Etiology and risk factors of stroke in young adults: A multicentric study

Aslam, Ayesha; Khan, Ubaid; Niazi, Farheen; Mansoor, Sheikh

doi:10.1016/j.amsu.2022.104647

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…The 90-day functional outcomes measured using the modified Rankin Scale scoring systems of the younger group tended to be superior, represented by more patients with favorable outcomes (mRS 0–2) despite the lack of statistical significance due to the scarce number of patients. Aslam A. et al .’s study also has a similar tendency of excellent functional outcomes in younger patients compared to elderly strokes, emphasizing the essential role of determination of stroke etiology for the most appropriate approach to secondary stroke prevention [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

The diagnostic tests and functional outcomes of acute ischemic stroke or transient ischemic attack in young adults: A 4-year hospital-based observational study

Sakseranee,

Sethabouppha,

Pattarasakulchai

et al. 2023

PLoS ONE

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Background and objectives Ischemic strokes in young adults have been a significant concern due to various potential etiologies and had substantial clinical and public health impacts. We aimed to study the diagnostic tests, etiologies, and functional outcomes of acute ischemic stroke (AIS) and transient ischemic attack (TIA) in young adult patients. Methods The data were retrieved from the Chiang Mai University Hospital Stroke Registry between January 2018 and December 2021. Consecutive AIS or TIA patients were included if they were 18–50 years and had no stroke mimics. Study outcomes were proportions of positive diagnostic tests, and 90-day modified Rankin Scale (mRS). Results Of 244 enrolled patients, 59.0% (n = 144) were male, and 38.1% (n = 93) were aged 18–40, classified as the younger age group. There was a high incidence of diabetes (24.5%) and dyslipidemia (54.3%) among patients aged 41–50, associated with small-vessel occlusion and large-artery atherosclerosis stroke classification in this age group. Patients aged 18–40 years had more other determined etiologies (39.8%), with hypercoagulability (8.2%), arterial dissection (7.8%), and cardiac sources (6.6%) being the first three causes, which were associated with higher anticoagulant treatment. The cerebrovascular study, cardiac evaluation using echocardiography, and antiphospholipid syndrome testing were commonly performed, of which computed tomography angiography provided a high proportion of positive results (80.3%). 76.3% of young adult patients had excellent functional outcomes (mRS 0–1) with a median mRS of 0 (interquartile range 0–1) at 90-day follow-up. Conclusions Stroke of other determined etiology remained the common cause of stroke in young adults, and most affected individuals had excellent clinical outcomes. Blood tests for arterial hypercoagulability and noninvasive vascular and cardiac evaluations are encouraged in selected patients to determine the stroke etiology and guide for appropriate preventive strategies.

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Section: Discussionmentioning

confidence: 99%

The diagnostic tests and functional outcomes of acute ischemic stroke or transient ischemic attack in young adults: A 4-year hospital-based observational study

Sakseranee,

Sethabouppha,

Pattarasakulchai

et al. 2023

PLoS ONE

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“…Taking the study of Sun et al [12] on stroke patients as an example, the risk factors for the occurrence of stroke were obtained through retrospective statistics, which are highly representative. Aslam et al [13] studied the etiology and risk factors for stroke in young adults, and the research results showed that common risk factors for ischemic stroke in the local young population included hypertension, diabetes mellitus and smoking. Wang et al [14] applied a novel metaCCA method to identify the risk genes for stroke that may overlap with seven correlated risk factors, including atrial fibrillation, hypertension, coronary artery disease, heart failure, diabetes, body mass index, and total cholesterol level.…”

Section: Literature Reviewmentioning

confidence: 99%

Stroke Risk Assessment Decision-Making Using a Machine Learning Model: Logistic-AdaBoost

Rao,

Li,

Huang

et al. 2024

CMES

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Stroke is a chronic cerebrovascular disease that carries a high risk. Stroke risk assessment is of great significance in preventing, reversing and reducing the spread and the health hazards caused by stroke. Aiming to objectively predict and identify strokes, this paper proposes a new stroke risk assessment decision-making model named Logistic-AdaBoost (Logistic-AB) based on machine learning. First, the categorical boosting (CatBoost) method is used to perform feature selection for all features of stroke, and 8 main features are selected to form a new index evaluation system to predict the risk of stroke. Second, the borderline synthetic minority oversampling technique (SMOTE) algorithm is applied to transform the unbalanced stroke dataset into a balanced dataset. Finally, the stroke risk assessment decision-making model Logistic-AB is constructed, and the overall prediction performance of this new model is evaluated by comparing it with ten other similar models. The comparison results show that the new model proposed in this paper performs better than the two single algorithms (logistic regression and AdaBoost) on the four indicators of recall, precision, F1 score, and accuracy, and the overall performance of the proposed model is better than that of common machine learning algorithms. The Logistic-AB model presented in this paper can more accurately predict patients' stroke risk.

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A systematic review of the epidemiology and the public health implications of stroke in Sub-Saharan Africa

Abissegue,

Yakubu,

Ajay

et al. 2024

Journal of Stroke and Cerebrovascular Diseases

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Etiology and risk factors of stroke in young adults: A multicentric study

Cited by 4 publications

References 22 publications

The diagnostic tests and functional outcomes of acute ischemic stroke or transient ischemic attack in young adults: A 4-year hospital-based observational study

The diagnostic tests and functional outcomes of acute ischemic stroke or transient ischemic attack in young adults: A 4-year hospital-based observational study

Stroke Risk Assessment Decision-Making Using a Machine Learning Model: Logistic-AdaBoost

A systematic review of the epidemiology and the public health implications of stroke in Sub-Saharan Africa

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