Ethyl lauroyl arginate-based hydrophobic ion pair complex in lipid nanocapsules: A novel oral delivery approach of rosmarinic acid for enhanced permeability and bioavailability

Gad, Heba A.; Ishak, Rania A.H.; Labib, Rola M.; Kamel, Amany O.

doi:10.1016/j.ijpharm.2022.122388

Cited by 7 publications

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Drug Delivery Systems

Azagury,

Kaeek,

Khoury

et al. 2023

Kirk-Othmer Encyclopedia of Chemical Technology

View full text Add to dashboard Cite

Drug delivery systems (DDSs) and their administration routes play a critical role in the efficacy and safety of drugs. There are several physiological routes for drug delivery, including oral administration, injectables, inhalation, transdermal, intranasal, and transdermal delivery. This article focuses on these administration routes, describes their advantages and disadvantages, and elaborates on triggered and targeted DDS. Additionally, this article also describes drug release mechanisms from DDSs. DDSs are classified based on their physicochemical properties and administration routes. Pulsatile/stimuli systems allow controlled drug release at a specific time or location in response to an external stimulus. In addition, the controlled DDS employs several drug release mechanisms, such as diffusion, swelling, and erosion, to achieve the desired therapeutic effect. Representative applications of DDSs include the treatment of cancer, diabetes, and cardiovascular diseases. The COVID‐19 vaccine is a significant achievement in DDS, showcasing its potential to address global health crises. It utilizes lipid nanoparticles to encapsulate and protect mRNA, enabling targeted delivery to host cells. The mRNA instructs cells to produce the spike protein of the SARS‐CoV‐2 virus, triggering an immune response for COVID‐19 protection. In conclusion, DDSs and their administration routes are vital for safe and effective drug development, with recent advances such as pulsatile/stimuli systems showing promise for targeted delivery. The COVID‐19 vaccine development demonstrates the potential of DDS in tackling global health issues.

show abstract

Drug Delivery Systems

Azagury,

Kaeek,

Khoury

et al. 2023

Kirk-Othmer Encyclopedia of Chemical Technology

View full text Add to dashboard Cite

show abstract

Design of self-emulsifying oral delivery systems for semaglutide: reverse micelles versus hydrophobic ion pairs

Sandmeier,

Ricci,

et al. 2024

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

It was the aim of this study to evaluate the potential of reverse micelles (RM) and hydrophobic ion pairs (HIP) for incorporation of semaglutide into self-emulsifying oral drug delivery systems. Reverse micelles loaded with semaglutide were formed with a cationic (ethyl lauroyl arginate, ELA) and an anionic surfactant (docusate, DOC), whereas HIP were formed between semaglutide and ELA. Maximum solubility of the peptide and the rate of dissolution was evaluated in various lipophilic phases (glycerol monocaprylocaprate:caprylic acid 1:4 (m/m), glycerol monolinoleate:caprylic acid 1:4 (m/m) and glycerol monocaprylocaprate:glycerol monolinoleate 1:4 (m/m)). Self-emulsifying drug delivery systems (SEDDS) loaded with RM and HIP were characterized regarding size distribution, zeta potential, cytocompatibility and Caco-2 permeability. Droplet sizes between 50 and 300 nm with polydispersity index (PDI) around 0.3 and zeta potentials between − 45 mV (RMDOC) and 36 mV (RMELA) were obtained. RM provided an almost 2-fold higher lipophilicity of semaglutide than HIP resulting in a 4.2-fold higher payload of SEDDS compared to HIP. SEDDS containing RM or HIP showed high cytocompatibilities with a cell survival above 75% for concentrations up to 0.1% on Caco-2 cells and acceptable hemolytic activity. Permeation studies across Caco-2 monolayer revealed an at least 2-fold increase in permeability of semaglutide for the developed formulations.

show abstract

Unlocking the potential of Rosmarinic acid: A Review on Extraction, Isolation, Quantification, Pharmacokinetics and Pharmacology

Harindranath,

Susil,

et al. 2024

Phytomedicine Plus

View full text Add to dashboard Cite

Ethyl lauroyl arginate-based hydrophobic ion pair complex in lipid nanocapsules: A novel oral delivery approach of rosmarinic acid for enhanced permeability and bioavailability

Cited by 7 publications

References 45 publications

Drug Delivery Systems

Drug Delivery Systems

Design of self-emulsifying oral delivery systems for semaglutide: reverse micelles versus hydrophobic ion pairs

Unlocking the potential of Rosmarinic acid: A Review on Extraction, Isolation, Quantification, Pharmacokinetics and Pharmacology

Contact Info

Product

Resources

About