Ethyl 3-[4,5-dimethoxy-2-(5-methyl-2-pyridylsulfamoyl)phenyl]propionate

Ethyl 3-[4,5-dimethoxy-2-(3-methyl-2-pyridylsulphamoyl)phenyl]propionate, C19H24N2O6S

“…The ester group, C(13), C(14), O(3), O(4), C(15), is almost planar [max. deviation from the plane 0.032 (5)A] with dimensions similar to other observations (Hamodrakas et al, 1978;Eliopoulos, Sheldrick & Hamodrakas, 1983). A major difference is in the value of the torsion angle C (14) -997 (7) 3252 (5) 3356 (4) 474 C(4) -330 (7) 4077 (5) 2542 (4) 480 C (5) 289 (6) 3569 (5) 1636 (4) 478 C (6) 204 (6) 2230 (5) 1534 (4) 1.334 (6) C(3)-C(4) 1.388 (7) N(2)-C(7)…”

“…1.363 (6) C(4)--C(5) 1.385 (7) N(2)-C (11) 1.369 (7) C(5)-C(6) 1.378 (7) O(3)-C (14) 1.193 (7) C(7)--C(8) 1.442 (7) O(4)-C (14) 1.330 (7) C (8) (8) 63.5 (6)°], although the value of the torsion angle C(1)-C(2)-C(12)-C(13) is 161.4 (5) °, in disagreement with the other two similar structures (Hamodrakas et al, 1978;Eliopoulos et al, 1983). The high temperature factor of C (16) the methoxy groups to be coplanar with the phenyl ring has resulted in some close contacts between C(17) and C(3), and C (18) (Cruickshank, 1961), while the S(1)-C(1) and S(1)-N(I) bond lengths of 1.777 (5) and 1.589 (4)A are very close to values obtained for similar structures (Hamodrakas et al, 1978).…”

“…Crystallographic studies of a series of these compounds are being carried out Hamodrakas, Filippakis & Sheldrick, 1977;Hamodrakas, Akrigg, Sheldrick & Camoutsis, 1978;Perdikatsis, Catsoulakos & Filippakis, 1979;Panagiotopoulos & Filippakis, 1980;Panagiotopoulos, Filippakis & Catsoulakos, 1980) in attempts to relate structure and activity. The title compound is a member of this series.…”

4,5-Dimethoxy-2-[3-(1,4-oxazinan-4-yl)-3-oxopropyl]-N-(2-pyridyl)benzenesulfonamide methanol solvate

“…The methoxy groups O(5)---C(19) and O(6)--C(20) are almost coplanar with the phenyl ring [torsion angles 4.4 (5) and 2-9 (5) ° respectively] with C(19) and C (20) being 0.07 (1) and 0.14 (1)A from the plane of the ring. This planar arrangement has been observed in more than 70 structures while the O(5)---C(4) and O(6)--C(5) bond lengths, 1-364 (5) and 1.364 (5) A respectively, indicate partial double-bond character and compare well with the average calculated value of 1.36 A for similar bonds (Hamodrakas, 1974). The tendency of the methoxy groups to be coplanar with the phenyl ring has resulted in some close contacts between C(19) and C(3), and C(20) and C(6) and the H atoms attached to them, which have been relieved by an increase of the angles C(3)--C(4)--0(5) and C(6)---C(5)--O(6) from 120 to 125.2 (4) and 125.0 (4) ° respectively.…”

“…Crystallographic studies of a series of these compounds have been carried out (Hamodrakas & ring; torsion angles C(1)---C(2)--C(12)--C(13) = -103.1 (4) and C(2)--C(12)--C(13)--C(14) = 179.9 (3) ° , similar to those of related structures (Hamodrakas et al, 1978;Eliopoulos et al, 1983a,b). The oxazine ring is in the chair conformation.…”