Etilefrine in the Treatment of Levodopa-Induced Orthostatic Hypotension

The Management of Orthostatic Hypotension in Parkinson’s Disease

“…Etilefrine (5–10 mg) was used in 15 PD patients to increase blood pressure upon standing (mean increase of 4.3%) reporting only headaches as adverse outcomes (Miller et al, 1973). …”

Interactions Between Levodopa and Other Drugs

“…Etilefrine hydrocholoride, a sympathomimetic drug which stimulates both a-and~-adrenergic receptors, stabilised the blood pressure in 14 of the 15 patients who developed orthostatic hypotension during levodopa therapy (Miller, 1973). No side-effects or abnormal laboratory findings were encountered.…”

Effect of Selected Drugs on Arterial Pressure Response to Upright Posture

“…In symptomatic orthostatic hypotension, Lund et al [15] reported that in a group of 15 geriatric patients in which tachycardia was associated with orthostatic hyper tension, significant benefit was obtained following the administration of ENP. ENP also appears to be effective in orthostatic hypotension asso ciated withL-dopa administration [18].…”

“…An instance of special interest is the orthostatic hypotension which accom panies administration of L-dopa for Parkinson's disease [3,8,18,31]. The availability of peripheral dopa-decarboxylase inhibitors [21] makes it possible to correct this and other side effects of L-dopa administration while retaining the central effect of therapeutic benefit in Parkinson's disease.…”