Etiological prevalence of epilepsy and epileptic seizures in hospitalized elderly in a Brazilian tertiary center – Salvador - Brazil

Assis, Telma; Bacellar, Aroldo; Costa, Gersonita; Nascimento, Osvaldo J. M.

doi:10.1590/0004-282x20140217

Cited by 27 publications

(37 citation statements)

References 29 publications

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“…Certain deleterious features, such as regular drug use, vascular malformations, strokes, and tumors can be addressed in an efficient, age‐relevant fashion. Confidence in our results is further augmented by the fact that these features selected a priori based on their presumed clinical relevance (such as stroke, tumors, and features of epilepsy of presumed genetic origin) were indeed found to be age‐specific based on the results of a supervised classification machine‐learning algorithm.…”

Section: Discussionsupporting

confidence: 64%

Towards a clinically informed, data‐driven definition of elderly onset epilepsy

et al. 2015

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SUMMARYObjective: Elderly onset epilepsy represents a distinct subpopulation that has received considerable attention due to the unique features of the disease in this age group. Research into this particular patient group has been limited by a lack of a standardized definition and understanding of the attributes associated with elderly onset epilepsy. Methods: We used a prospective cohort database to examine differences in patients stratified according to age of onset. Linear support vector machine learning incorporating all significant variables was used to predict age of onset according to prespecified thresholds. Sensitivity and specificity were calculated and plotted in receiveroperating characteristic (ROC) space. Feature coefficients achieving an absolute value of 0.25 or greater were graphed by age of onset to define how they vary with time. Results: We identified 2,449 patients, of whom 149 (6%) had an age of seizure onset of 65 or older. Fourteen clinical variables had an absolute predictive value of at least 0.25 at some point over the age of epilepsy-onset spectrum. Area under the curve in ROC space was maximized between ages of onset of 65 and 70. Features identified through machine learning were frequently threshold specific and were similar, but not identical, to those revealed through simple univariable and multivariable comparisons. Significance: This study provides an empirical, clinically informed definition of "elderly onset epilepsy." If validated, an age threshold of 65-70 years can be used for future studies of elderly onset epilepsy and permits targeted interventions according to the patient's age of onset.

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Section: Discussionsupporting

confidence: 64%

Towards a clinically informed, data‐driven definition of elderly onset epilepsy

et al. 2015

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“…The main etiology for the epileptic seizures was structural alteration of the CNS (epilepsies and cancer). A study that described the causal prevalence of epileptic seizures in the elderly showed that epilepsy and epileptic seizures have an etiological association with stroke, cancer, and dementias (9) .…”

Section: Discussionmentioning

confidence: 99%

Inflammatory signs and epileptic crisis in patients admitted in an emergency unit

Guzzo

Pedrini

Breigeiron

2020

Rev. Gaúcha Enferm.

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Objective: To evaluate inflammatory signs presented in medical records of patients with a main diagnosis of epileptic seizures, admitted in an emergency unit. Method: Cross-sectional and retrospective study. The sample was composed of 191 medical records, from children, adolescents, adults, and elders, with a clinical diagnosis of epileptic seizures, admitted between June 2016 and June 2017 at the emergency unit of a hospital in Porto Alegre/RS. Results: The prevalent inflammatory signs were tachypnea (33.5%) and/or fever (27.2%) associated with leukocytosis (P=0.030). Children/adolescents had seizures less frequently (P=0.010) and these were due to fever (P=0.000). Adults presented seizures more frequently (P=0.006), which were related to medication/intoxication (P=0.000). In elders, seizures occurred due to metabolic or circulatory abnormalities (P=0.000), less often due to fever (P=0.005). Conclusion: Seizures are related to fever and tachypnea, being caused by different etiologies according to age, being more frequent in adults. Fever is related to leukocytosis, regardless of age.

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“…Ayrıca olguların %37.2'sinde jeneralize tip nöbet, %24.6'sın-da fokal nöbet görüldüğü bildirilmiştir. [13] Yaşlı epilepsililerde EEG bulguları genellikle nonspesifik olmakla birlikte amplitüd düşüklüğü, fokal yavaş dalga aktivitesi ve fokal epileptik dalga aktivitesi görülebilir. Olgularımı-zın %32'sinde EEG bulguları anormal olarak kaydedilmekle birlikte en sık görülen anormallik lezyon yeri ile uyumsuz yaygın zemin ritim düzensizlikleri idi.…”

Section: Discussionunclassified

“…Daha önceden yapılmış geriye dönük bir çalışmada 120 olgu geriye dö-nük olarak değerlendirilmiş, etiyolojik olarak iskemik inme %37; hemorajik inme %12; beyin tümörü %13; demans %11.4; metabolik bozukluklar %5.5; nedeni saptanamayan olgular %13; diğer etiyolojiler (normal basınçlı hidrosefali, menenjit, alkolizm vb..) ise %8.1 olarak bildirilmiştir. [13] Yine yaşlı epilepsili olguların incelendiği bir başka çalışmada etiyolojide serebrovasküler olay %50.7; beyin tümörü %10.7; nedeni saptanamayan olgular %22.3 oranında bildirilmiştir. Araştırmacılar nedeni saptanamayan olguların takiplerinde nöbet gelişimini izleyen bir yıl içinde beyin tümörü, kolon ve pankreas tümörü, vasküler demans görüldüğünü bildirmişlerdir.…”

Section: Introductionunclassified

Experiences in an Epilepsy Polyclinic: Epilepsy in the Elderly

Özkan¹

2015

Epilepsi

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SummaryObjectives: Epilepsy is one of the most common serious neurological disorders in the elderly. In this study the demographic and clinical features, etiological factors, seizure types and response ratios to treatment are presented for a group of patients aged 60 years and over diagnosed with epilepsy.Results: Twenty-five patients aged 60 years and over who applied to the epilepsy polyclinic were retrospectively investigated.Results: Average patient age was 75.0±7.1 years and average disease duration was 2.32±1.8 years. Sixteen patients were male and 9 female. Among the patients, cerebrovascular disease (17 patients), brain tumor (1 patient), arachnoid cyst (1 patient), aneurysm (1 patient) and myocardial infarction (1 patient) were considered as the underlying factors in seizure development. In the remaining 4 cases, no etiological cause was determined. Seizure types were; secondary generalized tonic-clonic seizure (20 patients), simple partial seizure (2 patients), status epilepticus seizure (2 patients), and complex partial seizure (1 patient). EEG findings were abnormal in 32% of the patients (n=8). When evaluated for treatment, 18 patients received monotherapy; 6 patients used double, and 1 patient used triple drugs. The follow-up period in 21 cases was without seizure. Conclusion:In the study, the most common etiological cause of epilepsy seen in the elderly was cerebrovascular disease. Seizure type was mainly secondary generalized tonic-clonic. The patients responded well to monotherapy and prognosis was improved.

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Etiological prevalence of epilepsy and epileptic seizures in hospitalized elderly in a Brazilian tertiary center – Salvador - Brazil

Abstract: This study suggests that epilepsy and epileptic seizures in the elderly inpatients have etiological association with stroke, neoplasias and dementias.

Cited by 27 publications

References 29 publications

Towards a clinically informed, data‐driven definition of elderly onset epilepsy

Towards a clinically informed, data‐driven definition of elderly onset epilepsy

Inflammatory signs and epileptic crisis in patients admitted in an emergency unit

Experiences in an Epilepsy Polyclinic: Epilepsy in the Elderly

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