Ethologically-based animal models of anxiety disorders

Lister, Richard G.

doi:10.1016/0163-7258(90)90021-s

Cited by 698 publications

(134 citation statements)

References 146 publications

Supporting

Mentioning

122

Contrasting

Unclassified

Order By: Relevance

“…These behavioral paradigms take advantage of the innate explanatory behaviors of rodents and natural fears; these tasks include the open field (OF; decreased time spent in the central part of the OF arena), elevated plus maze (EPM; decreased time spent in open arms), and marble burying test (increased duration of burying an object, e.g., glass marbles) as well as the social anxiety test (decreased time spent by pairs of male rats in social interaction; Lister, 1990). The effects of nicotine and nicotinic agents on anxiety-related paradigms are somewhat contradicting (Table 1).…”

Section: Involvement Of Nachrs In Anxiety and Anxiety Disordersmentioning

confidence: 99%

Nicotine Addiction and Psychiatric Disorders

Kutlu

Parikh

Gould

2015

International Review of Neurobiology

View full text Add to dashboard Cite

Even though smoking rates have long been on the decline, nicotine addiction still affects 20% of the US population today. Moreover, nicotine dependence shows high comorbidity with many mental illnesses including, but are not limited to, attention deficit hyperactivity disorder, anxiety disorders, and depression. The reason for the high rates of smoking in patients with mental illnesses may relate to attempts to self-medicate with nicotine. While nicotine may alleviate the symptoms of mental disorders, nicotine abstinence has been shown to worsen the symptoms of these disorders. In this chapter, we review the studies from animal and human research examining the bidirectional relationship between nicotine and attention deficit hyperactivity disorder, anxiety disorders, and depression as well as studies examining the roles of specific subunits of nicotinic acetylcholine receptors (nAChRs) in the interaction between nicotine and these mental illnesses. The results of these studies suggest that activation, desensitization, and upregulation of nAChRs modulate the effects of nicotine on mental illnesses.

show abstract

Section: Involvement Of Nachrs In Anxiety and Anxiety Disordersmentioning

confidence: 99%

Nicotine Addiction and Psychiatric Disorders

Kutlu

Parikh

Gould

2015

International Review of Neurobiology

View full text Add to dashboard Cite

show abstract

“…In humans, melatonin has been studied for possible application in disorders of mood disturbances that were evident in the circadian profile of melatonin in depressed patients [9]. The anxiolytic effects of mela-tonin have been frequently reported in experimental situations such as "the passive avoidance test", "open field test or high cross", which are constructed situations to induce a "state" of anxiety in the both sex of rats [10].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Gonadectomy on Anxiolytic and Antidepressant Effects of Melatonin in Male and Female Wistar Rats: A Possible Implication of Sex Hormones

Zahra¹,

Lagbouri²,

Mesfioui³

et al. 2012

View full text Add to dashboard Cite

The main objective of this study was to analyze the effects of sex, ovariectomy (Ovx) and orchidectomy (Orx) on antidepressant and anxiolytic effect of melatonin in forced swimming test, open field test and elevated plus maze test. Initially, 4 mg/kg of melatonin was daily administered, at 4:00 pm, to intact male and female rats during 8 weeks. Our results have shown that the effect of chronic injection of Mel is sex dependent in the three behaviors tests. Females rats have responded better than males in behavior test study after administration of melatonin, this difference between the sexes may be related to the action of sex hormones (androgens and estrogens) on behavior in males as well as in females. Secondly, to determine the possible interaction between Melatonin and steroid hormones, Ovx/sham female received Mel at dose of 4 mg/kg alone or NaCl (0.9%) alone, and Orx/sham male received Mel at dose of 4 mg/kg alone or NaCl (0.9%) alone daily and during 8 weeks of treatment at 4:00 pm. All animals were tested in the open-field test, elevated plus maze test for anxiety behavior study, and forced swimming test for depression behavior study. Results revealed that Mel exerts an anxiolytic and antidepressant effects in the orchidectomized males and in intact females, confirming that the suppression of androgens by orchidectomy improved anxiolytic and antidepressant effects of melatonin in males. However in females, the suppression of estrogen by ovariectomy masked the antidepressant and anxiolytic effects of melatonin. Our results confirmed that the antidepressant and anxiolytic effects of melatonin are linked to sex hormones.

show abstract

“…[32] Increase in time spent in the open arm entry parameters are the most representative features of anxiolytic agents. [33] Agent with anxiolytic property decreased anxiety by increasing the open arm exploration. [32] However, 2.5 mg/kg of diazepam caused an increase in the time spent in the open arms of the elevated plus maze which was much higher in comparison to extract treated and normal saline group.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological evaluation of anxiolytic property of aqueous root extract of Cymbopogon citratus in mice

Arome¹,

Chinedu²,

Ameh³

2014

Chron Young Sci

View full text Add to dashboard Cite

Aim: This study was designed to evaluate the anxiolytic property of aqueous root extract of Cymbopogon citratus in mice. Materials and Methods: In this study, stress induced hyperthermia (SIH), elevated plus maze (EPM) and open field experimental models were employed. Results: In SIH model, the extract caused a significant (P < 0.01) reduction in the body temperature (T 2 and ∆T) at doses of 400 mg/kg and 600 mg/kg. Similar reduction in the body temperature was obtained by diazepam 2.5 mg/kg used as standard, while increase in the body temperature (T 2 ) was observed in the normal saline group. In EPM model, experimental doses of 200, 400 mg/kg of the extract and 2.5 mg/kg of diazepam produced significant (P < 0.05) increase in time spent in the open arms when compared to the normal saline group. However, extract dose of 600 mg/kg had no significant (P > 0.05) effect. In open field model, 200 mg/kg and 600 mg/kg extract doses significantly (P < 0.05) increased locomotion of the mice more than the standard, while rearing and defecation were less in the extract groups. Conclusion: In different experimental models used significant anxiolytic effect was observed of the aqueous extract at different dose levels in comparison to reference standard and normal saline group. This clearly justified its folkloric application in the treatment of anxiety disorders.

show abstract

Ethologically-based animal models of anxiety disorders

Cited by 698 publications

References 146 publications

Nicotine Addiction and Psychiatric Disorders

Nicotine Addiction and Psychiatric Disorders

The Influence of Gonadectomy on Anxiolytic and Antidepressant Effects of Melatonin in Male and Female Wistar Rats: A Possible Implication of Sex Hormones

Pharmacological evaluation of anxiolytic property of aqueous root extract of Cymbopogon citratus in mice

Contact Info

Product

Resources

About