Ethylene glycol poisoning may be associated with elevated post-mortem vitreous glucose level

Kriikku, Pirkko; Ojanperä, Ilkka; Lunetta, Philippe

doi:10.1016/j.legalmed.2023.102279

Cited by 1 publication

(1 citation statement)

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“…EG is metabolized in the body through a series of enzymatic reactions, ultimately forming toxic metabolites. These metabolites can cause damage to various organs, particularly the kidneys, central nervous system, and heart 1 …”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantification of seven glycols in antifreeze liquids using direct liquid injection gas chromatography coupled with mass spectrometry

Danila,

Cretu,

Puscasu

2023

Rapid Comm Mass Spectrometry

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Glycol‐based antifreeze liquids, commonly composed of ethylene glycol or propylene glycol, have important uses in automotive cooling, but they should be handled with care due to their toxicity. Ethylene glycol is highly toxic to humans and animals. A fast, accurate, precise, and robust method was developed for the simultaneous quantification of seven most important glycols and their isomers.MethodsGlycols were analyzed from diluted sample solution of coolants using gas chromatography coupled with mass spectrometry (GC–MC) in single ion monitoring mode.ResultsThe method was developed and validated for seven individual glycols (ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, propylene glycol, dipropylene glycol, and tripropylene glycol). Limits of detection (1–2 μg/mL) and limits of quantification (10 μg/mL) obtained were appropriate. The present method was applied for the determination of glycols in 10 different antifreeze liquids commercially available on the Romanian market, proving to be reliable.ConclusionsA method that requires only a two‐step dilution of antifreeze samples combined with direct liquid injection GC–MS was validated for the simultaneous quantification of seven glycols (and their isomers) in 10 different types of antifreeze liquids. The results obtained in the validation procedure proved that the GC–MS method is sensitive and precise for the quantification of glycols.

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Section: Introductionmentioning

confidence: 99%