2020
DOI: 10.1016/j.jtcme.2019.08.006
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Ethyl acetate extract of Ceiba pentandra (L.) Gaertn. reduces methotrexate-induced renal damage in rats via antioxidant, anti-inflammatory, and antiapoptotic actions

Abstract: Methotrexate (MTX) is a chemotherapeutic agent and an immunosuppressant used to treat cancer and autoimmune diseases. However, its use is limited by its multi-organ toxicity, including nephrotoxicity, which is related to MTX-driven oxidative stress. Silencing oxidative stressors is therefore an important strategy in minimizing MTX adverse effects. Medicinal plants rich in phenolic compounds are probable candidates to overcome these oxidants. Herein, C . pen… Show more

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Cited by 19 publications
(15 citation statements)
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References 37 publications
(52 reference statements)
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“…AraCyc https://www.plantcyc.org/typeofpublication/aracyc [175] Cytoscape http://www.cytoscape.org/ [183] IMPaLA http://impala.molgen.mpg.de [184] iPath http://pathways.embl.de/ [185]…”
Section: Database Website (Url Accessed On 29 June 2021) Referencesmentioning
confidence: 99%
“…AraCyc https://www.plantcyc.org/typeofpublication/aracyc [175] Cytoscape http://www.cytoscape.org/ [183] IMPaLA http://impala.molgen.mpg.de [184] iPath http://pathways.embl.de/ [185]…”
Section: Database Website (Url Accessed On 29 June 2021) Referencesmentioning
confidence: 99%
“…However, the ethyl acetate extract of the aerial part of C . pentandra scavenged the DPPH radicals with an IC 50 value of 0.0716 mg/mL [ 184 ]. The aqueous and methanol stem bark extracts of C. pentandra inhibited superoxide (O 2 • − ) (IC 50 values of 51.81 and 34.26 μg/mL), hydrogen peroxide (44.84 and 1.78 μg/mL), and protein oxidation induced by H 2 O 2 (120.60 and 140.40 μg/mL) [ 168 ].…”
Section: Pharmacological Potential Of Bombacoideaementioning
confidence: 99%
“…pentandra upon oral administration at 400 mg/kg dose could inhibit methotrexate (MTX)-initiated apoptotic and inflammatory cascades. The extract could improve the architecture of histopathological changes observed in the renal tissue of MTX-induced nephrotoxic rats [ 184 ].…”
Section: Pharmacological Potential Of Bombacoideaementioning
confidence: 99%
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