Ethylenediaminetetra(methylenephosphonic acid): Genotoxicity, biodistribution, and subchronic and chronic toxicity in rats

Drug Metabolism in Gastrointestinal Tract

“…Environmental insecticide (such as organophosphorus) (Calvin et al, 1988) and naturally occurring pyrethrin (Graham et al, 1970) are also shown to affect the drug metabolism in rodents. Polluted breathing air contains polycyclic aromatic hydrocarbons (PAHs) from cigarette smoke, wood smoke, vehicle exhausts, asphalt roads, or agricultural burn smoke.…”

Feasibility of nSPECT for medical imaging

“…In addition to its use as a bone seeking compound in medical applications, EDTMP is found in various household detergents (45). Daily oral consumption as high as 100 mg/kg/day for 13 weeks in rats demonstrated no adverse affects (46). At a consumption of 500 mg/kg/day, rats showed statistically significant haematological indications of mild anemia (due to iron deficiency) from week 6-13 (46).…”

“…Daily oral consumption as high as 100 mg/kg/day for 13 weeks in rats demonstrated no adverse affects (46). At a consumption of 500 mg/kg/day, rats showed statistically significant haematological indications of mild anemia (due to iron deficiency) from week 6-13 (46). It is suspected that the anemia resulted from the chelation of iron by EDTMP in the digestive system (46).…”

“…At a consumption of 500 mg/kg/day, rats showed statistically significant haematological indications of mild anemia (due to iron deficiency) from week 6-13 (46). It is suspected that the anemia resulted from the chelation of iron by EDTMP in the digestive system (46). Four weeks after the 500 mg/kg/day EDTMP consumption ended, the rats fully recovered from the mild anemia without any intervention in their normal diets (i.e., no nutritional supplements, such as additional iron, were provided) (46).…”

“…It is suspected that the anemia resulted from the chelation of iron by EDTMP in the digestive system (46). Four weeks after the 500 mg/kg/day EDTMP consumption ended, the rats fully recovered from the mild anemia without any intervention in their normal diets (i.e., no nutritional supplements, such as additional iron, were provided) (46). Bone uptake (3.2%)…”