Etiological classification and manifestation of pulmonary artery dissection: A literature review and case analysis

Zeng, Qi-xian; Xi, Qun-ying; Luo, Qin; Liu, Zhi-hong; Xiong, Chang-ming

doi:10.1016/j.heliyon.2023.e22570

Cited by 2 publications

(1 citation statement)

References 94 publications

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“…In terms of nebulizers, during the process of nebulizing the liposome dispersion into inhalable aerosol droplets, physical shear force may be exerted on the double layer of the liposomes [ 37 , 38 ]. This can result in the initial cargo loss and a reduction in delivery efficiency.…”

Section: Pressurized Metered-dose Inhalers Are Promising For Liposome...mentioning

confidence: 99%

Overcoming the Low-Stability Bottleneck in the Clinical Translation of Liposomal Pressurized Metered-Dose Inhalers: A Shell Stabilization Strategy Inspired by Biomineralization

Huang,

Chang,

Gao

et al. 2024

IJMS

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Currently, several types of inhalable liposomes have been developed. Among them, liposomal pressurized metered-dose inhalers (pMDIs) have gained much attention due to their cost-effectiveness, patient compliance, and accurate dosages. However, the clinical application of liposomal pMDIs has been hindered by the low stability, i.e., the tendency of the aggregation of the liposome lipid bilayer in hydrophobic propellant medium and brittleness under high mechanical forces. Biomineralization is an evolutionary mechanism that organisms use to resist harsh external environments in nature, providing mechanical support and protection effects. Inspired by such a concept, this paper proposes a shell stabilization strategy (SSS) to solve the problem of the low stability of liposomal pMDIs. Depending on the shell material used, the SSS can be classified into biomineralization (biomineralized using calcium, silicon, manganese, titanium, gadolinium, etc.) biomineralization-like (composite with protein), and layer-by-layer (LbL) assembly (multiple shells structured with diverse materials). This work evaluated the potential of this strategy by reviewing studies on the formation of shells deposited on liposomes or similar structures. It also covered useful synthesis strategies and active molecules/functional groups for modification. We aimed to put forward new insights to promote the stability of liposomal pMDIs and shed some light on the clinical translation of relevant products.

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Section: Pressurized Metered-dose Inhalers Are Promising For Liposome...mentioning

confidence: 99%

Overcoming the Low-Stability Bottleneck in the Clinical Translation of Liposomal Pressurized Metered-Dose Inhalers: A Shell Stabilization Strategy Inspired by Biomineralization

Huang,

Chang,

Gao

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Pulmonary artery dissection secondary to ventricular septal defect and pulmonary valve stenosis

Xiao,

Yang,

Xiao

et al. 2024

Echocardiography

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Etiological classification and manifestation of pulmonary artery dissection: A literature review and case analysis

Cited by 2 publications

References 94 publications

Overcoming the Low-Stability Bottleneck in the Clinical Translation of Liposomal Pressurized Metered-Dose Inhalers: A Shell Stabilization Strategy Inspired by Biomineralization

Overcoming the Low-Stability Bottleneck in the Clinical Translation of Liposomal Pressurized Metered-Dose Inhalers: A Shell Stabilization Strategy Inspired by Biomineralization

Pulmonary artery dissection secondary to ventricular septal defect and pulmonary valve stenosis

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