Etiologic Factors of the Stevens-Johnson Syndrome

Yetiv, Jack Z.; Bianchine, Joseph R.; Owen, John Andrew

doi:10.1097/00007611-198005000-00015

Cited by 100 publications

(59 citation statements)

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“…Improve ment began 10 days after the onset of the process, and 5 days after admission to hos pital. Patients with EM tend to be young [34,36,37], which is in keeping with the average age of 28 years of the patients in this review. There was no difference in the representa tion of the two sexes evident in this selected sample.…”

supporting

confidence: 63%

Erythema multiforme (Stevens-Johnson Syndrome) – Chart Review of 123 Hospitalized Patients

Nethercott

Choi

1985

Dermatology

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The charts of 123 patients hospitalized with erythema multiforme were reviewed. Antecedent infections and the administration of drugs were associated with 15 and 32% of the cases, respectively. Pyrexia arthralgia, photosensitivity, abnormal liver function tests and abnormal urine sediment were common findings. The length of stay in hospital was 12.6 ± 0.7 days (mean ± SE), time to initial improvement after onset was 10.3 ± 0.6 days and time to complete resolution was 23.0 ± 2.4 days. The presence of bullous skin lesions and greater overall severity were associated with longer hospitalization. Antecedent respiratory tract symptoms were related to shorter hospitalization. Steroid therapy was not associated with a shorter time for initial improvement to occur, while the average length of stay in hospital was 4.2 days longer than that for the patients not treated with corticosteroid.

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supporting

confidence: 63%

Erythema multiforme (Stevens-Johnson Syndrome) – Chart Review of 123 Hospitalized Patients

Nethercott

Choi

1985

Dermatology

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“…These reactions are often associated with inciting drugs and infectious agents. [1][2][3] Although they are rare, with an annual incidence of 1 to 6 cases per million persons, 3,4 these reactions carry high mortality rates of 3% for SJS and 27% for TEN, 5 and surviving patients often experience severe sequelae, such as vision loss caused by severe ocular surface complications. 6 HLA genotypes are associated with SJS/TEN.…”

mentioning

confidence: 99%

IKZF1, a new susceptibility gene for cold medicine–related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement

Ueta

Sawai

Sotozono

et al. 2015

Journal of Allergy and Clinical Immunology

107

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“…We cannot rule out the possibility that an infectious agent that we could not detect may have induced SJS, but the clinical course strongly suggests the antipyretic medicine was the etiologic factor. Yetiv et al reported that an allergic predisposition might have played a role in the development of SJS, and drugs and infections were especially suspect as etiologic agents in SJS (31).…”

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confidence: 99%

Severe Obliterative Bronchitis Associated with Stevens-Johnson Syndrome

et al. 2011

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We report a case of Stevens-Johnson syndrome (SJS) in which the patient had been diagnosed with severe obliterative bronchitis. A 29-year-old woman was admitted with a high fever and a widespread vesicular rash. She was diagnosed with SJS and betamethasone administration was started. After one month, her vesicular skin rash improved; however, she developed respiratory failure and was assisted with mechanical ventilation.Computed tomography of the chest demonstrated a hyperlucent lung with narrowing of the peripheral vessels. Bronchoscopy revealed an occlusion of the bronchus when the patient exhaled. The flow-volume curve revealed a severe obstructive pattern. The patient was diagnosed with obliterative bronchitis following SJS. She was treated with a bronchodilator and steroids, but could not breathe adequately without the ventilator. During the following year, her PaCO2 increased to 100 torr and her heart function also continued to worsen. Despite intensive treatment, she died one year and seven months after the onset of SJS. In SJS and toxic epidermal necrolysis (TEN) patients, chronic pulmonary complications are rare, but there is no effective therapy for obliterative bronchitis following SJS/TEN. Therefore, early awareness of this condition is needed and lung transplantation must be considered at an early stage of this disease.

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Etiologic Factors of the Stevens-Johnson Syndrome

Cited by 100 publications

References 0 publications

Erythema multiforme (Stevens-Johnson Syndrome) – Chart Review of 123 Hospitalized Patients

Erythema multiforme (Stevens-Johnson Syndrome) – Chart Review of 123 Hospitalized Patients

IKZF1, a new susceptibility gene for cold medicine–related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement

Severe Obliterative Bronchitis Associated with Stevens-Johnson Syndrome

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