Ethosomal Curcumin Promoted Wound Healing and Reduced Bacterial Flora in Second Degree Burn in Rat

Abstract

Curcumin is well known in biomedical investigations with an extensive antimicrobial properties and wound repair effect. However, clinical criteria recommend curcumin should be formulated for topical medication. In this study, we prepared Ethosomal curcumin (Etho-cur) formulation for wound healing and bacterial flora assessments in treated rats which were subjected to second degree burn under a standard procedure. Applying once daily of Etho-cur (0.2%) topically on rat's dorsal for 14 days significantly recovered main aspects of wound repair including re-epithelization (P<0.01), neovascularization (P<0.01), collagen synthesis (P<0.001), granulation tissue formation (P<0.001) compared with control. Considerable wound contraction was occurred by Etho-cur treatment sooner than other groups and after 16 days it was completed with a significant (P<0.001) value. Furthermore, ethosomal formulation of curcumin similar to silver sulfadiazine (SSD) cream 1% potentially inhibited (P<0.001) growth of the burn bacterial flora including as predominant bacteria among experimental isolations during 14 days treatment. Also, antibacterial activity of Etho-cur was estimated approximately 11% more potent than free curcumin in reduction of the burn bacterial flora. Regarding the results, ethosomal curcumin efficiently fights against wound infection and promotes wound repair in burn injuries in rats.

Effects of Curcumin on Vessel Formation Insight into the Pro- and Antiangiogenesis of Curcumin

“…Expect for curcumin itself, ethosomal curcumin also showed the effect of promoting neovascularization in the second degree burns in rat [91] and curcumin cross-linked collagen aerogels also possesses proangiogenesis efficacy [92]. Oil of Curcuma longa also showed significant proangiogenesis activity [93].…”

Evaluation of the potential of nanoparticles containing active substances in selected chronic diseases

“…In addition, this formulation significantly inhibited the growth of the burn bacterial flora, including Pseudomonas aeruginosa. 108 In turn, Li et al 109 manufactured flexible nanoliposomes with daptomycin (DAP-FL) for topical delivery and bacteriostatic activity towards skin infections. The authors used lecithin and sodium cholate in a ratio of 17:1 (w/w) while lipid to drug ratio was 14:1 (w/w).…”

Beneficial Effects of Liposome Containing Arthrocen (ROCEN)) on Atopic Dermatitis in Mice

“…However, because of the very low water solubility of Arthrocen, the use of pharmaceutical carriers such as liposomes is recommended for effective skin delivery of lipophilic molecules of ASU [14][15][16]. Liposome carriers not only are versatile tools in drug delivery but also have anti-oxidative, anti-inflammatory, and wound repair properties [17][18][19].…”