Etiologies and Characteristics of Choroidal Neovascularization in Young Chinese Patients

Abstract

Purpose: To investigate the etiologies and characteristics of choroidal neovascularization (CNV) in young Chinese patients. Methods: A retrospective review of young Chinese patients (< 50 years of age) with CNV from January 2010 to June 2016 was performed. Results: Of the 501 patients (537 eyes) with CNV, 58.7% were female, and 7.2% had bilateral CNV. The mean age was 35 years. The etiologies were idiopathic CNV (ICNV, 43.9%), pathologic myopia (PM, 21.9%), punctate inner choroidopathy (PIC, 17.4%), polypoidal choroidal vasculopathy (4.4%), multifocal choroiditis with panuveitis (3.6%), and other disorders (8.8%). Five hundred and six CNVs (94.2%) showed a predominantly classic CNV composition on fundus fluorescein angiography (FFA) and 316 CNVs (96.6%) were type 2 CNV on optical coherence tomography (OCT). Conclusion: The etiologies of CNV in young Chinese patients were diverse, and ICNV, PM, and PIC were the three most common etiologies. Most CNVs were classic on FFA and type 2 on OCT.

Spectral domain-optical coherence tomography retinal biomarkers in choroidal neovascularization of multifocal choroiditis, myopic choroidal neovascularization, and idiopathic choroidal neovascularization

“…CNV is a pathological change that occurs in a variety of retinal and choroidal diseases and seriously affects patients' vision and reduces their quality of life [10]. Previous research has found that the most common aetiologies of CNV among young patients are pathologic myopia, inflammation, and ICNV [10,20].…”

“…CNV is a pathological change that occurs in a variety of retinal and choroidal diseases and seriously affects patients' vision and reduces their quality of life [10]. Previous research has found that the most common aetiologies of CNV among young patients are pathologic myopia, inflammation, and ICNV [10,20]. Usually, CNV secondary to MFC can be differentiated from mCNV lesions by the presence of vitreous cells and via fundus examination according to the characteristic yellow-white or punched-out lesions that present with early hyperfluorescence and late fluorescence leakage in FFA in the same or the fellow eye [11].…”

“…CNV diagnosis was confirmed by the presence of early phase hyperfluorescence with latephase leakage on fundus fluorescein angiography (FFA). ICGA, optical coherence tomography angiography (OCTA) and SD-OCT were performed to assist in the diagnosis of CNV [10]. Patients were included in the MFC group if they had idiopathic, multiple yellowwhite choroidal lesions or punched-out lesions visible on colour fundus photography, and the CNV features mentioned above (Figure 1) [6].…”

“…Patients with a refractive error of À6 D or worse, along with fundus changes and the typical manifestations of CNV and without other fundus lesions [11] (Figure 1), were included in the mCNV group. Patients were added to the ICNV group if the cause of CNV could not attributed to any ocular or systemic disease [10] (Figure 1). The exclusion criteria were as follows: (1) patients with any ocular diseases other than pathological myopia of MFC/ PIC; (2) patients whose diagnosis was unclear and difficult to classify; (3) patients who had undergone previous treatment and had old CNV lesions; (4) patients who had systemic inflammation or an infectious disease; and (5) poor image quality that prevented recognizing the disease.…”

Clinical Features of Pediatric Choroidal Neovascularization and Outcomes of Treatment with Intravitreal Anti-VEGF in Korean Patients

“…Several treatment methods have been introduced for pediatric CNV [8][9][10], but the recent therapeutic paradigm is shifting toward the use of anti-vascular endothelial growth factor (VEGF) [11]. Several studies have reported the usefulness of anti-VEGF in pediatric CNV, but most are retrospective case series reports [2,4,6,7,11,12], and studies in Asian patients are few [6,13]. Recently, a study on pediatric CNV patients using a large database was reported [14].…”