Etiological Spectrum of Post-Transfusion Hepatitis

Studies of the aetiology of neonatal hepatitis and biliary atresia.

“…This figure should also indicate the proportion of pregnant women harbouring agents capable of causing hepatitis and should correspond to the frequency of subclinical hepatitis after blood transfusion-also 5-10% (Hampers et al, 1964;Creutzfeldt et al, 1966;Proskey et al, 1970). This figure is much higher than the frequency of HBs antigenaemia, and other agents must be proposed in addition to the hepatitis B (Knodell et al, 1975). Intrauterine transfusions in severe HDN should raise the frequency of the 'inspissated bile syndrome' by exposing the fetus to donor blood in addition to the mother-this is also true.…”

Recent advances in the identification of hepatitis viruses

“…A significant proportion of sporadic hepatitis has also been attributed serologically to HAV. On the other hand, although HAV can be transmitted experimentally by parenteral inoculation, type A hepatitis has not been confirmed serologically as a significant contribution to transfusion-associated hepatitis Knodell et al, 1975), haemodialysis-associated hepatitis (Zuckerman, Courouce and Szmuness, unpublished data), drug abuse-related hepatitis (Mosley et al, 1977), or other forms of percutaneous transmission via blood and , 292, 1141. 1975.…”

“…Application of these sensitive tests revealed that many transfusionassociated cases were not caused by HBV, and recent serological testing for anti-HA has failed to incriminate HAV also Knodell et al, 1975). Cases of hepatitis which are serologically neither type A nor type B also occur among drug abusers (Mosley et al, 1977), haemodialysis patients (Zuckerman and Courouce, unpublished data), intrafamily contacts , and intrainstitutional contacts (Ogra, unpublished data).…”

Molecular Characterization of Hepatitis C Virus

“…However, serological prescreening of blood donors for HBV antigens resulted in only moderate reductions in the frequency of posttransfusion hepatitis, suggesting that a second, parenterally transmitted hepatitis agent might exist in the population. Serological analysis confirmed that the etiological agent in approximately 90% of the remaining hepatitis cases was neither HAV nor HBV [4]. In 1978, the NANBH agent was shown to be transmissible to chimpanzees, as evidenced by the development of liver pathology such as characteristic, cytoplasmic tubular structures [5][6][7].…”