Etiology of Down Syndrome: Risk of Advanced Maternal Age and Altered Meiotic Recombination for Chromosome 21 Nondisjunction

Dey, Subrata Kumar; Ghosh, Sujoy

doi:10.5772/18333

Cited by 2 publications

(3 citation statements)

References 66 publications

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“…This observation was very consistent with the previous observation, who reported 45% achiasmate meiosis associated with MI NDJ of Chromosome in US population. With similar approach for Indian Down Syndrome population (Kumar and Ghosh, 2011), there was a score of 30.8cm map length of maternal MI non-disjoined Chromosomes, which further confirmed the fact that reduced recombination due to absence of chiasma or less recombination frequency in some way increases the risk of NDJ.…”

Section: Maternal Agementioning

confidence: 57%

“…Absence of chiasma formation left the homologous pair free to drift randomly to the poles and if they move together to same pole aneuploidy results. As far as chromosome NDJ is concerned, achiasmate meiosis is the major cause of reduction in recombination frequency (Kumar and Ghosh, 2011), although fall in double exchange frequency was reported too. In the analysis of etiology of DS birth in Indian cohort, there was a record recorded only ~22% detectable crossover on MI non-disjoined chromosome in maternal meiosis (Kumar and Ghosh, 2011).…”

Section: Maternal Agementioning

confidence: 99%

“…As far as chromosome NDJ is concerned, achiasmate meiosis is the major cause of reduction in recombination frequency (Kumar and Ghosh, 2011), although fall in double exchange frequency was reported too. In the analysis of etiology of DS birth in Indian cohort, there was a record recorded only ~22% detectable crossover on MI non-disjoined chromosome in maternal meiosis (Kumar and Ghosh, 2011). This observation was very consistent with the previous observation, who reported 45% achiasmate meiosis associated with MI NDJ of Chromosome in US population.…”

Section: Maternal Agementioning

confidence: 99%

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Dietary Habits and Impact of Good Nutrition in Children With Down Symdrome in Rivers State, Nigeria

BAMSON, Minaseichinbo,

MANDAH, Stella Otito

2024

njhe

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The study assessed the dietary habit and impact of good nutrition on children with down syndrome in Obio Akpor Local Government Area in Rivers State. The study was guided by two research questions and two hypotheses. A descriptive survey design was adopted. All mothers with down syndrome children in Obio Akpor Local Government Area of Rivers State formed the population. Purposive sampling was used to select the sample size of 370 for the study. The instruments used for data collection were questionnaire, interview and focus group discussion. The instrument was face validated and the reliability determined using Cronbach Alpha,a reliability coefficient 0.68 was obtained. Data was collected using structured questionnaire and analyzed using the descriptive analysis (mean and standard deviation). The findings of the study showed that, mothers know the importance of good nutrition to the health of their children. The study also revealed that mothers are aware of nutrition can help enhance the health of the children, but they do not know the essential nutrient that are necessary for children with down syndrome. Based on the findings of the study the following recommendations were made; foods and nutrition counsellors should be recruited in various local government areas to enlighten the mothers of down syndrome children on the importance of nutrition, and how it improves proper functioning of development of the child. Government should sponsor awareness programmes that will assist the parents of the down syndrome children on how to go about the dietary habit of their children.

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Section: Maternal Agementioning

confidence: 57%

Section: Maternal Agementioning

confidence: 99%