Etiologic spectrum and pattern of antimicrobial drug susceptibility in bacterial meningitis in Sokoto, Nigeria

Emele, FE

doi:10.1080/080352500750043396

Cited by 13 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only one sample (0.32%) was collected above the age of 70 years. This was similar to the study of Emele [14] where 68% cases were in the age group 1-9 years and this, however contrasted with Mani et al [15] where 86.8% were adults and 13.2% were below the age of 12 years.…”

Section: Discussioncontrasting

confidence: 59%

Study on isolates of acute meningitis in a tertiary care centre in Assam

Gitali¹,

Barkataki²,

Hazarika³

2014

Int J Med Public Health

View full text Add to dashboard Cite

Background: Meningitis is an infl ammatory affection of the membranes surrounding the brain and spinal cord, which occurs as either a primary disease or secondarily to disease in some other part of the body. The epidemiological trend of acute meningitis varies with time and geography. Objective: To isolate the various agents of acute meningitis in all age group patients and to know the antimicrobial susceptibility pattern of bacterial isolates. Materials and Mathods: In this prospective study, a total of 316 cerebrospinal fl uid (CSF) specimens were collected from patients showing signs and symptoms of acute meningitis and processed by standard microbiological methods in a tertiary care hospital in Guwahati, Assam over a period of one year, from August 2009 to July 2010. Results: Out of 316 CSF samples, bacterial and fungal culture positivity rate was found to be 16.13%. The most common bacterial isolate was Staphylococcus aureus, 29.41%. Isolation rate of Cryptococcus neoformans was 8%. All the Gram positive isolates were 100% sensitive to linezolid and vancomycin, whereas Gram negative isolates were 92% sensitive to polymyxin B. Conclusion: This study gives an idea about the changing trend of acute meningitis along with the changing in vitro antimicrobial susceptibility pattern of the bacterial isolates, which can help the clinicians to formulate the initial empiric therapy for patients of acute meningitis. Bhagawati, et al.: Isolates of acute meningitis Abstract

show abstract

Section: Discussioncontrasting

confidence: 59%

Study on isolates of acute meningitis in a tertiary care centre in Assam

Gitali¹,

Barkataki²,

Hazarika³

2014

Int J Med Public Health

View full text Add to dashboard Cite

show abstract

“…[ 12 ] Penicillin non-susceptible rates of 18%, 29.72%, 11.76% and 67% were also reported by different workers from different regions in Nigeria. [ 13 14 15 16 ] The rapid emergence of antibiotic resistance is adding to the burden of pneumococcal disease by significantly contributing to the numbers of treatment failures and deaths from this disease.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial susceptibility pattern of invasive pneumococcal isolates in North West Nigeria

Lliyasu

Habib

Mohammad

2015

J Global Infect Dis

View full text Add to dashboard Cite

Background:An alarming increase in infections due to penicillin non-susceptible pneumococci (PNSP) has been documented in nearly all countries. Increasingly, PNSP are also resistant to other antibiotics, and a growing number of clinical failures following the use of these agents have been reported.Aims:To determine the resistance pattern of pneumococcal isolates from patients with invasive pneumococcal infection in North West Nigeria.Materials and Methods:In a cross-sectional study clinical specimens were obtained from patients with community acquired pneumonia (CAP), meningitis and bacteraemia over a 2 year period. Pneumococcus strains were identified. Isolates were tested against a panel of antibiotics using E-test strips, and interpreted according to the CLSI criteria. 0.06 μg/ml was used as break point for penicillin. Analysis was carried out using descriptive statistics; relationships determined using chi-squared or Fisher's exact tests, with P < 0.05 regarded as significant.Results:Total number of isolates was 132. Twenty-two (16.7%) of the isolates were fully sensitive to penicillin while 73 (55.3%) and 37 (28.0%) were intermediately and fully resistant, respectively. One hundred and twenty-seven (96.2%) of the isolates were fully resistant to trimethoprim–sulphamethoxazole. Eleven (8.5%) were fully resistant to amoxicillin and 104 (78.8%) and 17 (12.9%) were intermediately resistant and fully susceptible. One hundred and six (80.3%) of the isolates were fully susceptible to chloramphenicol. Resistance to penicillin was shown to infer resistance to other antibiotics.Conclusions:Pneumococcal resistance is common in North West Nigeria. Ceftriaxone retains excellent activity against most of the invasive isolate, while trimethoprim-sulphamethoxazole is almost uniformly resistant.

show abstract

“…Listeria monocytogenes accounts for only 0.4% of community-acquired meningitis. 2 However, the majority of these cases occur in newborns, pregnant women, the elderly, and people with compromised immune function. 3 The rarity of L monocytogenes meningitis beyond infancy makes the isolation of the bacteria in our patient’s CSF strongly suspicious of immune dysfunction.…”

Section: Discussionmentioning

confidence: 99%