Etiology and prognosis of acute liver failure in children

Dhawan, Anil

doi:10.1002/lt.21641

Cited by 82 publications

(78 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is unlikely that any single factor or combination of factors will serve as reliable predictive tools for the multiple causes of ALF in children (6,36). In our series, 74% cases were indeterminate and 16% died, compared with 49% and 9%, respectively, in the PALF study group; however, only 26% of cases in our series were 3 years, compared with 36% in the PALF group study.…”

Section: Discussioncontrasting

confidence: 60%

EEG Abnormalities Are Associated With Increased Risk of Transplant or Poor Outcome in Children With Acute Liver Failure

Hussain

Grimason

Goldstein³

et al. 2014

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

Children with a moderate or severe abnormality of EEG background on admission were significantly more likely to require LT or to die. Children with an HE score ≤ 2, and a normal or only mildly abnormal EEG, were significantly more likely to survive without needing LT. These findings are an initial step toward distinguishing patients with ALF who may recover spontaneously from those who will require LT.

show abstract

Section: Discussioncontrasting

confidence: 60%

EEG Abnormalities Are Associated With Increased Risk of Transplant or Poor Outcome in Children With Acute Liver Failure

Hussain

Grimason

Goldstein³

et al. 2014

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

show abstract

“…In 40–50% of patients presenting with acute liver failure, an etiological diagnosis is not made (Squires 2008; Dhawan 2008). Urea cycle disorders may be underestimated as a cause of acute liver failure.…”

Section: Discussionmentioning

confidence: 99%

“…Among these are several inborn errors of metabolism (Table 1). Recent reviews on acute liver failure in children do not mention urea cycle disorders as a cause (Squires 2008; Dhawan 2008). We describe two unrelated patients presenting with acute liver failure, who were referred for liver transplantation.…”

Section: Introductionmentioning

confidence: 99%

Metabolic investigations prevent liver transplantation in two young children with citrullinemia type I

Groot

Cuppen

Eling

et al. 2010

J of Inher Metab Disea

View full text Add to dashboard Cite

Acute liver failure may be caused by a variety of disorders including inborn errors of metabolism. In those cases, rapid metabolic investigations and adequate treatment may avoid the need for liver transplantation. We report two patients who presented with acute liver failure and were referred to our center for liver transplantation work-up. Urgent metabolic investigations revealed citrullinemia type I. Treatment for citrullinemia type I avoided the need for liver transplantation. Acute liver failure as a presentation of citrullinemia type I has not previously been reported in young children. Although acute liver failure has occasionally been described in other urea cycle disorders, these disorders may be underestimated as a cause. Timely diagnosis and treatment of these disorders may avoid liver transplantation and improve clinical outcome. Therefore, urea cycle disorders should be included in the differential diagnosis in young children presenting with acute liver failure.

show abstract

“…In children older than 3 years, acetaminophen intoxication was the main cause. However, the cause of ALF still remains undetermined in a large proportion of children (5). Some centers with and without liver transplantation (LT) facilities in Turkey have reported their experience of the etiology of ALF in childhood (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Etiologies, outcomes, and prognostic factors of pediatric acute liver failure: A single center’s experience in Turkey

Özçay

Öncel²,

Barış³

et al. 2016

Turk J Gastroenterol

View full text Add to dashboard Cite

Etiology and prognosis of acute liver failure in children

Cited by 82 publications

References 13 publications

EEG Abnormalities Are Associated With Increased Risk of Transplant or Poor Outcome in Children With Acute Liver Failure

EEG Abnormalities Are Associated With Increased Risk of Transplant or Poor Outcome in Children With Acute Liver Failure

Metabolic investigations prevent liver transplantation in two young children with citrullinemia type I

Etiologies, outcomes, and prognostic factors of pediatric acute liver failure: A single center’s experience in Turkey

Contact Info

Product

Resources

About