Ethyl acetate fraction of Osmanthus fragrans var. aurantiacus and its triterpenoids suppress proliferation and survival of colorectal cancer cells by inhibiting NF-κB and COX2

Han, Sanghee; Lim, Sung-Lyul; Kim, Hail; Choi, Hyunjin; Lee, Min Young; Shim, Sun-Yup; Le, Duc Dat; Ha, In Jin; Lee, Mina; Lee, Seok-Geun

doi:10.1016/j.jep.2023.117362

Journal of Ethnopharmacology

2024

DOI: 10.1016/j.jep.2023.117362

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Ethyl acetate fraction of Osmanthus fragrans var. aurantiacus and its triterpenoids suppress proliferation and survival of colorectal cancer cells by inhibiting NF-κB and COX2

Sanghee Han,

Sung-Lyul Lim,

Hail Kim

et al.

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NF-κB pathway and angiogenesis: insights into colorectal cancer development and therapeutic targets

Bahrami,

Khalaji,

Bahri Najafi

et al. 2024

Eur J Med Res

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Colorectal cancer (CRC) is currently ranked as the third most common type of cancer, contributing significantly to mortality and morbidity worldwide. Epigenetic and genetic changes occurred during CRC progression resulted in the cell proliferation, cancer progression, angiogenesis, and invasion. Angiogenesis is one of the crucial steps during cancer progression required for the delivery of essential nutrients to cancer cells and removes metabolic waste. During angiogenesis, different molecules are secreted from tumoral cells to trigger vascular formation including epidermal growth factor and the vascular endothelial growth factor (VEGF). The production and regulation of the secretion of these molecules are modulated by different subcellular pathways such as NF-κB. NF-κB is involved in regulation of different homeostatic pathways including apoptosis, cell proliferation, inflammation, differentiation, tumor migration, and angiogenesis. Investigation of different aspects of this pathway and its role in angiogenesis could provide a comprehensive overview about the underlying mechanisms and could be used for development of further therapeutic targets. In this review of literature, we comprehensively reviewed the current understanding and potential of NF-κB-related angiogenesis in CRC. Moreover, we explored the treatments that are based on the NF-κB pathway.

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NF-κB pathway and angiogenesis: insights into colorectal cancer development and therapeutic targets

Bahrami,

Khalaji,

Bahri Najafi

et al. 2024

Eur J Med Res

View full text Add to dashboard Cite

show abstract

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Ethyl acetate fraction of Osmanthus fragrans var. aurantiacus and its triterpenoids suppress proliferation and survival of colorectal cancer cells by inhibiting NF-κB and COX2

Cited by 1 publication

References 31 publications

NF-κB pathway and angiogenesis: insights into colorectal cancer development and therapeutic targets

NF-κB pathway and angiogenesis: insights into colorectal cancer development and therapeutic targets

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