Etiological Structure of Enterovirus Infections in the Russian Federation in 2017–2018

Голицына, Л. Н.; Зверев, В. В.; Selivanova, S.G.; Пономарева, Н.В.; Kashnikov, A. Yu.; Sozonov, D. V.; Сашина, Т. А.; Епифанова, Н. В.; Евплова, И. А.; Rezaykin, A.V.; Sapega, E. Yu.; Novikova, N. A.; Ефимов, Е. И.

doi:10.35627/2219-5238/2019-317-8-30-38

Cited by 10 publications

(2 citation statements)

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“…Enteroviruses A-D species genus Enteroviruses family Picornaviridae are associated with human enteroviral infection. Enteroviral infection (EVI) is characterized by a wide diversity of clinical forms, including enteroviral meningitis, meningoencephalitis, hand-foot-and-mouth disease (HFMD), and other clinical manifestations [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Enterovirus 71-Associated Infection in South Vietnam: Vaccination Is a Real Solution

Romanenkova

Nguyen²,

Голицына

et al. 2023

Vaccines

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Hand-foot-and-mouth disease (HFMD) is the most common enteroviral infection in South-East Asia. When evaluating the role of enterovirus 71 (EVA71) as an etiological agent of infectious disease in South Vietnam, we revealed a high proportion of EVA71 among identified species A enteroviruses found in 3542 samples from HFMD cases; 125 samples from cases of enteroviral meningitis; and 130 samples from acute flaccid paralysis (AFP) cases. These represent 50%, 54.8%, and 51.5%, respectively. According to molecular analysis, 90% of EVA71 were attributed to genotype C4 and 10% were attributed to genotype B5. The predominance of EVA71 circulation among the population proves the need to strengthen surveillance (with monitoring of enterovirus circulation for facilitation of HFMD outbreak prediction) and to increase the effectiveness of preventative measures by the implementation of vaccination against EVA71-associated infections. A phase III trial of a Taiwanese vaccine (EV71vac) in Taiwan and South Vietnam showed its safety, tolerability, and efficacy in children aged 2–71 months. This B4 genotype-based vaccine, which features cross-protection against B5 and C4 genotypes, and other existing EV71 vaccines can serve as a good approach to solving the HFMD problem, which is so important for Vietnam.

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Section: Introductionmentioning

confidence: 99%

Enterovirus 71-Associated Infection in South Vietnam: Vaccination Is a Real Solution

Romanenkova

Nguyen²,

Голицына

et al. 2023

Vaccines

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“…However, dynamics of incidence with EVnI in the RF shows that it still apparently tends to grow. According to some authors, this trend occurs due to a change in dominating virulent NPEV variants [11,12]; according to others, with incidence being revealed more efficiently due to improved laboratory diagnostics 4 [13].…”

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confidence: 99%

New Approaches to Assessing and Forecasting Morbidity With Enterovirus (Non-Polio) Infection in the Russian Federation Using Mathematical Models

Фельдблюм¹,

Акимкин²,

Алимов³

et al. 2021

Health Risk Analysis

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At present it is impossible to develop epidemiologic surveillance and control over any infection regarding studies on dynamics of morbidity, seasonality and periodicity without using mathematical modeling techniques. Our research goal was to study regularities in manifestations of epidemic process for enterovirus (non-polio) infection (EVnI) in the Russian Federation over 14 years (2006–2019) using mathematical models (linear, logarithmic, power, and exponential approximation).An optimal mathematical model was selected using three statistical parameters, namely determination coefficient, Fischer’s exact test, and standard error. Periodicity of rises and falls in morbidity was calculated with Fourier one- dimensional spectral analysis. Intra-year dynamics of morbidity with EVnI was estimated basing on monthly spread of the disease cases on the RF territory. Classic seasonal decomposition, Census I technique, was applied to analyze time series of monthly morbidity. It was determined that EVnI epidemic process was unevenly spread over years in the RF in the examined period of time (2006–2019) and there were two opposite trends in it; the first one lasted from 2006 to 2010 when morbidity was declining and the second was from 2010 to 2019 when it was growing. Having analyzed manifestations of EVnI epidemi- ologic process in long-term dynamics given its uneven spread as per years, we established that it was advisable to use mathematical models approximated as per separate time periods. Average long-term morbidity with EVnI amounted to 8.09 0/0000 in the RF in 2010–2019 with growth rate being equal to 17.7 %. Maximum value was registered in 2017 (16.32 0/0000). An unfavorable prediction for further epidemic situation development was revealed for the examined pe- riod. The epidemic process was characterized with 4-year periodicity and summer-autumn seasonality with peaks usually occurring in August and September. Rates that characterized intensity of the trends in long-term morbidity dynamics and were calculated with mathematical models differed authentically from those obtained via conventional calculations of average values (χ=11.08; d.f.=1; p=0.0009).

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Epidemiological and etiological aspects of enterovirus infection in Russia and Vietnam

Romanenkova

Голицына

Nguyen

et al. 2021

Russian Journal of Infection and Immunity

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The epidemic situation and etiological factors of enterovirus infection in Russia and Vietnam were analysed and compared. The identified strains of enteroviruses of 47 types, which circulated in Russia in 2018–2019, belonged to different species: Enterovirus species A (CV-A2, CV-A4, CV-A6, CV-A8, CV-A10, CV-A16, EV-A71), as well as Enterovirus species B and Enterovirus species C. The strains isolated from 87 children from southern Vietnam hospitalised in 2018–2019 into infectious hospitals while having enterovirus infection with exanthema were also studied. All identified strains were represented by Enterovirus species A: EV-A71 — 59 strains, CV-A10 — 20 strains, CV-A16 — 5 strains, CV-A6 — two strains and CV-A2 — one strain. Out of 59 viruses EV-A71, 53 strains belonged to genotype C4 and 6 strains belonged to genotype B5. The sequences of EV-A71 strains of genotype C4 from South Vietnam formed a monophyletic cluster with the sequences of EV-A71 viruses which circulated during 2016–2018 in different provinces of China, and they were very close to EV-A71 strains of the same genotype from the Yunnan Province. These strains were genetically different from Russian viruses and Vietnamese viruses identified in the years 2003–2005 and 2011– 2012. Most of the cases of enterovirus infection from southern Vietnam (78%) caused by EV-A71 virus of genotype C4 were reported in three provinces located in southern Vietnam in the Mekong Delta. The epidemic process and the etiology of enterovirus infection in Russia and Vietnam have common features. At the same time, the epidemic situation in these countries is not the same. The incidence of enterovirus infection is influenced by geographic, climatic, economic and demographic factors that differ in two countries. In the majority of territories of Russia, the climate is temperate or cold, seasonal rises in the incidence rates of enterovirus infection usually occur in the summer, when people go on vacation, spend a lot of time outdoors and swim in open reservoirs. In Vietnam, a constant high-level temperature, a high population density and a large proportion of children determine the higher incidence of enterovirus infection, especially in the southern provinces of Vietnam, compared to Russia. The fact that more than 20% of the Vietnamese population lives in the Mekong Delta, which is the largest river in Indochina, has a significant impact on the epidemic process of enterovirus infection in South Vietnam. The Mekong River which flows through China, Laos, Thailand, Cambodia and Vietnam, and carries huge streams of water, including rainstorm waters and sewages, from all of these countries into the southern provinces of Vietnam, which have the highest incidence rates of enterovirus infection in the country. The results of the research underline the importance of active epidemiological and virological surveillance of enterovirus infection, which plays the key role in informing the public health authorities about the changes in the epidemic situation in order to take appropriate measures and develop the prevention strategies. The goal of anti-epidemic and preventive measures is to reduce the incidence of enterovirus infection and the economic burden of this infection for Russia and Vietnam.

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Etiological Structure of Enterovirus Infections in the Russian Federation in 2017–2018

Cited by 10 publications

References 0 publications

Enterovirus 71-Associated Infection in South Vietnam: Vaccination Is a Real Solution

Enterovirus 71-Associated Infection in South Vietnam: Vaccination Is a Real Solution

New Approaches to Assessing and Forecasting Morbidity With Enterovirus (Non-Polio) Infection in the Russian Federation Using Mathematical Models

Epidemiological and etiological aspects of enterovirus infection in Russia and Vietnam

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