Etiological profile of short stature

Bhadada, Sanjay Kumar; Agrawal, N. K.; Singh, Seema; Agrawal, J K

doi:10.1007/bf02723154

Cited by 33 publications

(50 citation statements)

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“…To date the data point out that the causes are most likely heterogenous, including delay in physical maturity [5][6][7][8][9], suboptimal nutrition [4,10,11], genetic factors and GH-IGF axis abnormalities [4,5,9,[12][13][14]. Therefore a careful investigation of the components related to the GH-IGF-I axis, nutrition and maturity should be carried out in patients with growth failure who are categorized as "idiopathic" or "normal variant" short stature.…”

Section: Discussionmentioning

confidence: 99%

“…In order to have a strict classification, those patients who could not be differentiated as FSS or CDGP were not included in the study. Target heights of the subjects (which are calculated from heights of their parents) [21] were similar to their predicted heights (which are calculated by using bone ages according to the Greulich and Pyle atlas) [5,22,23].…”

Section: Methodsmentioning

confidence: 96%

“…The definition of idiopathic short stature (ISS) remains somewhat controversial. Some authors prefer to categorize all the children with unknown cause of short stature as ISS [1,2], while some authors prefer to classify those with bone age appropriate for chronological age whose parents are in the range of short stature as familial short stature (FSS) and those who has bone age retardation (at least one year) with a family history of delayed pubertal maturation as constitutional delay of growth (and puberty) [CDG(P)], giving the name ISS to the rest [3][4][5]. Although FSS and CDGP are considered as "normal variants", studies reveal that final height is compromised as a result of the natural course in FSS and as a result of yet undefined reasons in CDGP [3].…”

mentioning

confidence: 99%

“…The suggested causes of poor growth in children with ISS are most likely heterogenous, i.e. delay in physical maturity [5][6][7][8][9], suboptimal nutrition [4,10,11], genetic factors and growth hormone (GH) -insulin-like growth factor (IGF) axis abnormalities [4,5,9,[12][13][14].…”

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confidence: 99%

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Serum Ghrelin, IGF-I and IGFBP-3 Levels In Children with Normal Variant Short Stature

et al. 2006

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Abstract. This study is planned to investigate the role of ghrelin in normal variant short stature. Serum ghrelin, IGF-I and IGFBP-3 levels were measured in 17 children with constitutional delay of growth, 19 children with familial short stature and 11 age matched healthy children. Mean bone age of the constitutional delay of growth group was lower compared to other groups. Constitutional delay of growth group had lower mean weight compared to the controls. Serum IGF-I values were lower in the constitutional delay of growth group compared to the familial short stature and control groups. IGFBP-3 levels of the groups were similar. Ghrelin levels were higher in the short stature groups compared to the controls. In the multiple regression analyses, weight (β = -.54, p<0.0001) and height SDS (β = -.33, p = 0.01) were the independent determinants of ghrelin. The results of this study, the first one in which ghrelin levels are investigated in normal variant short stature, suggest that ghrelin does not play a role as a cause, but as a consequence in these patients because it is negatively correlated with weight and height standard deviation score. These negative correlations can be attributed to the compensatory response of ghrelin, which deserves further attention in future studies.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 96%

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confidence: 99%

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Serum Ghrelin, IGF-I and IGFBP-3 Levels In Children with Normal Variant Short Stature

et al. 2006

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“…Boy kısalığında da genetik etmenler önem taşır. Boy kısalığı yapan etiyolojik etmenlerinin dağılımında da ülkeden ülkeye, hatta aynı ülke içinde bölgesel farklılıklarda gösterebilmektedir (12,22). Bunların hangisinden kaynaklandığını saptamak için daha ileri girişimsel çalışmaların yapılmasına gereksinim vardır.…”

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The Prevalence of Obesity in First Year Primary School Students in Nine Districts of İzmir Province

Turhan¹

2015

Ann Clin Anal Med

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ÖzetAmaç: Dünya Sağlık Örgütü (WHO)'ne göre obezite ve fazla kiloluluk sağlı-ğı bozacak şekilde, vücutta anormal ve aşırı yağ birikmesidir. Son yıllarda tüm dünyada çocukluk döneminde obezite ve fazla kiloluk sıklığı artmaktadır. Çalışmanın amacı İzmir'e bağlı dokuz ilçede ilköğretim 1. sınıf öğrencile-rinde obezite sıklığının belirlenmesidir. Gereç ve Yöntem: Çalışma kesitsel tiptedir. İzmir'e bağlı ilçelerden basit rastgele örnekleme yöntemi ile dokuz ilçe seçilmiştir (Aliağa, Beydağ, Dikili, Foça, Güzelbahçe, Kınık, Ödemiş, Seferihisar, Selçuk). WHO'nun 2007 yılı referans değerlerine göre çocukların yaşa göre ağırlık, yaşa göre beden kitle indeksi (BKİ) ve yaşa göre boy Z skorları hesaplanmıştır. Yaşa göre boy, yaşa göre BKİ ve yaşa göre ağırlık z skorları, +2 standart sapmadan büyük olan çocuklar, uzun boylu ve obez olarak değerlendirilmiştir. Verilerin analizinde Ki kare testi ve t testi kullanılmıştır. İsta-tistiksel anlamlılık sınırı olarak p<0.05 değeri kabul edilmiştir. Bulgular: Araş-tırmaya katılan çocukların; yaş ortalaması 6,4± 0,6, boy ortalaması 117,0± 6,4 ve kilo ortalaması 21,5± 4,5kg'dır. Çocukların antropometrik değerlen-dirmelerine göre, %3,8'nin düşük kilolu, %7,6'sının obez ve %3,3'ünün bodur ol-duğu belirlenmiştir. Erkek çocukların %8,8'inin obez, %3,2'sinin bodur; kız çocukların %6,3'ünün obez, %3,4'ünün ise bodur olduğu saptanmıştır. Tartış-ma: Bu çalışmada obezite sıklığı ülkemizde yapılan diğer çalışmalardan biraz daha yüksek saptanmıştır. Çocuklarda obezitenin azaltılması için bu yaş grubu çocuklar gelecek yıllarda da takip edilmeli, aileler obezite konusunda bilinçlendirilmelidir. Anahtar KelimelerObezite; Beden Kitle İndeksi; Okul Çocuğu; İzmir Abstract Aim: Obesity and overweight are defined by the World Health Organization (WHO) as ''abnormal or excessive fat accumulation that may impair health''. The prevalence of childhood obesity and overweight has been increased worldwide in recent decades. To determine the prevalence of obesity in first year primary school students in nine districts of İzmir province. Material and Method: This study was planned as cross-sectional research, and performed on nine districts selected by simple random method in Izmir province (Aliağa, Beydağ, Dikili, Foça, Güzelbahçe, Kınık, Ödemiş, Seferihisar, Selçuk). The height and the weight figures of each child were noted and Z values were calculated with reference to WHO 2007 standards. Children whose Z scores of "height for age" ,"BKİ for age" and "weight for age" are higher than + 2 standard deviation were assessed as tall and obese. In analyzing data Chi-square test and t test were used. Statistical significance value was accepted as p<0.05. Results: The average data and their standard deviation for the children were as follows: age 6,4± 0,6 years, height 117,0± 6,4 cm and weight 21,5± 4,5kg. According to the anthropometric measurements 3,8% of the children were under-weight (Weight SDS<-2SD), 7,6% were obese (Weight SDS>+2SD) and 3,3% were stunted (height SDS<-2SD). When a comparison is made based on ...

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Assessing the maternal risks associated with short stature in ancient Southeast Asia

Tiel

McFadden

2021

Intl J of Osteoarchaeology

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The maternal experience in ancient Southeast Asia has been an area of study not yet addressed in bioarchaeological research due to the challenges associated with evaluating it and the lack of tools available. This study aims to better our knowledge of the maternal experience in ancient Southeast Asia by investigating whether there is a relationship between maternal mortality rates and a known maternal risk factor, stature, which can be estimated from archaeologically derived skeletal remains. This is performed by applying an adapted maternal mortality rate estimator and undertaking analyses based on stature estimates from ancient Southeast Asian archaeological samples. By investigating estimated stature and maternal mortality rates, we are able to look at whether the modern risks associated with pregnancy in short statured females were also seemingly applicable in the past in Southeast Asia. This study identified that, at the population level, a decrease in average stature coincided with an increase in maternal mortality rates. These results emulate modern trends, with shorter statured females being at a higher risk of maternal death and often requiring medical intervention due to complications caused by their short stature and associated small pelvis. These findings contribute to our understanding of the maternal risk associated with short stature in ancient Southeast Asia.

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Etiological profile of short stature

Abstract: In males most common cause of short stature was constitutional growth delay, while in females most common cause of short stature was familial short stature.

Cited by 33 publications

References 2 publications

Serum Ghrelin, IGF-I and IGFBP-3 Levels In Children with Normal Variant Short Stature

Serum Ghrelin, IGF-I and IGFBP-3 Levels In Children with Normal Variant Short Stature

The Prevalence of Obesity in First Year Primary School Students in Nine Districts of İzmir Province

Assessing the maternal risks associated with short stature in ancient Southeast Asia

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