1999
DOI: 10.1007/pl00015013
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Etiology, Clinical Features and Outcome of Splenic Microabscesses in HIV-Infected Patients with Prolonged Fever

Abstract: A prospective study was conducted to determine the etiology, clinical features, and outcome in a series of 32 consecutively enrolled HIV-infected patients with prolonged fever in whom high resolution (7.5 Mhz) sonography revealed multiple splenic microabscesses. Conventional (3.5 Mhz) sonography showed no splenic abnormalities in any patients. The diagnoses were: tuberculosis (14), visceral leishmaniasis (7), disseminated Mycobacterium avium complex infection (5), Salmonella spp. bacteremia (2), lymphoma (2), … Show more

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Cited by 36 publications
(12 citation statements)
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“…[8][9][10][11]22,25,26 This is likely secondary to a higher degree of difficulty in acquiring this image and increased sensitivity when using the high frequency linear probe in place of the abdominal curvilinear probe, which was not used in our study. 27 As FASH training expands across Malawi and similar resource-limited settings, ample time should be dedicated to training on how to obtain splenic images.…”
Section: Discussionmentioning
confidence: 99%
“…[8][9][10][11]22,25,26 This is likely secondary to a higher degree of difficulty in acquiring this image and increased sensitivity when using the high frequency linear probe in place of the abdominal curvilinear probe, which was not used in our study. 27 As FASH training expands across Malawi and similar resource-limited settings, ample time should be dedicated to training on how to obtain splenic images.…”
Section: Discussionmentioning
confidence: 99%
“…During the screening process, we found 22 articles that discussed the presence of splenic microabscesses in patients with HIV and TB co-infection. [12,21,24,27,28,30,[48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63] These articles were excluded because Murray et al [39] (1995) n=7 (100%), 95% CI 59.0 -100…”
Section: Discussionmentioning
confidence: 99%
“…The presence splenic hypoechoic nodules or micronodules suggestive of splenic microabscesses on abdominal ultrasound and CT scan were highly specific for TB in HIV-patients with disseminated mycobacterial disease, considering it was not seen in patients with NTM infection. Studies have demonstrated a higher prevalence of splenic lesions in HIV-infected patients with disseminated TB compared with those with disseminated NTM [ 30 , 31 ]. Bernabeu-Wittel et al have shown, in 36 patients with HIV infection and splenic microabscesses, that TB and NTM were the aetiology of 43% and 15% of patients respectively [ 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…Studies have demonstrated a higher prevalence of splenic lesions in HIV-infected patients with disseminated TB compared with those with disseminated NTM [ 30 , 31 ]. Bernabeu-Wittel et al have shown, in 36 patients with HIV infection and splenic microabscesses, that TB and NTM were the aetiology of 43% and 15% of patients respectively [ 30 ]. Radin found that 30% of patients with tuberculosis and 7% of patients with MAC had focal lesions in the spleen [ 31 ].…”
Section: Discussionmentioning
confidence: 99%