2022
DOI: 10.21203/rs.3.rs-2356539/v1
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Etiologic fractions in patients of Hepatocellular carcinoma in India with and without a background of cirrhosis - a multi-centric study

Abstract: Background: Hepatocellular cancer (HCC) typically arises in the background of cirrhosis. Its epidemiology has been changing due to availability of antivirals, changing life-styles and early detection. We undertook a multicentric national sentinel surveillance for liver cirrhosis and HCC to assess the attributable risk factors for development of HCC, both with and without a background of cirrhosis. Methods: Data from January 2017 till August 2022 from hospital-based records of eleven participating centres was … Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
5
0

Year Published

2023
2023
2023
2023

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(5 citation statements)
references
References 27 publications
0
5
0
Order By: Relevance
“…A 4-fold increased risk of HCC is reported among persons with elevated levels of aflatoxin B1 and reaches up to 60-fold greater in persons with aflatoxin exposure and viral hepatitis. 18…”
Section: Other Risk Factorsmentioning
confidence: 99%
See 2 more Smart Citations
“…A 4-fold increased risk of HCC is reported among persons with elevated levels of aflatoxin B1 and reaches up to 60-fold greater in persons with aflatoxin exposure and viral hepatitis. 18…”
Section: Other Risk Factorsmentioning
confidence: 99%
“…Among those with HCC, 27.9% (n = 744) had no cirrhosis. Patients with diabetes more commonly had noncirrhotic HCC (50.5 vs. 35.2%) 18 (Table 4). The factors involved in the development of HCC are endogenous hyperinsulinemia (insulin resistance), exogenous hyperinsulinemia (treatment with insulin or secretagogues), hyperglycemia, and/or chronic inflammation.…”
Section: Risk Factors For Hccmentioning
confidence: 99%
See 1 more Smart Citation
“…In the total group, the most frequent causes associated with hepatocellular carcinoma were non-alcoholic fatty liver disease, hepatitis B, hepatitis C and alcoholism, in that order. 5 …”
Section: Introductionmentioning
confidence: 99%
“…
Figure 2 Complications of cirrhosis and progression of compensated cirrhosis to ACLF. 5–11 A compensated cirrhosis has alteration in intestinal biota, permeability, chronic inflammation, and portal hypertension. During the phase of compensated damage, the liver is subjected to numerous acute insults (alcohol, infections, bleeding, medications, etc) which at some point progress to Acute on Chronic Liver Failure (ACLF), organic failure, and high mortality.
…”
Section: Introductionmentioning
confidence: 99%