Etiology of Corpus Callosum Lesions with Restricted Diffusion

Wilson, Christopher; Mullen, Michael T.; Jackson, B.; Ishida, Koto; Messé, Steven R.

doi:10.1007/s00062-015-0409-8

Cited by 19 publications

(12 citation statements)

References 19 publications

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“…Marchiafava–Bignami disease is a rare condition. Wilson et al (2017) reviewed 174 cases of callosal lesions with restricted diffusion. Among them, 47% were vascular and 53% were nonvascular.…”

Section: Discussionmentioning

confidence: 99%

Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava–Bignami Disease: A Case Report and Literature Review

Wang

Fang

et al. 2019

Front. Hum. Neurosci.

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Marchiafava–Bignami disease (MBD) is a rare condition characterized by demyelination, necrosis and atrophy of the corpus callosum (CC), and mainly associated with alcoholism. MBD may present with various clinical manifestations. Brain magnetic resonance imaging (MRI) scan is important in prompt diagnosis and treatment of MBD. Here we reported a case of MBD and reviewed literature about the usage of gadolinium-enhanced MRI in MBD. Gadolinium enhancement may indicate a condition at risk of developing necrosis. We therefore recommend a contrast-enhanced MRI study in severe alcoholics with suspected diagnosis of MBD.

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Section: Discussionmentioning

confidence: 99%

Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava–Bignami Disease: A Case Report and Literature Review

Wang

Fang

et al. 2019

Front. Hum. Neurosci.

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“…Another limitation might be that the etiology of DWI lesions in the brain is diverse and includes vascular as well as non-vascular lesions[ 26 ]. Transient isolated brainstem symptoms frequently precede vertebrobasilar stroke[ 27 ] and in up to 29% of patients with a transient ischemic attack with clinical deficits linked to the brainstem DWI positive lesions can be seen[ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Improved detectability of acute and subacute brainstem infarctions by combining standard axial and thin-sliced sagittal DWI

Schönfeld

Ritzel²,

Kemmling

et al. 2018

PLoS ONE

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Background and purposeMost false negative findings in DWI of ischemic stroke are in patients with minor deficits clinically localized to the brainstem. Our goal was to evaluate the benefit of a thin-sliced sagittal DWI in addition to conventional axial DWI at 1.5T for the detection of brainstem infarctions.MethodsData of patients with symptoms consistent with acute and subacute brainstem infarction and an MRI examination including standard axial DWI and thin-sliced sagittal DWI were retrospectively analyzed. Patients with the later diagnosis of a TIA, an inflammation or a tumor of the brainstem were excluded from analysis. Diffusion restrictions were identified by two independent raters blinded for the final clinical diagnosis in three separate reading steps: First, only axial DWI, secondly only sagittal DWI, and lastly both DWIs together. Presence and size of DWI-lesions were documented for each plane. Differences between the observers were settled in consensus in a separate joint reading.ResultsOf 73 included patients, 46 patients were clinically diagnosed with brainstem infarction. Inter-observer agreement was excellent for the detection of brainstem lesions in axial and sagittal DWI (kappa = 0.94 and 0.97). In 28/46 patients (60.9%) lesions were detected in the axial plane alone, whereas in 6 more patients (73.9%) lesions were detected in the review of both sequences together. All lesions undetectable in the axial plane were smaller than 5 mm in cranio-caudal direction.ConclusionsThin-sliced sagittal DWI in addition to axial DWI improves the detection rate of brainstem infarction with little additional expenditure of time.

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“…Vascular theory has been able to partly explain the specific involvement at this site, since SCC is supplied by the vertebrobasilar system, while other parts of the corpus callosum receive their circulation via the carotid system. However, absence of lesions in other areas supplied by the vertebrobasilar system is one shortcoming of the vascular theory 2,6,7 .…”

Section: Discussionmentioning

confidence: 99%

Clinical and Radiological Significance of Transient Brain Lesion in the Corpus Callosum Splenium: 2 Case Reports

Eren¹,

Öngün²,

Öztürk³

2018

Kafkas J Med Sci

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Although rare, splenium of the corpus callosum (SCC) may be involved in many etiological conditions. Most forms of involvement are permanent and minorities of these are transient. The pathophysiology is intra-myelinic axonal edema related to hyponatremia and local inflammatory cell infiltration. The first case; 34-years-old female patient accepted to our unit with recurrent complex-partial seizures. She had epilepsy for 10 years and carbamazepine using for 4 years. Second case; 22-years-old female patient presented with vomiting, nausea and visual deficiency. Both cases magnetic resonance imaging (MRI) showed focal diffusion limitation in SCC. A comprehensive diagnostic work-up was carried out to account for these clinical and neuro-radiological presentations. 1-month follow up MRI showed resolution of these lesions. Previously, transient limitation of diffusion of SCC has been mostly reported in epileptic patients and treatment with anti-epileptic agents. However, many other conditions may result the appearance of similar clinical states. These patients may have mild form of encephalopathy and the prognosis is generally good. MRI is particularly sensitive in early identification of these lesions. A good understanding of the transient nature of the condition may allow avoidance from unnecessary invasive diagnostic and therapeutic methods.

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Etiology of Corpus Callosum Lesions with Restricted Diffusion

Cited by 19 publications

References 19 publications

Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava–Bignami Disease: A Case Report and Literature Review

Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava–Bignami Disease: A Case Report and Literature Review

Improved detectability of acute and subacute brainstem infarctions by combining standard axial and thin-sliced sagittal DWI

Clinical and Radiological Significance of Transient Brain Lesion in the Corpus Callosum Splenium: 2 Case Reports

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