Ethylene Maleic Anhydride Copolymers as Viral Inhibitors

Influence of divinyl ether-maleic anhydride (pyran) on foot-and-mouth disease virus infection: Effect on adsorption and multiplication in mouse tissues

“…In exploring the mechanism of protection afforded by pyran against FMDV infection, one must consider the possibility of direct antiviral activity, particularly since other viruses are inactivated by direct association with pyran (6,9,14). It has been shown, for example, that simulatneous intraperitoneal injections of pyran and F3/II)V in mice resulted in a significant degree of protection (20).…”

“…Evidence has been presented for the binding of ethelene maleic anhydride polymers to cells (9) which suggests that adsorption to or release of virus from treated cells might be blocked. As shown in Table 2, however, this apparently is not the case with FMDV since minced spleen, heart, skeletal muscle, kidney, and liver from pyran-treated mice adsorbed virus to about the same extent as tissues from control animals.…”

Studies of miscibility and specific interactions of antitumor-active anhydride copolymer and poly(ethylene glycol) blends

“…The development of various hydrophilic materials based on blends and interpolymer complexes of poly(carboxylic acid)s and nonionic water-soluble polymers, which can be defined as drug polymers (Spridon et al 1997), is of great importance, because of their unique properties and possible applications in medicine. Several synthetic polyanions have become objects of interest to investigators for comparison of their physiological properties with those of naturally occurring polyanions (Feltz andRegelson 1962, Markovsky et al 2014) such as poly(acrylic acid), poly(methacrylic acid), poly(ethylene-comaleic anhydride), and oxidized polysaccharides (Regelson 1967, Tong andCheng 2007). Subsequently, the copolymer of divinyl ether and maleic anhydride has also shown significant antitumor activity (Ottenbrite 1982).…”

Polymers Fight HIV: Potent (Pro)Drugs Identified Through Parallel Automated Synthesis

“…The origin of polymers as antiviral agents goes back to the 1960s . Developments in this field well preceded the advent of polymer therapeutics (that is, conjugation of drugs to polymers) and controlled radical polymerization techniques, specifically reversible addition–fragmentation chain transfer (RAFT) polymerization .…”