1992
DOI: 10.1016/0165-7992(92)90085-v
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Ethylene dibromide: negative results with the mouse dominant lethal assay and the electrophoretic specific-locus test

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Cited by 5 publications
(2 citation statements)
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“…DBE failed to induce chromosome aberrations or micronuclei in the mouse bone marrow 1,9,11,21) . No induction of dominant lethal mutation by this chemical was detected in mice 12,13) and in rats 11) . Because, in the present study, DNA was isolated from whole testis and germ cells were not separated from supporting tissues, lacZ mutations scored in the testis DNA may also contain mutations in the somatic tissue that are not inherited to next generation.…”
Section: Discussionmentioning
confidence: 99%
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“…DBE failed to induce chromosome aberrations or micronuclei in the mouse bone marrow 1,9,11,21) . No induction of dominant lethal mutation by this chemical was detected in mice 12,13) and in rats 11) . Because, in the present study, DNA was isolated from whole testis and germ cells were not separated from supporting tissues, lacZ mutations scored in the testis DNA may also contain mutations in the somatic tissue that are not inherited to next generation.…”
Section: Discussionmentioning
confidence: 99%
“…DBE is a direct acting mutagen in bacteria and mammalian cells in culture 8) . However, no increase of chromosome aberration and micronucleus in the bone marrow 9,10) nor of dominant lethal has been detected in rats 11) and mice 12,13) after administration of DBE. Carbon tetrachloride induced liver tumors in the mouse, rat and hamster following the exposure by different routes, including inhalation and oral administration, and is classified in Group N HACHIYA et al…”
Section: Introductionmentioning
confidence: 99%