Ethylcellulose nanoparticles prepared from nano-emulsion templates as new folate binding haemocompatible platforms

Leitner, S.; Solans, Conxita; García-Celma, María José; Morral-Ruíz, Genoveva; Melgar-Lesmes, Pedro; Calderó, Gabriela

doi:10.1016/j.msec.2020.111682

Cited by 9 publications

(4 citation statements)

References 43 publications

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“…The surface charge of these nanoparticles can be adjusted to be either positive or negative, allowing for optimal interaction with the desired genetic biomacromolecule. This versatility makes ethylcellulose nano-emulsions an attractive candidate for gene delivery in various applications [125].…”

Section: Ethylcellulose Nano-emulsionsmentioning

confidence: 99%

Current State of Human Gene Therapy: Approved Products and Vectors

Shchaslyvyi,

Antonenko,

Tesliuk

et al. 2023

Pharmaceuticals

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In the realm of gene therapy, a pivotal moment arrived with Paul Berg’s groundbreaking identification of the first recombinant DNA in 1972. This achievement set the stage for future breakthroughs. Conditions once considered undefeatable, like melanoma, pancreatic cancer, and a host of other ailments, are now being addressed at their root cause—the genetic level. Presently, the gene therapy landscape stands adorned with 22 approved in vivo and ex vivo products, including IMLYGIC, LUXTURNA, Zolgensma, Spinraza, Patisiran, and many more. In this comprehensive exploration, we delve into a rich assortment of 16 drugs, from siRNA, miRNA, and CRISPR/Cas9 to DNA aptamers and TRAIL/APO2L, as well as 46 carriers, from AAV, AdV, LNPs, and exosomes to naked mRNA, sonoporation, and magnetofection. The article also discusses the advantages and disadvantages of each product and vector type, as well as the current challenges faced in the practical use of gene therapy and its future potential.

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Section: Ethylcellulose Nano-emulsionsmentioning

confidence: 99%

Current State of Human Gene Therapy: Approved Products and Vectors

Shchaslyvyi,

Antonenko,

Tesliuk

et al. 2023

Pharmaceuticals

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“…A mixture of ricinoleamidopropyltrimonium methosulfate and Kolliphor ® EL (ethoxylated castor oil) was also used to prepare O/W nanoemulsions with HEPES buffer solution as continuous phase and a 6 wt % solution of ethylcelullose in ethyl acetate as the dispersed phase [ 47 ]. Nanoemulsions formed at O/S ratios between 45/55 and 90/10, above 35 wt % HEPES solution content.…”

Section: Reviewmentioning

confidence: 99%

“…When water was replaced with PBS (0.16 M) for the PIC preparation of nanoemulsions starting from ricinoleamidopropyltrimonium methosulfate + Kolliphor ® EL + 6 wt % ethyl cellulose in ethyl acetate, an increase in the area of the nanoemulsion region in the phase diagram was observed [ 47 ]. The average nanoparticle size also slightly decreased (from 45 to 40 nm) when water was replaced by HEPES solution as the aqueous phase in the nanoemulsion.…”

Section: Reviewmentioning

confidence: 99%

Polymer nanoparticles from low-energy nanoemulsions for biomedical applications

Grijalvo¹,

Rodríguez‐Abreu²

2023

Beilstein J. Nanotechnol.

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The formulation of nanoemulsions by low-energy strategies, particularly by the phase inversion composition method, and the use of these nanoemulsions as templates for the preparation of polymer nanoparticles for biomedical applications are reviewed. The methods of preparation, nature of the components in the formulation, and their impact on the physicochemical properties, drug loading, and drug release are discussed. We highlight the utilization of ethyl cellulose, poly(lactic-co-glycolic acid), and polyurethane/polyurea in the field of nanomedicine as potential drug delivery systems. Advances are still needed to achieve better control over size distribution, nanoparticle concentration, surface functionalization, and the type of polymers that can be processed.

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“…66,72,75,76 However, several methods for modifying magnetic iron nanoparticles have been developed to improve the carriers for unrestricted use and with maximum efficiency. 66,70,72,74,[77][78][79][80][81] Polymeric molecules such as polyethene glycol (PEG) 82,83 polyvinylpyrrolione (PVP), [84][85][86] poly (lactic-co-glycolic acid) (PLGA) [87][88][89] and polyvinyl alcohol (PVA) [87][88][89] have been used as coatings for these nanoparticles, mainly enhancing various chemical and physical properties 75,[90][91][92][93] In addition, the surface coating is made of natural and oen abundant organic molecules such as chitosan, chitin, ethyl cellulose, gelatin, starch, (3aminopropyl) trietoxylesan (APTES), carboxymethyldextrana among others [94][95][96][97][98][99][100][101][102][103] has been used. Therefore, chemical modi-ers increase the versatility of these supports, allowing the immobilization of various biologically active and complex molecules.…”

Section: Introductionmentioning

confidence: 99%