Etiology and management of Alzheimer’s disease: Potential role of gut microbiota modulation with probiotics supplementation

Dasriya, Vaishali; Samtiya, Mrinal; Dhewa, Tejpal; Puniya, Monica; Kumar, Sanjay; Ranveer, Soniya; Chaudhary, Vishu; Vij, Shilpa; Behare, Pradip; Singh, Namita; Aluko, Rotimi E.; Puniya, Anil Kumar

doi:10.1111/jfbc.14043

Cited by 21 publications

(7 citation statements)

References 199 publications

(202 reference statements)

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“…The development of Alzheimer's disease [69,[88][89][90][91][92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107] and the mechanisms through which the microbiome can contribute to the progression of Alzheimer's disease have been investigated . Numerous studies are also available regarding treatments with probiotics [139][140][141][142]. In one study [143], it was observed that the consumption of a combined probiotic preparation (Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum, and Lactobacillus fermentum) for 12 weeks had a significantly positive impact on the cognitive abilities of the study participants in the Mini-Mental State Examination compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Fekete,

Lehoczki,

Major

et al. 2024

Nutrients

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Recent research exploring the relationship between the gut and the brain suggests that the condition of the gut microbiota can influence cognitive health. A well-balanced gut microbiota may help reduce inflammation, which is linked to neurodegenerative conditions. Prebiotics, probiotics, and symbiotics are nutritional supplements and functional food components associated with gastrointestinal well-being. The bidirectional communication of the gut–brain axis is essential for maintaining homeostasis, with pre-, pro-, and symbiotics potentially affecting various cognitive functions such as attention, perception, and memory. Numerous studies have consistently shown that incorporating pre-, pro-, and symbiotics into a healthy diet can lead to improvements in cognitive functions and mood. Maintaining a healthy gut microbiota can support optimal cognitive function, which is crucial for disease prevention in our fast-paced, Westernized society. Our results indicate cognitive benefits in healthy older individuals with probiotic supplementation but not in healthy older individuals who have good and adequate levels of physical activity. Additionally, it appears that there are cognitive benefits in patients with mild cognitive impairment and Alzheimer’s disease, while mixed results seem to arise in younger and healthier individuals. However, it is important to acknowledge that individual responses may vary, and the use of these dietary supplements should be tailored to each individual’s unique health circumstances and needs.

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Section: Discussionmentioning

confidence: 99%

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Fekete,

Lehoczki,

Major

et al. 2024

Nutrients

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show abstract

“…Additionally, a systematic review and meta-analysis by Hung et al [ 68 ] observed a significant reduction in the diversity of the gut microbiome of individuals with AD compared to healthy controls. Furthermore, pathogenic microorganisms may contribute to the pathophysiology of AD through the generation of lipopolysaccharides and bacterial amyloid fiber [ 69 , 70 ]. The beneficial effects of probiotics can depend on their strain, but research has linked some species of probiotic bacteria to antioxidant defense [ 71 ].…”

Section: Probioticsmentioning

confidence: 99%

The Role of Dietary Antioxidants and Their Potential Mechanisms in Alzheimer’s Disease Treatment

2023

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with cognitive decline and characterized by amyloid-β plaques and neurofibrillary tau tangles. Although AD’s exact pathophysiology remains unclear, oxidative stress is known to play a role in the neurodegenerative process. Since no curative treatment exists, antioxidants represent a potential treatment for AD due to their ability to modulate oxidative stress. Therefore, this review aims to examine the impact of antioxidant supplementation and its potential mechanisms on cognitive function. The review primarily discusses research articles published between 2012 and 2022 reporting the results of clinical trials involving antioxidant supplementation on cognitive function in individuals with AD. Antioxidant supplementation included probiotics, selenium, melatonin, resveratrol, rosmarinic acid, carotenoids, curcumin, vitamin E, and coenzyme Q. While the studies included in this review did not provide much evidence for the beneficial role of antioxidant supplements on cognitive function in AD, the results varied from antioxidant to antioxidant and among trials examining the same antioxidant. Furthermore, many of the studies’ findings face several limitations, including short trial durations, small sample sizes, and a lack of diversity among study participants. As a result, more research is required to examine the impact of antioxidant supplementation on cognitive function in AD.

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“…Gastrointestinal dysfunction is highly prevalent in PD and can precede motor symptoms by more than a decade [79]. Thus, it may be directly related to the process of α-synuclein misfolding, since it is already well documented that PD patients have α-synuclein aggregates in their colon [77,80,[83][84][85].…”

Section: Gut Microbiota and Pdmentioning

confidence: 99%

The role of microbiota-gut-brain axis in neurodegenerative diseases: biochemical and therapeutic aspects

Ernesto

Damasio

Gontijo

et al. 2023

Explor Neuroprot Ther

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The enteric nervous system (ENS) is considered by some authors as the second human brain, given its fundamental role in the regulation process of the central nervous system (CNS). Recent data from scientific literature have shown the existence of close bidirectional communication between the gut microbiota and the CNS, influencing physiological and biochemical changes related to cognition, emotion, behavior, anxiety, depressive symptoms, and stress. Furthermore, the existence of mediators in the connection between intestinal microorganisms and the CNS is evident, which includes neural networks, signaling, immune, and endocrine responses. However, the mechanisms underlying the effects of gut microbiota on brain processes still need to be determined. Therefore, understanding the relationship between the gut and neurodegenerative diseases (NDs) is essential for developing effective prophylactic alternatives and disease-modifying drugs that can prevent or slow the progression of such diseases. Herein, this short review aimed to present the most recent data from the scientific literature associated with the physiological, biochemical, and cellular aspects involved in the interrelationship between the gut-brain axis and NDs, discussing the role of the intestinal microbiota, and its relationship with CNS disorders.

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Etiology and management of Alzheimer’s disease: Potential role of gut microbiota modulation with probiotics supplementation

Cited by 21 publications

References 199 publications

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

The Role of Dietary Antioxidants and Their Potential Mechanisms in Alzheimer’s Disease Treatment

The role of microbiota-gut-brain axis in neurodegenerative diseases: biochemical and therapeutic aspects

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