Ethyl gallate ameliorates diabetes-induced Alzheimer's disease-like phenotype in rats via activation of α7 nicotinic receptors and mitigation of oxidative stress

Nagori, Kushagra; Pradhan, Madhulika; Nakhate, Kartik T.

doi:10.1016/j.bbrc.2024.150925

Biochemical and Biophysical Research Communications

2024

DOI: 10.1016/j.bbrc.2024.150925

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Ethyl gallate ameliorates diabetes-induced Alzheimer's disease-like phenotype in rats via activation of α7 nicotinic receptors and mitigation of oxidative stress

Kushagra Nagori,

Madhulika Pradhan,

Kartik T. Nakhate

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2024

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Chemical Characterization and Assessment of the Neuroprotective Potential of Euphrasia officinalis

Ververis,

Kyriakou,

Paraskeva

et al. 2024

IJMS

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Euphrasia officinalis L., commonly known as eyebright, is a medicinal plant used in folk medicine for eye disorders and memory loss. Due to its abundance of compounds with proven neuroprotective properties, there has been growing interest in exploring eyebright’s potential health benefits, particularly for preventing or treating neurodegenerative diseases like Alzheimer’s disease. Here, seven distinct extracts were generated using solvents of different polarities, consecutively, from plants grown in Greece. The extracts were chemically characterized and assessed for their antioxidant, anticholinesterase, and anti-neurotoxic potentials. Our findings demonstrated eyebright’s notable antioxidant capacity with five extracts exhibiting significant anti-neurotoxic properties by enhancing cell viability by 17.5 to 22.6% in human neuroblastoma cells exposed to neurotoxic amyloid-beta peptides. The ethyl acetate and butanolic extracts were the most effective across all assays, likely due to their high concentrations of active compounds. Therefore, eyebright may be harnessed for developing functional foods, supplements, and pharmaceuticals with potential benefits against Alzheimer’s disease. This study marks the first identification of neuroprotective properties in a Euphrasia species, highlighting its broader therapeutic potential and paving the way for further research.

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Chemical Characterization and Assessment of the Neuroprotective Potential of Euphrasia officinalis

Ververis,

Kyriakou,

Paraskeva

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

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Ethyl gallate ameliorates diabetes-induced Alzheimer's disease-like phenotype in rats via activation of α7 nicotinic receptors and mitigation of oxidative stress

Cited by 1 publication

References 83 publications

Chemical Characterization and Assessment of the Neuroprotective Potential of Euphrasia officinalis

Chemical Characterization and Assessment of the Neuroprotective Potential of Euphrasia officinalis

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