Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China

Wang, Zemin; Tang, Lili; Sun, Guiju; Tang, Yuntian; Xie, Yin; Wang, Shaokang; Hu, Xu; Gao, Weimin; Cox, Stephen B.; Wang, Jiasheng

doi:10.1186/1471-2407-6-287

Cited by 101 publications

(95 citation statements)

References 46 publications

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“…We included only studies with case -control or cohort design, the former limited to those that used control subjects without upper gastrointestinal cancers. Using these approaches, we found 55 full-text articles, among which 2 (Wang et al, 1992;Chen et al, 2003) reported the results from 3 and 2 individual studies, respectively, making the total number retrieved 58, of these 24 were excluded because: (i) no risk estimates or crude numbers of cases and controls for the exposureof-interest were reported (Shen et al, 1999;Wang et al, 2006); (ii) the method of pickling vegetables differed from those in East and Southeast Asia (Onuk et al, 2002;Sapkota et al, 2008); (iii) results were only reported in combination with other foods (Hou et al, 1999;Lu et al, 2000;Wang et al, 2004;Xie et al, 2005;Pan et al, 2006) or in combination with other cancers (Li et al, 1989;Yu et al, 1993;Tong et al, 2001;Zhang et al, 2001; one of the three studies reported in Chen et al, 2003); and (iv) results were also reported in other publications (Chu and Ye, 1992;Chu et al, 1992a,b;Guo et al, 1994;Cheng et al, 1995;Li et al, 2001;Xu et al, 2002;Li et al, 2007;Feng et al, 2008a; another one of the three studies reported in Chen et al, 2003). Finally, 34 studies remained in the meta-analysis.…”

Section: Methodsmentioning

confidence: 99%

Pickled vegetables and the risk of oesophageal cancer: a meta-analysis

et al. 2009

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BACKGROUND: Ecological and experimental studies have suggested a relationship between Asian pickled vegetable consumption and oesophageal squamous cell carcinoma (OSCC), but the results of epidemiological studies investigating the association have been inconsistent. We conducted a meta-analysis of observational studies of this association to evaluate the existing evidence. METHODS: We searched the PubMed, ISI-Web of Science, J-EAST, IndMed, Vip Chinese Periodical, and China National Knowledge Infrastructure databases for all studies published in English or Chinese languages. Pooled results for all studies combined and for several study subgroups were computed. RESULTS: A total of 34 studies were included in this analysis. The overall random effects odds ratio (OR) and 95% confidence interval (CI) for pickled vegetable consumption was 2.08 (1.66 -2.60), but the results were heterogeneous across studies. After excluding the three most influential studies, the respective numbers were 2.32 (1.92 -2.81). Similar to the overall association, the majority of subgroup analyses showed a statistically significant association between consuming pickled vegetables and OSCC risk. There were only three prospective studies. CONCLUSIONS: Our results suggest a potential two-fold increased risk of oesophageal cancer associated with the intake of pickled vegetables. However, because the majority of data was from retrospective studies and there was a high heterogeneity in the results, further well-designed prospective studies are warranted.

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Section: Methodsmentioning

confidence: 99%

Pickled vegetables and the risk of oesophageal cancer: a meta-analysis

et al. 2009

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“…33 Wang et al reported that eating fast significantly increased the risk of esophageal cancer with an OR of 3.39 (95% CI: 1.15-9.95). 34 Eating too quickly can cause irritation of the esophageal mucosa and lead to chronic esophagitis, which has been considered an early sign of malignant transformation of the squamous epithelium. 35 Moreover, irritation may increase cell turnover and increase the contact between carcinogens and dividing target cells, thus making the esophagus more susceptible to cancer.…”

Section: Epidemiologymentioning

confidence: 99%

Does family history of cancer modify the effects of lifestyle risk factors on esophageal cancer? a population‐based case–control study in China

Zhang

Kampman

et al. 2011

Intl Journal of Cancer

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A population-based case-control study on esophageal cancer has been conducted since 2003 in Jiangsu Province, China. The aim of this analysis is to provide further evidence on the relationship between family history of cancer in first-degree relatives (FH-FDRs) and the risk of esophageal cancer, and to explore the joint effects for FH-FDR with major lifestyle risk factors. A total of 1,520 cases and 3,879 controls were recruited. Unconditional logistic regression was applied for evaluating independent association as well as potential interactions between FH-FDR and lifestyle risk factors on the risk of esophageal cancer. Population attributable fraction (PAF) was calculated to quantify the proportion of cases attributable to risk factors. Results showed that with a FH-FDR of any malignant tumor or esophageal cancer, there is a 1.64-and 2.22-fold risk of esophageal cancer, respectively. Association was increased when there was more than one affected FDR (OR 5 3.14) and younger age at diagnosis of relatives. Exposure of both FH-FDR and lifestyle risk factors strongly associated with esophageal cancer. Significant superadditivity interaction was found for FH-FDR with fast eating speed and diets low in fruits and vegetables. The estimation of PAF indicated that the majority of cases were attributed to lifestyle risk factors. In conclusion, it was found that FH-FDR significantly increases the risk of esophageal cancer and could modify the effect of certain lifestyle risk factors. If comprehensive lifestyle interventions are carried out within high-risk populations, there is a high probability of curbing occurrences of esophageal cancer.Esophageal cancer is one of the most common cancers worldwide, with $462,000 new cases and 386,000 deaths each year. China is an area with one of the highest incidences of esophageal cancer worldwide. Each year, about one-half of the cases of esophageal cancer that occur in the world are estimated to be in China. 1 According to the results of a national mortality retrospective survey conducted in 2006, esophageal cancer was the fourth leading cause of cancer death in China, with a national average age-standardized mortality of 15.2/100,000. 2 Squamous cell carcinoma of the esophagus remains the predominant histological subtype, representing more than 95% of total cases in the Chinese population. 3 The etiology of esophageal cancer shows that it is multifactorial. A number of studies have suggested that lifestyle factors are significant to the development of this disease. Tobacco smoking and alcohol consumption are responsible for a high fraction of esophageal cancer occurrence; more than 90% of cases could be attributed to these two factors in Western countries. 4 Dietary factors such as ingestion of hot foods and drinks, fast eating speed, nutrition deficiency and high intake of carcinogens from pickled vegetables have been suggested to contribute to most cases of esophageal cancer in high-risk areas such as China and Iran. 5,6 Moreover, genetics and other endogenous factors may also ...

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“…Variations in enzyme activity of EPHX1 as a result of such polymorphisms may lead to interindividual variations in susceptibility to chemical carcinogen-induced cancers, including EC. Although some studies have attempted to link EPHX1 gene Tyr113His and His139Arg polymorphisms to EC, the resulting data are not often reproducible (Zhang et al, 2003;Casson et al, 2003Casson et al, , 2006Lin et al, 2006;Wang et al, , 2006Jain et al, 2008;Ihsan et al, 2010;Dura et al, 2012). As a caveat, failure of replication may result from the genetic heterogeneity between different races or ethnicities, as well as individual studies with relatively low statistical power.…”

Section: Introductionmentioning

confidence: 99%

“…Further application of our inclusion/exclusion criteria left 9 articles (Zhang et al, 2003;Casson et al, 2003Casson et al, , 2006Lin et al, 2006;Wang et al, 2003Wang et al, , 2006Jain et al, 2008;Ihsan et al, 2010;Dura et al, 2012), including 8 studies for the Tyr113His polymorphism with 1158 EC cases and 1868 controls Zhang et al, 2003;Casson et al, 2003Casson et al, , 2006Lin et al, 2006;Jain et al, 2008;Ihsan et al, 2010;Dura et al, 2012), and 7 studies for His139Arg with 901 EC and 1615 controls Casson et al, 2003Casson et al, , 2006Lin et al, 2006;Jain et al, 2008;Ihsan et al, 2010;Dura et al, 2012). The detailed selection process and the baseline characteristics of the qualified studies are presented in Figure 1 and Table 1, respectively.…”

Section: Description Of Available Studiesmentioning

confidence: 99%

Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk

Hu¹,

Wang²,

Li³

2013

Genet. Mol. Res.

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ABSTRACT. Epoxide hydrolases metabolize exogenous chemicals, including carcinogens such as polycyclic aromatic hydrocarbons. The relationship between microsomal epoxide hydrolase 1 (EPHX1) polymorphisms and esophageal cancer risk has been investigated in various ethnic populations, but the results have been contradictory. We investigated the association of EPHX1 Tyr113His and His139Arg polymorphisms with esophageal cancer via a comprehensive metaanalysis. Publications before August 20, 2012 were included. Eight studies concerning Tyr113His polymorphism associated with 1158 esophageal cancer cases and 1868 controls were identified; 7 studies concerning association of His139Arg with 901 esophageal cancer cases and 1615 controls were also included. A random-effect model was applied, irrespective of between-study heterogeneity. Data and study quality were assessed in duplicate. No significant association was found in either the allele or genotype models for Tyr113His or His139Arg EPHX1 polymorphisms and esophageal cancer risk polymorphism with risk for esophageal cancer. Lack of association was also identified in stratified analyses by ethnicity. No publication bias was observed. We conclude that current evidence does not demonstrate association of EPHX1 Tyr113His or His139Arg polymorphisms with risk for development of esophageal cancer.

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Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China

Cited by 101 publications

References 46 publications

Pickled vegetables and the risk of oesophageal cancer: a meta-analysis

Pickled vegetables and the risk of oesophageal cancer: a meta-analysis

Does family history of cancer modify the effects of lifestyle risk factors on esophageal cancer? a population‐based case–control study in China

Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk

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