacological perspective

Choudhary

Singh

2019

Preprint

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Tephrosia purpurea (T. purpurea), a plant belonging to Fabaceae (pea) family, is a well-known Ayurvedic herb and is commonly known as Sarapunkha in traditional Indian medicinal system. Described as "Sarwa wranvishapaka", i.e. having capability to heal all types of wounds, it is particularly recognized for its usage in splenomegaly. Towards exploring the comprehensive effects of T. purpurea against polycystic ovarian syndrome (PCOS), its phytochemicals were extensively reviewed and their network pharmacology evaluation is carried out in this study. The complex regulatory potential of its 76 phytochemicals (PCs) against PCOS are enquired by developing and analyzing high confidence tripartite networks of protein targets of each phytochemical at both pathway and disease association scales. We also developed a highconfidence human PPI sub-network specific to PCOS, explored its modular architecture and probed the drug-like phytochemicals (DPCs) having multi-module regulatory potential. The proteins belonging to endocrine system were identified as major targets of the PCs. The study reports 30 DPCs based on ADMET and drug-like properties. Multi-targeting and synergistic capacities of the 12 DPCs against 10 protein targets were identified and evaluated using molecular docking and interaction analyses. The study concludes by highlighting a couple of DPCs as potential sources of PCOS regulators.

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“…TPU_06 TEPHROSIN 114909 (Duke, 2017) 7. (Palbag, Dey, & Singh, 2014) 53. TPU_53 TEPIRINDOLE 68915 (Palbag et al, 2014) 54.…”

Section: Phytochemical Dataset Preparationmentioning

confidence: 99%

“…(Palbag, Dey, & Singh, 2014) 53. TPU_53 TEPIRINDOLE 68915 (Palbag et al, 2014) 54. TPU_54 OVALITENONE 627910 (Rao & Raju, 1984) 55.…”

Section: Phytochemical Dataset Preparationmentioning

confidence: 99%

Deciphering the multi-scale mechanisms ofTephrosia purpureaagainst polycystic ovarian syndrome (PCOS) and its major psychiatric comorbidities: studies from network-pharmacological perspective

Choudhary

Singh

2019

Preprint

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“…In current Ayurveda, HCcA is commonly related to the superordinate disease group of the so-called abdominal diseases ( udara roga ). Among eight types of “abdominal diseases” the most serious conditions are considered to be jalodara or yakriddaludara , which can be interpreted as different varieties of HCcA [ 62 ]. These nosological entities are described as having similar symptoms to another form of “abdominal disease” ( plihodara ) characterized by abdominal distention (due to splenomegaly), accompanied by weakness, anorexia, indigestion, constipation, excessive thirst, breathlessness, coughing, vomiting, cachexia, syncope or coma, and visible yellowish or indigo colored veins in the abdominal area [ 63 ].…”

Section: Introductionmentioning

confidence: 99%

A Complex Multiherbal Regimen Based on Ayurveda Medicine for the Management of Hepatic Cirrhosis Complicated by Ascites: Nonrandomized, Uncontrolled, Single Group, Open-Label Observational Clinical Study

Patel

Gupta

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Hepatic cirrhosis is one of the leading causes of death worldwide, especially if complicated by ascites. This chronic condition can be related to the classical disease entity jalodara in Traditional Indian Medicine (Ayurveda). The present paper aims to evaluate the general potential of Ayurvedic therapy for overall clinical outcomes in hepatic cirrhosis complicated by ascites (HCcA). In form of a nonrandomized, uncontrolled, single group, open-label observational clinical study, 56 patients fulfilling standardized diagnostic criteria for HCcA were observed during their treatment at the P. D. Patel Ayurveda Hospital, Nadiad, India. Based on Ayurvedic tradition, a standardized treatment protocol was developed and implemented, consisting of oral administration of single and compound herbal preparations combined with purificatory measures as well as dietary and lifestyle regimens. The outcomes were assessed by measuring liver functions through specific clinical features and laboratory parameters and by evaluating the Child-Pugh prognostic grade score. After 6 weeks of treatment and a follow-up period of 18 weeks, the outcomes showed statistically significant and clinically relevant improvements. Further larger and randomized trials on effectiveness, safety, and quality of the Ayurvedic approach in the treatment of HCcA are warranted to support these preliminary findings.

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“…Tephrosia purpurea (Fabaceae) is an Indian plant traditionally used in Ayurvedic medicine to treat ulcers, leprosy, rheumatism, asthma, and bronchitis . Over the past few years, several reports have confirmed these traditional uses by demonstrating anti-inflammatory, antiulcer, antimicrobial, or hepatoprotective activities of different parts of this species in in vitro and in vivo models . In 1995, a 30% aqueous-ethanol extract produced industrially from T. purpurea seeds was patented for its ability to stimulate the synthesis of β-endorphin by keratinocytes .…”

mentioning

confidence: 99%

“…1 Over the past few years, several reports have confirmed these traditional uses by demonstrating anti-inflammatory, antiulcer, antimicrobial, or hepatoprotective activities of different parts of this species in in vitro and in vivo models. 1 In 1995, a 30% aqueous-ethanol extract produced industrially from T. purpurea seeds was patented for its ability to stimulate the synthesis of β-endorphin by keratinocytes. 2 This extract is still traded on the European market as a natural cosmetic ingredient of lotions.…”

mentioning

confidence: 99%

Exploiting the Complementarity between Dereplication and Computer-Assisted Structure Elucidation for the Chemical Profiling of Natural Cosmetic Ingredients:Tephrosia purpureaas a Case Study

et al. 2015

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The aqueous-ethanolic extract of Tephrosia purpurea seeds is currently exploited in the cosmetic industry as a natural ingredient of skin lotions. The aim of this study was to chemically characterize this ingredient by combining centrifugal partition extraction (CPE) as a fractionation tool with two complementary identification approaches involving dereplication and computer-assisted structure elucidation. Following two rapid fractionations of the crude extract (2 g), seven major compounds namely, caffeic acid, quercetin-3-O-rutinoside, ethyl galactoside, ciceritol, stachyose, saccharose, and citric acid, were unambiguously identified within the CPE-generated simplified mixtures by a recently developed (13)C NMR-based dereplication method. The structures of four additional compounds, patuletin-3-O-rutinoside, kaempferol-3-O-rutinoside, guaiacylglycerol 8-vanillic acid ether, and 2-methyl-2-glucopyranosyloxypropanoic acid, were automatically elucidated by using the Logic for Structure Determination program based on the interpretation of 2D NMR (HSQC, HMBC, and COSY) connectivity data. As more than 80% of the crude extract mass was characterized without need for tedious and labor-intensive multistep purification procedures, the identification tools involved in this work constitute a promising strategy for an efficient and time-saving chemical profiling of natural extracts.

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Ethnopharmacology, phytochemistry and pharmacology of Tephrosia purpurea

Cited by 17 publications

References 19 publications

Deciphering the multi-scale mechanisms ofTephrosia purpureaagainst polycystic ovarian syndrome (PCOS) and its major psychiatric comorbidities: studies from network-pharmacological perspective

Deciphering the multi-scale mechanisms ofTephrosia purpureaagainst polycystic ovarian syndrome (PCOS) and its major psychiatric comorbidities: studies from network-pharmacological perspective

A Complex Multiherbal Regimen Based on Ayurveda Medicine for the Management of Hepatic Cirrhosis Complicated by Ascites: Nonrandomized, Uncontrolled, Single Group, Open-Label Observational Clinical Study

Exploiting the Complementarity between Dereplication and Computer-Assisted Structure Elucidation for the Chemical Profiling of Natural Cosmetic Ingredients:Tephrosia purpureaas a Case Study

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