Etiologic heterogeneity among non-Hodgkin lymphoma subtypes

Morton, Lindsay M.; Wang, Sophia; Cozen, Wendy; Linet, Martha S.; Chatterjee, Nilanjan; Davis, Scott; Severson, Richard K.; Colt, Joanne S.; Vasef, Mohammad A.; Rothman, Nathaniel; Blair, Aaron; Bernstein, Leslie; Cross, Amanda J.; Roos, Anneclaire J. De; Engels, Eric A.; Hein, David W.; Hill, Deirdre A.; Kelemen, Linda E.; Lim, Unhee; Lynch, Charles F.; Schenk, Maryjean; Wacholder, Sholom; Ward, Mary H.; Zahm, Shelia Hoar; Chanock, Stephen J.; Cerhan, James R.; Hartge, Patricia

doi:10.1182/blood-2008-01-133587

Cited by 152 publications

(161 citation statements)

References 65 publications

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“…A recent study in classical HL patients has shown that despite the oncogenic effect of IGF‐IR, a higher expression at diagnosis predicted a favourable outcome both for overall survival and 5‐year progression‐free survival 19. In the current prospective study, the association between IGF‐I and overall lymphoma risk was close to significant; however, we had relatively limited sample size and lymphoma is a heterogeneous disease 20. Therefore, further prospective analyses of the association in studies with information on lymphoma subtype are warranted.…”

Section: Discussionmentioning

confidence: 81%

Prediagnostic circulating concentrations of plasma insulin‐like growth factor‐I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Pérez-Cornago

Appleby

Tipper

et al. 2016

Intl Journal of Cancer

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Insulin‐like growth factor (IGF)‐I has cancer promoting activities. However, the hypothesis that circulating IGF‐I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF‐I concentration was measured in pre‐diagnostic plasma samples from a nested case–control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF‐I concentration was not associated with overall lymphoma risk (multivariable‐adjusted OR for highest versus lowest third = 0.77 [95% CI = 0.57–1.03], p trend = 0.06). There was no statistical evidence of heterogeneity in this association with IGF‐I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (p heterogeneity for all ≥ 0.05). There were no associations between IGF‐I concentration and risk for specific BCL subtypes, T‐cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF‐I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF‐I concentrations and risk of lymphoma. Further prospective data are required to examine associations of IGF‐I concentrations with lymphoma subtypes.

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Section: Discussionmentioning

confidence: 81%

Prediagnostic circulating concentrations of plasma insulin‐like growth factor‐I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Pérez-Cornago

Appleby

Tipper

et al. 2016

Intl Journal of Cancer

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“…Although these data effectively characterize the subtype spectrum of lymphomas [18][19][20][21][22][23][24][26][27][28][29][30][31][32][33][34][35], most studies have excluded the majority of plasma cell neoplasms and leukemias (circulating phase). Therefore, these results may not be comparable with population-based incidence data for the entire spectrum of WHO classifications [10,42,43].…”

Section: Introductionmentioning

confidence: 74%

Distribution of lymphoid neoplasms in the Republic of Korea: Analysis of 5318 cases according to the World Health Organization classification

et al. 2010

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Compared with the West, the overall incidence of lymphoid neoplasms is lower, and the subtype distribution is distinct in Asia. To comprehensively investigate the subtype distribution with the age and sex factors, and temporal changes of subtype proportions, we re-assessed all patients with lymphoid neoplasms diagnosed at a large oncology service in the Republic of Korea from 1989 to 2008 using the World Health Organization classifications. Of the total 5,318 patients, 66.9% had mature B-cell neoplasms, 12.5% had mature T/natural killer (NK)-cell neoplasms, 16.4% had precursor lymphoblastic leukemia/lymphoma (ALL/LBL), and 4.1% had Hodgkin's lymphoma. The most common subtypes were diffuse large B-cell lymphoma (30.5%), plasma cell myeloma (14.0%), extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type (MALT lymphoma; 12.4%), B-cell ALL/LBL (11.3%), Hodgkin's lymphoma (4.1%), peripheral T-cell lymphoma unspecified (4.0%), T-cell ALL/LBL (3.9%), and extranodal NK/T-cell lymphoma of nasal type (3.9%). Most subtypes showed male predominance, with an average M/F ratio of 1.3. Most mature lymphoid neoplasms were diseases of adults (mean age, 53.5 yr), whereas ALL/LBLs were of young individuals (mean age, 20.3 yr). When the relative proportion of subtypes were compared between two decades (1989-1998 vs. 1999-2008), especially MALT lymphoma has increased in proportion, whereas T/NK-cell neoplasms and ALL/LBL have slightly decreased. In summary, the lymphoid neoplasms of Koreans shared some epidemiologic features similar to those of other countries, whereas some subtypes showed distinct features. Although the increase in incidence of lymphoid neoplasms is relatively modest in Korea, recent increase of MALT lymphoma and decrease of T/NK-cell neoplasms and ALL/LBL are interesting findings. Am. J. Hematol. 85:760-764, 2010. V V C 2010 Wiley-Liss, Inc. IntroductionLymphoid neoplasms are a diverse group of neoplasms with different clinical presentations, histology, and biology [1,2]. Recent revolutionary advances in immunology, genetics, and molecular biology have resulted in extensive changes in the classifications of these tumors, culminating in the Revised European-American classification (1994) and its successor, the World Health Organization (WHO) classification (2001 and 2008) [1][2][3]. Both Revised European-American and WHO classifications encompass not only Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL) but also plasma cell neoplasm and lymphoid leukemia, acknowledging that lymphoma and lymphoid leukemia represent solid and circulating phases, respectively, of the same disease [1][2][3]. Lymphoid neoplasms are the sixth most common malignancy worldwide [4,5], but there are marked geographic variations, with the highest rates observed in North America and Australia, followed by Europe, and lower rates throughout Asia [4,5].There are ethnic and regional differences in the distribution of subtypes. For example, populations of Asian countries have higher proportions of mature T/natural k...

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“…30,31 Epidemiologic studies discovered that immunodeficiency increased the probability of NHL. [31][32][33][34] Lymphocytes are mediators of antibody-dependent cell-mediated cytotoxicity 35 and are indicators of host immune activity. 17 Monocytes generate host antitumor immune suppression and play an important part in tumor angiogenesis, which promote cell proliferation and tumor invasion.…”

Section: Discussionmentioning

confidence: 99%

Prognostic impact of absolute lymphocyte count/absolute monocyte count ratio and prognostic score in patients with nasal-type, extranodal natural killer/T-cell lymphoma

Zhang

Song

et al. 2017

Tumour Biol.

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Nasal-type, extranodal natural killer/T-cell lymphoma is a heterogeneous disorder with poor prognosis, requiring risk stratification in this population. The combined value of baseline absolute lymphocyte count and absolute monocyte count provided prognostic information in some malignancies. However, the evidence requires validation in extranodal natural killer/T-cell lymphoma. Aiming to investigate the prognostic significance of absolute lymphocyte count/absolute monocyte count ratio and absolute lymphocyte count/absolute monocyte count prognostic score for extranodal natural killer/Tcell lymphoma, a retrospective research was carried out. A total of 264 patients with newly diagnosed extranodal natural killer/T-cell lymphoma were analyzed in this study. The patients' absolute lymphocyte count and absolute monocyte count tested at initial diagnosis were collected. Receiver operating curve analysis showed that the optimal cut-off values for absolute lymphocyte count and absolute monocyte count were 1.0 × 10 9 and 0.5 × 10 9 L −1 , respectively, and for absolute lymphocyte count/absolute monocyte count ratio was 2.85. After a median follow-up of 27 months (range 1-87 months), the 3-year overall survival and progression-free survival was 75.4% and 67.6%, respectively. Patients with absolute lymphocyte count/absolute monocyte count ratio ≥ 2.85 had better 3-year overall survival and progressionfree survival than those with absolute lymphocyte count/absolute monocyte count ratio <2.85 (p < 0.001). According to absolute lymphocyte count/absolute monocyte count prognostic score, significant difference has been noticed in 3-year overall survival and progression-free survival (p < 0.001) and high absolute lymphocyte count/absolute monocyte count prognostic score was associated with poorer survival. The International Prognostic Index and Korean Prognostic Index were used for prognosis and showed no significant difference. When adding absolute lymphocyte count/absolute monocyte count ratio and absolute lymphocyte count/absolute monocyte count prognostic score to the International Prognostic Index and Korean Prognostic Index model, additional prognostic information was found. These results suggest that absolute lymphocyte count/absolute monocyte count ratio and absolute lymphocyte count/absolute monocyte count prognostic score might be useful prognostic factors in extranodal natural killer/T-cell lymphoma.

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Etiologic heterogeneity among non-Hodgkin lymphoma subtypes

Cited by 152 publications

References 65 publications

Prediagnostic circulating concentrations of plasma insulin‐like growth factor‐I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Prediagnostic circulating concentrations of plasma insulin‐like growth factor‐I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Distribution of lymphoid neoplasms in the Republic of Korea: Analysis of 5318 cases according to the World Health Organization classification

Prognostic impact of absolute lymphocyte count/absolute monocyte count ratio and prognostic score in patients with nasal-type, extranodal natural killer/T-cell lymphoma

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