Ethyl Glucuronide in Alcoholic Beverages

Abstract

Wine is an external source of EtG. It has been shown that milligram amounts of the biomarker can be contained in a bottle of wine. This should be considered in biomarker testing, especially in EtG hair analysis, which is susceptible to external contamination.

New biochemical markers of ethyl alcohol abuse – new possibilities in clinical practice

“…Śladowe ilości EtG występują naturalnie w winie, przez co możliwe jest zanieczyszczenie zewnętrzne próbki poddawanych analizie włosów. Może to skutkować wątpliwościami diagnostycznymi [40].…”

Validation of serotonin transporter mRNA as a quantitative biomarker of heavy drinking and its comparison to ethyl glucuronide/ethyl sulfate: A randomized, double‐blind, crossover trial

“…Currently available biomarkers have several drawbacks (Seneviratne & Johnson, 2012); for example, commonly used biological markers (biomarkers), ethyl glucuronide (EtG) and ethyl sulfate (EtS), are better predictors of alcohol exposure and reported to be less informative of quantity or patterns of drinking (Helander et al, 2009; Mastrovito & Strathmann, 2020). Some studies report elevated EtG and/or EtS levels following consumption of non‐alcoholic beverages such as non‐alcoholic beer and wine (Hoiseth et al, 2010; Thierauf et al, 2010) or incidental exposures to alcohol in hand sanitizers or cosmetic hair products (Muller & Iwersen‐Bergmann, 2018; Reisfield et al, 2011), questioning their utility for predicting abstinence. Hence, the development of objective biomarkers to supplement self‐report promises a more effective strategy to assess acute or recent drinking (Howlett et al, 2018; Papas et al, 2016).…”