Ethylene oxide [MAK Value Documentation, 1993]

doi:10.1002/3527600418.mb7521e0005

The MAK‐Collection for Occupational Health and Safety 2012

DOI: 10.1002/3527600418.mb7521e0005

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Ethylene oxide [MAK Value Documentation, 1993]

Abstract: Published in the series Occupational Toxicants , Vol. 5 (1993) The article contains sections titled: Toxic Effects and Modes of Action Metabolism Effects in Man Effects on Animals Acute toxicity Subacute and chronic inhalation toxicity … Show more

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Haemoglobin adducts of ethylene oxide (N‐(2‐hydroxyethyl)valine), propylene oxide (N‐(2‐hydroxypropyl)valine), acrylonitrile (N‐(2‐cyanoethyl)valine), acrylamide (N‐(2‐carbonamide ethyl)valine) and glycidamide (N‐(2‐hydroxy‐2‐carbonamide ethyl)valine) [Biomonitoring Methods, 2015]

Schettgen¹,

Müller²,

Ferstl³

et al. 2016

The MAK‐Collection for Occupational Health and Safety

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The method permits the simultaneous quantification of the N‐terminal haemoglobin adducts N‐(2‐hydroxyethyl)valine (HEV), N‐(2‐hydroxypropyl)valine (HPV), N‐(2‐cyanoethyl)valine (CEV), N‐(2‐carbonamide ethyl)valine (AAV), and N‐(2‐hydroxy‐2‐carbonamide ethyl)valine (GAV) of the carcinogens ethylene oxide, propylene oxide, acrylonitrile, acrylamide, as well as of glycidamide the metabolite of acrylamide in blood. The adducts which are covalently bound to the N‐terminal valine of the globin chain are cleaved off from the globin chain by a modified Edman degradation. The resulting pentafluorophenyl thiohydantoine derivatives of the valine adducts are extracted with diethyl ether, purified and then subjected to tandem mass spectrometric detection. To protect the vicinal hydroxyl group of the glycidamide adduct, the modified Edman degradation is followed by a second derivatization using sulphuric acetone. For calibration, standards are prepared in non‐smoker pooled globin, adding solutions of dipeptide standards simulating the adduct‐bearing latter two N‐terminal amino acids of the haemoglobin chain. They are processed in the same way as the samples to be analyzed. As internal standards, solutions of isolated globin, which has prior been transformed with the deuterated compounds d 3 ‐acrylo‐nitrile, d 3 ‐acrylamide or d 3 ‐propylene oxide, are used. As internal standard for glycidamide, the d 8 ‐labeled, acetonized pentafluorophenyl thiohydantoine of the glycidamide valine adduct is used.

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Haemoglobin adducts of ethylene oxide (N‐(2‐hydroxyethyl)valine), propylene oxide (N‐(2‐hydroxypropyl)valine), acrylonitrile (N‐(2‐cyanoethyl)valine), acrylamide (N‐(2‐carbonamide ethyl)valine) and glycidamide (N‐(2‐hydroxy‐2‐carbonamide ethyl)valine) [Biomonitoring Methods, 2015]

Schettgen¹,

Müller²,

Ferstl³

et al. 2016

The MAK‐Collection for Occupational Health and Safety

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show abstract

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Ethylene oxide [MAK Value Documentation, 1993]

Abstract: Published in the series Occupational Toxicants , Vol. 5 (1993) The article contains sections titled: Toxic Effects and Modes of Action Metabolism Effects in Man Effects on Animals Acute toxicity Subacute and chronic inhalation toxicity … Show more

Cited by 1 publication

References 58 publications

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