Etiology and Treatment of Leg Cramps

Rt, Mauer

doi:10.1080/00325481.1961.11694324

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Submitted For Publication August 30 19662

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1967

1984

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Cited by 2 publications

(2 citation statements)

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“…Leg cramps frequently occur in association with pregnancy and peripheral venous stasis (14). Other disorders include static foot deformities, degenerative or rheumatoid arthritis and neurologic diseases ( 1,2,12,15). In many cases, however, there is found no underlying disease, local or general.…”

Section: Submitted For Publication August 30 1966mentioning

confidence: 99%

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Use of Chloroquine Phosphate —‐ a New Treatment for Spontaneous Leg Cramps

Parrow

Samuelsson

1967

Journal of Internal Medicine

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Section: Submitted For Publication August 30 1966mentioning

confidence: 99%

“…When treatment of local causes has been without effect numerous drugs have been tried with varying results. Vasodilators have been used without obvious effect (12). Some other drugs, for instance diphenhydramine, diphenylhydantoin, anticholinergics and sedatives, have been tried without effect (18).…”

Section: Submitted For Publication August 30 1966mentioning

confidence: 99%

Use of Chloroquine Phosphate —‐ a New Treatment for Spontaneous Leg Cramps

Parrow

Samuelsson

1967

Journal of Internal Medicine

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Lack of Effect of Cyclandelate in Peripheral Arterial Disease

et al. 1984

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While cyclandelate is widely used in the therapy of peripheral arterial disease, objective evidence of its efficacy remains controversial. For this reason, 12 patients with intermittent claudication (average age of 66.8 years) received both cyclandelate 400 mg qid and placebo in a double-blind crossover trial lasting two months. During the cyclandelate and placebo periods, the following peripheral hemodynamic measurements were obtained using a plethysmograph and treadmill claudication testing: mean calf blood flow, vascular resistance and venous capacitance; finger and toe blood flow, pulsation amplitude and temperature before and after vasodilating maneuvers; arm and leg arterial pulsation amplitudes, one and ten minute calf reactive hyperemia reaction; 30 pound/30 second calf active hyperemia reactions and times of onset of claudication as measured on a treadmill. No major significant difference could be demonstrated between placebo and cyclandelate on any subjective symptom or any objective measurement. It is concluded that cyclandelate 400 mg qid for 4 weeks was of little objective value in treating this group of 12 patients with peripheral arterial disease and suffering from intermittent claudication.

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Etiology and Treatment of Leg Cramps

Cited by 2 publications

References 8 publications

Use of Chloroquine Phosphate —‐ a New Treatment for Spontaneous Leg Cramps

Use of Chloroquine Phosphate —‐ a New Treatment for Spontaneous Leg Cramps

Lack of Effect of Cyclandelate in Peripheral Arterial Disease

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