Ethyl 4-anilino-2,6-bis(4-fluorophenyl)-1-phenyl-1,2,5,6-tetrahydropyridine-3-carboxylate

Abstract

Key indicators: single-crystal X-ray study; T = 293 K; mean (C-C) = 0.004 Å; R factor = 0.056; wR factor = 0.167; data-to-parameter ratio = 16.0.In the title compound, C 32 H 28 F 2 N 2 O 2 , the tetrahydropyridine ring adopts a distorted boat conformation. The two fluorophenyl groups are attached to the tetrahydropyridine ring in a trans orientation. The dihedral angle between the planes of the fluoro-substituted rings is 57.0 (1). The amino group and carbonyl O atom are involved in intramolecular hydrogen bonding. In the crystal, weak C-HÁ Á ÁO, C-HÁ Á ÁF and C-HÁ Á Á interactions link the molecules into columns along [010]. Related literature

Methyl 4-(4-fluoroanilino)-1,2,6-tris(4-fluorophenyl)-1,2,5,6-tetrahydropyridine-3-carboxylate

“…The molecular structure of the title compound is illustrated in Fig.1. The bond lengths and angles of the title compound are normal and correspond to those observed in related structures (Khan et al, 2010;Anthal et al, 2013). In the title molecule, tetrahydropyridine ring adopts a distorted boat conformation with asymmetry parameters [ΔC s (C2)=10.10] and [ΔC s (C3-C4)=15.48] (Duax et al, 1975)…”

“…For general background to functionalized piperidines, see: Kamei et al (2005). For related structures, see: Sambyal et al (2011); Brahmachari & Das (2012); Khan et al (2010); Anthal et al (2013). For asymmetry parameters, see: Duax et al (1975).…”

Epidemiological Study of Multidrug Resistant and Efficiency of Piperidine Compounds against Hospital Acquired Opportunistic Pathogens in Tamil Nadu, India

“…In this context, piperidine compounds can also be used as a potential alternative therapeutical compound. Piperidine scaffold has shown a decisive role in several pharmaceutical drugs that are presently existing 21,22 . Piperidine derivatives are isolated from plants and are also synthesized using one or more of their various chemical reactions that have been recognized for the synthesis of piperidine derivatives 22,23 .…”

“…Piperidine scaffold has shown a decisive role in several pharmaceutical drugs that are presently existing 21,22 . Piperidine derivatives are isolated from plants and are also synthesized using one or more of their various chemical reactions that have been recognized for the synthesis of piperidine derivatives 22,23 . Piperidine compounds not only significantly reducing bacterial invasion but also exhibit an attenuated pro-inflammatory response in host-bacteria interactions 24 .…”

“…Piperidine compounds not only significantly reducing bacterial invasion but also exhibit an attenuated pro-inflammatory response in host-bacteria interactions 24 . There is numerous historical background which supports the effectiveness of piperidine derivatives as a promising antimicrobial agent and exhibits significant minimum inhibitory concentration when compared to standard drugs [21][22][23][24] . Hence, the present study focused on isolating multi-drug nosocomial pathogen and testing the efficiency of piperidine derivatives against them.…”